Training at MSKCC I heard from Jerry Posner, Josep Dalmau, Bob Darnell etc... about autoimmune paraneoplastic syndromes. They observed that the cancers tended to be kept in check. This led to the hope that we could treat cancer with immunotherapy. This promise is now starting to be realized.
After two years I finally got an appointment with a Family Physician. An AI would have done a better job. At the risk of generalizing, Quebec Health care may well be the worst in the developed world.
The Rush hour (Rush hour of glucose utilization early in the light phase when glucose if funneled into multiple biosynthetic pathways). Human (left) and fly (right), either side of a schematic showing 13C-Glucose feeding into glycolysis, pentose phosphate pathwat or TCA cycle, over a watercolour wash. Image credit Pinky Kain.
How do #circadian clocks regulate glucose processing? By integrating human metabolite profiling with isotope-tracing in #Drosophila, this study defines daily rhythms in #glucose utilization that are influenced by circadian timing @plosbiology.org 🧪 plos.io/3Olm1M1
Diffusion MRI (dMRI) is a powerful tool to study white matter maturation. In our new preprint, we process and distribute a new resource of >24,000 ABCD dMRI scans using open source tools! We then evaluate how methods shape inferences about development.
🔗 www.biorxiv.org/content/10.6...
Comparative anatomy of brain metabolism in human and macaque (and other species). The dichotomy between glucose as fuel and glucose for tissue building is conserved across species. @moohebatpe.bsky.social and @misicbata.bsky.social
www.biorxiv.org/content/10.6...
And every presentation
Wow! CIHR expects me to input every publication resulting from my foundation grant... by hand!
Correlating brain maps across datasets is everywhere in neuroimaging. Here we ask: when you contextualize a brain map against genes, metabolism, or connectivity... What can you really conclude? How can we do better? We explore these questions here: tinyurl.com/2dudkevc
Kraepelin was right all along. We may need to think of schizophrenia along a neurodevelopmental - neurodegenerative axis.
"This study accords with previous work suggesting that dementia is a common outcome of schizophrenia and may arise from the illness itself."
I didn't think I would hear Fred Andermann mentioned in an old episode of Car Talk! The show opened with a story about uncontrollable laughter (aka gelastic seizures) as a symptom of hypothalamic tumour, which Ray suggested might explain Tom's behaviour. Then cited Dr Andermann.
Beautifully outlined, how reviewer comments and curiosity should usually be suggestions not commandments.
New paper in Imaging Neuroscience by Sebastian Dresbach, Renzo Huber, et al:
Laminar CBV and BOLD response characteristics over time and space in the human primary somatosensory cortex at 7T
doi.org/10.1162/IMAG...
It’s really quite shocking Wellcome didn’t have internal policy/feedback systems that prevent burning considerable resources on pseudo-science…
New paper in Imaging Neuroscience by Maria Hakonen, Jyrki Ahveninen, et al:
Function of the auditory cortex characterized by its intrinsic dynamic coactivation patterns estimated in individuals
doi.org/10.1162/IMAG...
New paper in Imaging Neuroscience by Nikhil V. Lakhani, Joseph W. Kable, et al:
A meta-analysis of neural systems underlying delay discounting: Implications for transdiagnostic research
doi.org/10.1162/IMAG...
New paper in Imaging Neuroscience by Timothy Lawn and Mitul A. Mehta:
Towards molecular selectivity in pharmacoimaging: Comment on van den Bosch and Cools
doi.org/10.1162/IMAG...
Organization of neuropeptide systems in the human brain | doi.org/10.1038/s415...
Neuropeptides are functionally diverse signaling molecules in the brain and body.
@cebric.bsky.social curates an atlas of neuropeptide receptors and relates it to brain function @natneuro.nature.com 🧩 🧠 ⤵️
Hyperface: a naturalistic fMRI dataset for investigating human face processing www.biorxiv.org/content/10.64898/2026.03...
Spatial organization of AQP4 channels in the human brain: links with perfusion, edema, and disease vulnerability | doi.org/10.64898/202...
Aquaporins are a key component of the brain’s glymphatic system. How are they distributed and how do they relate to healthy brain function and dysfunction? ⤵️
Synaptome architecture shapes regional dynamics in the mouse brain | doi.org/10.1371/jour...
How do diverse synapses relate to the spatial patterning of whole-brain dynamics? Justine Hansen explores @plosbiology.org ⤵️
Any donut shops nearby?
Here we gooo!
Will fMRI become obsolete for measuring striatal reward signals?
Probably not anytime soon…
Still, in our latest paper, we use AI to take a step toward decoding striatal reward signals from EEG — maybe nudging the fMRI monopoly just a little :)
direct.mit.edu/imag/article...
Group picture including Steven "Epstein? I barely knew him" Pinker. www.thenerve.news/p/epstein-bi...
New @nature.com
The brains of Super Agers produce more neurons than people some 50 years younger, a neurogenesis resilient signature linked to exceptional cognitive health and memory skills
nature.com/articles/s41...
"The only thing worse than being talked about is not being talked about.”
