An illustration of an apical region of an animal cell in cross section, shown crowded with individual molecules. The plasma membrane is densely occupied by influenza virus glycoproteins, and from the surface bud influenza virions with different morphologies (L-R): spherical, bacilliform, filamentous with a genome, filamentous and empty, filamentous with a helical inner layer, and filamentous with a cofilactin cytoskeleton.

🚨New pre-print!🚨
Because influenza virions are highly variable in form no single method can show their molecular architecture in detail. Here, we integrate multiple structural and compositional approaches to identify new features of these beautiful virus particles
www.biorxiv.org/content/10.6...

Q1020R in the spike proteins of MERS-CoV from Arabian camels confers resistance against soluble human DPP4 | Journal of Virology Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging virus that can cause severe lung disease, MERS, and is transmitted from camels to humans. Although MERS-CoV infects camels in both Africa and Arabia, MERS cases have only been documented in Arabia for reasons that remain incompletely understood. Here, we provide evidence that viruses recently circulating in Arabian camels and causing human infections are less susceptible to inhibition by human soluble DPP4 (sDPP4)—a secreted version of the viral receptor that is present in various bodily fluids. Furthermore, we link sDPP4 resistance to mutation Q1020R in the spike protein of these viruses. These results suggest that viruses currently circulating in Arabian camels are better equipped to overcome a natural barrier to infection, sDPP4, than those circulating in African camels.

Q1020R in the spike proteins of MERS-CoV from Arabian camels confers resistance against soluble human DPP4 | Journal of Virology journals.asm.org/doi/10.1128/...

I am so excited to share our new findings with you! We provide the structural evidence for a direct protein-to-DNA information pathway, showing how a bacterial enzyme 'reads' its own structure to 'write' DNA. www.science.org/doi/10.1126/...

A 3D model of DNA. Text says RSB training, an introduction to CryoEM, Tuesday 7 July, 9:30-16:30, The University of Leicester

Are you looking for a training course that will provide you with an introduction to cryoEM and its applications in structural biology ? Then join us in July!

📆 Tues 7 Jul, 9:30-16:30, University of Leicester

Book your place: my.rsb.org.uk/item.php?eve...

#Training #CryoEM

Congrats! 🎉

🚨 New paper alert 🧬
Our work from the @michellepeckham.bsky.social lab is now out in #ScienceAdvances.

We present the #cryoEM structure of shutdown human non-muscle myosin 2A, showing how ionic interactions stabilise auto-inhibition and how mutations disrupt this state.

👉 tinyurl.com/4de8teyh

56 toewijzingen in de Open Competitie ENW-XS pakket 26-1 | NWO De onderwerpen variëren van het ontrafelen van ziektemechanismen in het brein en het ontwikkelen van nieuwe, niet invasieve methoden om kankers eerder op te sporen tot het verbeteren van technologie v...

Exciting news from our lab 🎉

One of our talented postdocs, Dr. Robin Veenstra, has been awarded an NWO XS grant for the high-risk, high-reward project “Bridging the gap between virus and host.”

www.nwo.nl/nieuws/56-to...

Congrats Robin, and good luck with the project!

Thermo Fisher Scientific Cryo-EM SPA introductory mini-course (14 April, 21 April & 5 May) Learn the fundamentals of cryo-EM Single Particle Analysis (SPA) in this Cryo-EM Essentials introductory mini-course.

Part 1 was just the beginning 🚀

After the Cryo-EM SPA mini-course kickoff with @royalmicrosoc.bsky.social & ThermoFisher Scientific, don’t miss:

🗓️ Apr 21: Data Collection
🗓️ May 5: Data Processing (with Structura Biotechnology)

Register 👉 bit.ly/4cdEnrr

#cryoEM #CryoSPARC

This week, we had our biannual away day, a valuable opportunity to step away from the bench and connect as a team.

We heard career talks from our principal investigators, as well as guest speakers who shared perspectives on career paths beyond academia.

A big thanks to the organising committee!

Good luck! 🤞🏻

Postdoctoral Research Assistant in Structural Biology at University of Oxford Looking for a new job opportunity in academia? Check out this job opening for a Postdoctoral Research Assistant in Structural Biology on jobs.ac.uk!

Postdoc position open at the Dunn School, University of Oxford #cryoEM #teamtomo #cilia #postdoc, come join us! Deadline 15th May.

www.jobs.ac.uk/job/DRC546/p...

One more Asgard archaeon! Meet Nerearchaeum marumarumayae from the microbial mats of Shark Bay, Australia. It interacts with #bacteria via intercellular nanotubes 🧬!
#microbiology #archaea #eukaryotes #MicroSky #ArchaeaSky
@currentbiology.bsky.social
www.cell.com/current-biol...

1/ Excited to share our preprint! 🥳

Degradation of aromatic compounds, including BTEX pollutants, requires highly endergonic aromatic ring reduction. Using #cryoEM and in situ #cryoET, we show how BCRII couples electron bifurcation modules in one giant redox machine

www.biorxiv.org/content/10.6...

Ja hoor, totaal niet moeilijk 😅

Thanks! You will also be a pro at Dutch soon after spending so much time with Tino 😉

Ik ben geslaagd! 🎉

📣Please check out our latest preprint on the #structure, stability and specificity of the type II secretion pilus. #nmr #cryoEM
Great collab with the teams of @oliverafr.bsky.social Nilges @pasteur.fr @ipdbsc.bsky.social @cnrsbiologie.bsky.social
Egelman, Shevchik
www.biorxiv.org/content/10.6...

Decoding epitope immunodominance in HIV Env using cryoEM and machine learning pubmed.ncbi.nlm.nih.gov/41959402/ #cryoEM

Microtubules in the axon are GDP bound but adopt a stable GTP-like expanded state pubmed.ncbi.nlm.nih.gov/41951886/ #cryoEM

Structure and assembly of Borna disease virus 1 nucleoprotein-RNA complexes pubmed.ncbi.nlm.nih.gov/41961918/ #cryoEM

Hepatitis E virus replication is maintained in proliferative cells within the intestinal crypt www.science.org/doi/10.1126/...

Shapeshifting spike proteins help coronaviruses infect whales and dolphins Coronaviruses use spike proteins to enter cells. This study shows these spikes can change shape, helping the viruses adapt to new hosts, including whales and dolphins. Understanding this flexibility may help predict and prevent future cross-species infections.

For a plain-language overview of our work, see this lay summary courtesy of Kudos:

www.growkudos.com/publications...

Species- and variant-specific ACE2 compatibility shapes SARS-CoV-2 spillover potential in North American cervids pubmed.ncbi.nlm.nih.gov/41957014/ #cryoEM

Human monoclonal antibodies that target the SFTSV glycoprotein Gn head from four neutralizing epitope groups pubmed.ncbi.nlm.nih.gov/41955097/ #cryoEM

Evaluating the Volta phase plate for improved tomogram alignment in cryo-electron tomography pubmed.ncbi.nlm.nih.gov/41954506/ #cryoEM

Nice work! Just curious - what did the processing look like for this? Did you try homogeneous ab-initio refinement?

Dimerisation and twist reversal of the Lewy fold in alpha-synuclein mutants with Parkinson's disease and dementia.

Together with Yang Yang (now at @vai.org) and Michel Goedert. 🥳

www.biorxiv.org/content/10.6...

Scientific Database Curator Your role We are looking to recruit an expert structural biologist with an experimental background to join the EMDB as a biocurator within the EMBL-EBI OneDep data curation team. High-quality…

🚨Job opening 🚨: In 2020, cumulatively 10,000 #cryoEM structures had been resolved. By 2025, 10,000 #cryoEM structures were determined within a single year. Join the international effort making all this data available. OneDep biocurator on the EMDB team: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Cetacean coronavirus spikes highlight S glycoprotein structural plasticity pubmed.ncbi.nlm.nih.gov/41950284/ #cryoEM

Out now at PLoS Pathogens @plos.org. Nice collaboration with @danielhurdiss.bsky.social @utrechtvirology.bsky.social. Some beautiful glycoproteomics work by @tshamorkina.bsky.social mapping N- and O-glycan shield of coronaviruses infecting whales and dolphins 🐋🐬🐳.
journals.plos.org/plospathogen...