Death of the sampling theorem? tl;dr: A team from Columbia University led by Ken Shepard and Rafa Yuste claims to beat the 100 year old Sampling Theorem [1,2]. Apparently anti-aliasing filters are superfluous now because one can…

There was this Tsai/Yuste/Shepard paper that meister famously eviscerated. markusmeister.com/2018/03/20/d... It seems that the authors never retracted the paper (or does ieee not mark retractions)? If not, does anyone know why not? @retractionwatch.com

Me: confident in surgery. Mouse brain, three weeks later: ‘Sure, bud’. 😊🧠🥲

Mouse stereotactic surgery never gets old: you level a tiny irregular skull, go by coordinates based on eyeballed reference points, deliver microdrops of virus following protocolised superstition and whoom, three weeks later, the exact subregion you aimed for lights up (well, sometimes) ✨🧠🧪

✋ would love to join! 😊

What does the mean mean? A simple test for neuroscience Author summary Neuronal activity is highly dynamic—our brain never responds to the same situation in exactly the same way. How do we extract information from such dynamic signals? The classical answer...

This shows that we need to apply averages carefully because they mean different things in different experimental contexts. In other words - THINK BEFORE YOUR AVERAGE! And feel welcome to use our test to help you do that. ;)
journals.plos.org/ploscompbiol...

A bursty bursty cartwheel neuron firing like crazy in response to a depolarizing current injection.

I usually focus on neurons that fire crazy fast, but I like neurons that burst, too!!

10 week old sliced immunohistological stain of a dorsal forebrain organoid. Stained for HTR2A in red, HTR2C in green (interior green looks non-specific), BCL11B in magenta, and DAPI in blue.

Happy #FluorescentFriday

Here is a cerebral organoid expressing 5-HT2A receptors (red) along its outer surface. They seem to be a different set of cells than the CTIP2 positive deep layer neurons (magenta). There seems to be some believable 5-HT2C (green) signal basal to the rosettes too 🔬 #sciart

Electrophysiology electrode surrounded by pyramidal neurons. The neuron waveforms are shown on top of each neuron, nearby neurons have larger waveforms and faraway neurons have very tiny waveforms. Pyramidal neurons were modified from scidraw.io, Claudi, F. (2020). pyramidal neuron. Zenodo. https://doi.org/10.5281/zenodo.3925905)

Felt a little extra today when preparing a spike sorting lecture and put together these illustrations, I could not find anything similar for single electrodes! 🧪🧠⚡

#neuroskyence #SciArt

If you are interested in neural manifolds, dimensionality, brain states, and/or top-down modulation you are gonna like this one! 🧠🙈💫🧪

"Neural manifolds in V1 change with top-down signals from V4 targeting the foveal region" doi.org/10.1016/j.ce...

Also enjoy this animation :) #SciArt #neuroskyence

ONIX: a unified open-source platform for multimodal neural recording and perturbation during naturalistic behavior - Nature Methods ONIX is a data acquisition system for recording freely behaving mice. It can accommodate a variety of recording technologies, while maintaining minimal impact on animal behavior.

A paper about our next generation data acquisition system, ONIX, was just published: www.nature.com/articles/s41...