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Posts by Anders Nelson

Home | Levine Lab

📣 Exciting news: my lab is moving to the Krembil Institute at the University of Toronto’s University Health Network in Fall 2026.

We’ll be recruiting for all roles, so reach out if you’re interesting in joining us to study spinal circuits for sensorimotor control

www.levine-lab.org

1 day ago 131 32 17 4
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Acetylcholine demixes heterogeneous dopamine signals for learning and moving Nature Neuroscience - Jang et al. measured dopamine and acetylcholine release in the striatum of rats performing a decision-making task and found that the relative timing of cholinergic and...

Thrilled to share our new paper, which shows that the relative timing of cholinergic and dopamine release dynamically gates whether dopamine acts as an RPE for in vivo plasticity and reinforcement learning. www.nature.com/articles/s41...

4 weeks ago 155 68 2 3

NYU's Center for Neural Science is seeking a faculty candidate that would be jointly appointed with our Tandon School of Engineering. We are looking for post-doc applicants with neuroengineering or computational backgrounds.

apply.interfolio.com/182074

1 month ago 33 29 1 0
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Potentiation of active locomotor state by spinal-projecting serotonergic neurons Fenstermacher et al. map the structure and activity of spinal-projecting serotonergic neurons and show that 5-HT populations are engaged in a context-dependent manner during locomotion. Activation of ...

www.cell.com/neuron/fullt...

2 months ago 6 4 0 0
A synaptic locus of song learning Learning by imitation is the foundation for verbal and musical expression, but its underlying neural basis remains obscure. A juvenile male zebra finch imitates the multisyllabic song of an adult tutor in a process that depends on a song-specialized cortico-basal ganglia circuit, affording a powerful system to identify the synaptic substrates of imitative motor learning. Plasticity at a particular set of cortico-basal ganglia synapses is hypothesized to drive rapid learning-related changes in song before these changes are subsequently consolidated in downstream circuits. Nevertheless, this hypothesis is untested and the synaptic locus where learning initially occurs is unknown. By combining a computational framework to quantify song learning with synapse-specific optogenetic and chemogenetic manipulations within and directly downstream of the cortico-basal ganglia circuit, we identified the specific cortico-basal ganglia synapses that drive the acquisition and expression of rapid vocal changes during juvenile song learning and characterized the hours-long timescale over which these changes consolidate. Furthermore, transiently augmenting postsynaptic activity in the basal ganglia briefly accelerates learning rates and persistently alters song, demonstrating a direct link between basal ganglia activity and rapid learning. These results localize the specific cortico-basal ganglia synapses that enable a juvenile songbird to learn to sing and reveal the circuit logic and behavioral timescales of this imitative learning paradigm. ### Competing Interest Statement The authors have declared no competing interest. National Institutes of Health, K99 NS144525 (DCS), F32 MH132152 (DCS), F31 HD098772 (SB), R01 NS099288 (RM), RF1 NS118424 (RM and JP)

Where does learning through imitation happen in the brain?

In juvenile zebra finches, we pinpoint a synaptic locus of song learning in a cortico-basal ganglia circuit and leverage this localization to measure the timescale of consolidation and make birds learn faster! #neuroskyence (1/14)

3 months ago 75 28 5 8
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Ontogeny of the spinal cord dorsal horn The dorsal horn of the mammalian spinal cord is organized into laminae where each layer is populated by different neuron types, has distinctive circuit connections, and plays specialized roles in beha...

Excited to share @rbrianroome.bsky.social ‘s beautiful paper on development of the dorsal horn of the mouse spinal cord @science.org

This is how the anatomical organization and cell types that process pain, touch, body position and more are laid down.

www.science.org/doi/10.1126/...

3 months ago 132 41 10 2

Congratulations, Ariel! It looks great.

3 months ago 1 0 1 0
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Now out in @nature.com: Our study discovering a neural circuit in Drosophila that predictively inhibits proprioceptor axons during voluntary leg movements, such as walking and grooming. www.nature.com/articles/s41...

7 months ago 72 30 4 2
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Complementary cortical and thalamic contributions to cell-type-specific striatal activity dynamics during movement Coordinated motor behavior emerges from information flow across brain regions. How long-range inputs drive cell-type-specific activity within motor circuits remains unclear. The dorsolateral striatum ...

pretty cool

www.biorxiv.org/content/10.1...

9 months ago 2 1 0 0

We are hiring a new research assistant! Official job post to follow. Please reach out or visit markrossilab.org if you are interested.

10 months ago 3 3 0 1

😱

11 months ago 0 0 0 0
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Postdoctoral Associate: Corticospinal Circuits for Skilled Movement - New York City, New York job with Nelson Lab at New York University | 38767 Join the Nelson Lab at NYU to study how corticospinal circuits enable skilled behavior.

Please share!

neurojobs.sfn.org/job/38767/po...

1 year ago 8 5 0 1
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📣📣📣 This is a call for PhD students in neuroscience!

✅ Are you a senior PhD student in neuroscience? 🧠
✅ Looking for career development opportunities?💼
✅ Want to visit NYC in spring?🗽
✅ Considering a postdoc at NYU? 🥼
✅Apply for CoNNExINS!
wp.nyu.edu/connexins/

Deadline extended to April 11th!

1 year ago 4 7 0 1

And science continues… check out our new work led by @rbrianroome.bsky.social

1 year ago 18 6 4 0
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Differential modification of ascending spinal outputs in acute and chronic pain states Yarmolinsky et al. characterize the sensory tuning of mouse spinal projection neurons under normal conditions and in acute and chronic pain hypersensitivity. Using longitudinal in vivo calcium imaging...

www.cell.com/neuron/fullt...

1 year ago 3 0 0 0

Same here. I've been pushing hard the past 6 months on my resubmission! Now what?

1 year ago 1 0 0 0
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A brain-wide map of descending inputs onto spinal V1 interneurons Chapman et al. generate a brain-wide atlas of supraspinal inputs to cervical V1 interneurons. Monosynaptic input arises from over two dozen brain regions, some of which preferentially innervate molecu...

www.cell.com/neuron/fullt...

1 year ago 2 0 0 0
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Cell-type-specific auditory responses in the striatum are shaped by feedforward inhibition How neurons in the posterior striatum encode auditory information is not well understood. Druart et al. report that direct pathway neurons in the striatum respond more strongly to auditory stimuli. Th...

www.cell.com/cell-reports...

1 year ago 1 2 0 0
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Pharmacological blocking of spinal GABAA receptors in monkeys reduces sensory transmission to the spinal cord, thalamus, and cortex Mahrous et al. examine the controversial role of GABAARs in sensory transmission in the monkey cervical spinal cord. They find that blocking spinal GABAARs reduces sensory input to both motoneurons an...

More compelling evidence that axoaxonal GABA release in the spinal cord can increase sensory transmission. Cell Reports www.cell.com/cell-reports...

1 year ago 5 1 1 0
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📣📣📣

✅ Are you a senior PhD student in neuroscience? 🧠
✅ Looking for career development opportunities?💼
✅ Want to visit NYC in spring?🗽
✅ Considering a postdoc at NYU? 🥼
✅Apply for CoNNExINS!
wp.nyu.edu/connexins/

Please RT!

1 year ago 13 13 0 0
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Submit a Sidewalk Shed for the Sheddies The sidewalks of our city should be safe, clean, and welcoming. Unfortunately, scaffolding and sidewalk sheds have made our sidewalks places New Yorkers now steer clear of. Not only are sidewalk sheds...

Nice shot. Certainly not a contestant for the Sheddies: www.nysenate.gov/questionnair...

1 year ago 1 0 0 0
CoNNExINS CoNNExINS (Colloquium at NYU for Networking: Extramural for Invited Neuroscience Students)

We are now accepting applications for 2025 Connexins! This is an in person symposium for senior graduate students to share their works with the NYU neuroscience community. Please RT!!! wp.nyu.edu/connexins/

1 year ago 4 4 0 0

It's official, the Rich lab is now part of the Center for Neural Science at NYU! I'm thrilled to be joining CNS! At the same time, I'll miss my amazing colleagues at Sinai (even though we're not going far).

Here's to new adventures in the new year!🥂

1 year ago 81 8 8 0

This year WPI reformulated Kwik-Cast to have a lower concentration of pigment. This increases the shelf stability of the product but unfortunately makes it transparent. Are there alternative cold-curing and biocompatible products?

1 year ago 1 0 0 0
old school 🤝 new school

old school 🤝 new school

old school 🤝 new school

1 year ago 5 0 0 0
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