In conclusion, an obligatory reminder that the president's budget request is often rejected by Congress—but that it is an important document of White House _intent_ which matters more and more as parts of the federal research funding process leave the traditional legislative route.
Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
#paper:
Drying tissue samples enhances contrast in X-ray phase contrast imaging while largely preserving ultrastructure. 🧠🔬
doi.org/10.1107/S160...
@safekhan.bsky.social @andreas-t-schaefer.bsky.social
@crick.ac.uk @embl.org @imperialcollegeldn.bsky.social @esrf.fr @uclnpp.bsky.social
The form is short. You can submit anonymously. Even one sentence counts.
"I want NIH to fund the best science based on merit, not politics" is a valid comment.
Deadline: May 16, 2026
grants.nih.gov/grants/guide...
but see: bsky.app/profile/dang...
Writing out a conversation I’ve been having a lot at this conference:
Things in US science are far, far worse than people know.
Far worse than even other scientists know.
1/
Check out the newest work from our, from Fabricio Nicola @fabricionicola.bsky.social on mouse jumping and spinal cell types.
Excellent collab with @vulcnethologist.bsky.social
www.biorxiv.org/content/10.6...
Friday, 13:15 (Poster 2-048) at @cosynemeeting.bsky.social #cosyne2026: @allierced.bsky.social and @lappalainenjk.bsky.social present how they made GNNs learn interpretable circuit models from neural activity. Code: saalfeldlab.github.io/flyvis-gnn/
this was a good interview
sounds like the incanted preamble to a powerful curse!💀(But I agree with your sentiment completely. What a complete horror.)
ping
A central somatotopic map of the fly leg supports spatially targeted grooming www.biorxiv.org/content/10.64898/2026.02...
Join us in building foundational datasets and models for microscopy with @jakobtroidl.bsky.social and many others
AI Engineer Pre-Training: lnkd.in/eyEEV5nm
AI Engineer Post-Training: lnkd.in/eShVQ3y9
Data Engineer Data: lnkd.in/eCvm58xH
Data Engineer Pipelines: lnkd.in/ec6qGJkX
ai.hhmi.org
look how cool that imaging rig is they’re using
Excited to share our new preprint exploring how Paramecium achieves diverse flow functions, i.e. feeding and swimming, simultaneously. This work was spearheaded by our ExM expert, PhD student Daphne Laan @daphnelaan.bsky.social :
www.biorxiv.org/content/10.6...
Great to see our paper on light-intensity dependent swimming patterns in #Chlamydomonas out now in Phys Rev Lett. as an Editors' suggestion! With a nice commentary by @philipcball.bsky.social.
Chlamy actively modulate the beat planes of their #cilia!
journals.aps.org/prl/abstract... #protistsonsky
From @bdpedigo.bsky.social: a super efficient, highly reliable, and very generalizable method for mesh structure classification, applied here to spine detection across basically every synapse onto a cell in the MICRoNS dataset.
If your imaging system has poorly characterized constant distortions leading to chromatic aberration, shoddy stitching, or false measurements (the answer is likely yes), you may want to give this tool a try. Native installers for Linux, Mac, Win under Releases github.com/saalfeldlab/...
As money woes hit the University of Chicago, the oldest private marine laboratory in the United States is striking out on its own. https://scim.ag/4trAN3l
Please spread the word:
We invite applications to a two-week Computational Biology workshop in Singapore, June 14-27.
This NSF-funded workshop brings together 16-20 US grad students with international peers.
Apply by March 21: compbioasia.net
🧵 Details below:
A line plot with the numbers of NSF awards for fiscal years 2021-2026. The curve for fiscal year 2026 is quite a bit lower than those for 2021-2025 while the curve for fiscal year 2026 (in red) is much lower than all through the same date.
But, as they say, there is no time like the present
[OK, maybe the 1930s if you want to nitpick]
But, with some data wrangling, my first NSF Funding Curves!
2/3
beautiful protist ExM images here from @dudinlab.bsky.social and @gautamdey.bsky.social
Want to come do a postdoc with us?
We’re interested in how sensorimotor function is carried out by the cells and circuits of the spinal cord. We have an awesome team, lots of cool techniques, and we’re open to new ideas/approaches/connections. Get in touch!
I usually hesitate to post obituaries but this one, of my literary agent, Georges Borchardt, born in 1928, is so unusual that it deserves to be widely shared.
An incredible 20th century life
www.nytimes.com/2026/01/20/o...
CytoTape in a neuron
Our CytoTape work is published today in Nature @nature.com! CytoTape is a genetically encoded, flexible, intracellular protein tape recorder for spatiotemporally scalable and multiplexed recording of cellular activities continuously across weeks in vitro and in vivo. www.nature.com/articles/s41...
I had no idea Leiber had become so obscure!
Scatter plot with eye sight acuity (measured in cycles per degree) on the y-axis and eye diameter (in mm) on the x-axis. Birds tend to have higher acuity than mammals at a given eyesight, except anthropoid primates (monkeys and apes) that outperform most birds, except for a few raptors. Some birds of prey (falcons, eagles) exhibit the highest recorded acuity. Corvids cluster between other birds and anthropoids, showing higher acuity than would be expected.
Another bit on eye-sight: I've put together a plot on visual acuity in birds and mammals. Interestingly, corvids seem to have acuity that is a lot better than expected for their eye size/passerines in general. Is anyone aware of structural peculiarities of corvid eyes that might explain that? 🧪🪶
The bill includes a 33 percent budget increase for the NIH’s BRAIN Initiative, which has faced significant funding cuts over the past two years.
By @avaskham.bsky.social
#neuroskyence
www.thetransmitter.org/funding/neur...
The winner of the 2026 Pradel Research Award is H. Sebastian Seung of @princetonneuro.bsky.social! He is being honored for for transformative advances in computational neuroscience. Learn more about his discoveries: www.nasonline.org/award/pradel... #NASaward #neuroscience
What's the relation between voltage and calcium in dendrites? Xiang Wu studied this in CA2 hippocampal pyramidal cells in behaving mice. www.biorxiv.org/content/10.6...
