We're preparing an exciting series of master classes for 2026, come along, learn something new and chat with fellow early career bioinformaticians!

On Friday, @chloeterwagne.bsky.social will present:

“A scalable framework to link rare human variants to disease phenotypes using pooled prime editing”

Friday Oct 17th at 1:40pm, Rm205ABC

You can also catch up with Chloé at her poster, 5002T, Thursday 2:30-4:30

Hello Boston! The lab is delighted to be at #ASHG25🧬
Check out our talks over the next few days - all unpublished stories.

Kicking things off is @michaelherger.bsky.social presenting "Saturation mutagenesis of 37 human splicing factor genes with pooled prime editing". Today @2pm, Rm205abc

Also 👇

This was a great collaboration with @joachimdejonghe.bsky.social and @chloeterwagne.bsky.social

Excited to be presenting our work on "Saturation mutagenesis of 37 human splicing factor genes using pooled prime editing" later today at #ASHG2025 during the Platform Session "RNA Functions Beyond Coding Sequences" (1:30-2:30PM, Room 205ABC).

Flying out from SF to Boston for #ASHG25! ✈️
I’ll be sharing how we combine computational tools and pooled prime editing to test thousands of rare variants and pinpoint those that impact disease.
📅 Session 81 Friday | 🪧 Poster #5002T

Future Leaders in Biomedical Sciences: How to Apply How to apply for a Future Leaders in Biomedical Sciences Scholarship. Open to candidates of Black or mixed Black heritage only.

This year the lab is also participating in the Crick's Future Leaders in Biomedical Sciences scholarship programme, which has opened for candidates of Black or mixed Black heritage.

www.crick.ac.uk/careers-and-...

Can’t believe it’s been 3 years since I started my PhD in the Genome Function Lab at The Crick! It’s been an amazing journey in a really ambitious and supportive lab, with a fantastic Supervisor.

Feel free to reach out if you’d like to hear more about my experience in the group!

Heading into my 4th year in this lab, it continues to be an inspiring and rewarding place to grow every day. Can’t recommend the team, PI, and science enough 🧬✨

Thanks to everyone for joining and sharing science & advice. This year was, once again, a lot of fun! 🎉
Big kudos to my co-organisers for making it all possible 🌟

👉 Come and join our amazing community: londonomics.co.uk

Massive congrats to my fantastic PI, @gregfindlay.bsky.social! 🎉 Our lab is on its way to explore the non-coding region - exciting times ahead! 🚀

Read more about it👇

Thrilled to have been selected as a speaker at #ASHG2025 🧬 Annual Meeting in Boston.
If you are interested in the development of high-throughput assays to test non-coding variant effects come join us at Session 53 on Thursday, October 16th!

Four people sitting on chairs on a stage as part of a panel, each with a microphone in front of them, with Brian Cox in the middle. A group of audience members can be seen from behind watching the stage.

What is the future of fertility?

Meet the panellists for one of the upcoming live episode recordings of our podcast, A Question of Science:
@profjoyceharper.bsky.social, @lucyvandewiel.bsky.social,
@nmoris.bsky.social and @gunes-taylor.bsky.social.

🎟️ Book now ⬇️
🔗 lostintv.com/tv-show?id=1...

Congratulations to Anjali and the team on this fantastic work!! I was fortunate to contribute in the very early stages during my internship in @davidaknowles.bsky.social lab. Wonderful to see how far it’s come.

We recently performed SGE of RNU4-2 and identified functionally impactful variants underlying a new recessive disease. Today, the team led by @rociorius.bsky.social @alexblakes.bsky.social @cassimons.bsky.social & @nickywhiffin.bsky.social provide in-depth analysis of its clinical presentation. 🧵⬇️

This story is the PhD work of Phoebe Dace, who has done remarkably well to bring this all together. Congrats, Phoebe! 👏
Thanks to the lab, Nicole, @lcubes.bsky.social @chloeterwagne.bsky.social and Megan), our great collaborators, and @crick.ac.uk & @cancerresearchuk.org for vital funding. 🙏 END/16

Thrilled to see Phoebe's fantastic work out today on @medrxivpreprint.bsky.social
Saturation genome editing of BRCA1 across cell types, packed with insights 👇

Coming up in September!
➡️Christina Kajba @ckajba.bsky.social & Michael Herger @michaelherger.bsky.social — pooled prime editing screens in haploid human cells
➡️Jon Acosta — multiplexed in vivo base editing screens
#GeneticVariants #PrimeEditing
ℹ️https://www.varianteffect.org/seminar-series/

Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox - Nature Communications The majority of human genes can produce multiple isoforms, but studying their functional relevance requires tools to target specific isoforms. Here, the authors develop a CRISPR-based exon-exon juncti...

Excited for this to be out officially! It was a great team effort and has a lot of useful tidbits for studying isoform function. www.nature.com/articles/s41...

London computational biologist, mark your calendars and sign up: Londonomics symposium is back this September! ✨

🧬 Join us: londonomics.co.uk/index.php/ev...

Abstract deadline: August 12
👩‍💻 Don’t miss your chance to present your work and connect with the community!

See you there!

Super grateful for the opportunity to share recent project progress last week at the @crick.ac.uk and Partner Universities PhD Student Symposium! A big thanks to all the PhD volunteers whose time, care, and effort made this event such a supportive and engaging space for students ✨

Perplexity as a Metric for Isoform Diversity in the Human Transcriptome Long-read sequencing (LRS) has revealed a far greater diversity of RNA isoforms than earlier technologies, increasing the critical need to determine which, and how many, isoforms per gene are biologic...

New work from the lab trying to wrap our heads around the massive complexity of the human transcriptome revealed by long-read RNA-seq! Fun collab with Gloria Sheynkman. www.biorxiv.org/content/10.1...

Determining variant effects with pooled prime editing Nature Reviews Genetics - In this Tools of the Trade article, Christina Kajba and Michael Herger describe their screening platform, based on pooled prime editing, for large-scale functional...

Check out @ckajba.bsky.social and Michael Herger's concise description of their recent work. Thanks to Nature Reviews Genetics for featuring this.

rdcu.be/eraxZ

Looking forward to speaking at the @genomicsengland.bsky.social Summit tomorrow!
I'll be sharing insights from my current project on the Discovery Stage at 2 pm.

Come say hi if you're around!

Big congratulations to our very own Christina Kajba for winning a presentation award at #ESHG25.

You can read all about her work here:
www.cell.com/cell-genomic...

Come join us today at @UCL for our second workshop! ⚡⚡ Followed by drinks and pizza 🍕

Welcome back from the break! Next up @juliadiumenge.bsky.social from @alloxbio.bsky.social Mapping allosteric sites at scale to develop better drugs

Chloe Terwagne at #VariantEffect25

Next we have at #VariantEffect25 we have @chloeterwagne.bsky.social from @crick.ac.uk and @gregfindlay.bsky.social lab, telling us about her scalable framework to link rare human variants to disease phenotypes using pooled prime editing @varianteffect.bsky.social

Wow. "NIH" canceled my co-mentored (with Dave Sulzer) PhD student's F31 funding. His work is on understanding the genetics and neuroscience of language learning disorders. F31 provides no indirect $ to Columbia, just pays his salary. Not that it should matter, but he's an American citizen. W.T.F.