Intralysosomal pathogens differentially influence the proteolytic potential of their niche | Infection and Immunity Evading lysosomal degradation is of critical importance to successful intracellular pathogens. The lysosome, classically considered the waste disposal and recycling center of the cell, is a hostile en...

Coxiella & Leishmania both reside within a lysosome-like compartment in human cells, but appear to modulate the protease cohort in different ways. I’m pleased to share our latest story here, out this week in I&I: journals.asm.org/doi/10.1128/...
@hayleyjnewton.bsky.social @lauraem-lab.bsky.social

Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein and peptide C termini Nature Chemistry - In living systems, ATP provides an energetic driving force for protein synthesis and modification. Now, an engineered enzymatic tool has been developed for high-yield, ATP-driven...

Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C

Nuclear Roles for Canonically Lysosomal Proteases While the cysteine proteases legumain and cathepsins have traditionally been known as “lysosomal” proteases, there is increasing evidence to suggest that they also contribute to a wide range of ext...

Congrats to Anna and Marc for the publication of their review article "Nuclear Roles for Canonically Lysosomal Proteases.' Check it here: www.tandfonline.com/doi/full/10.... #LEMLab

The 13th General Meeting of the International Proteolysis Society will be held in Búsios, Brazil Oct 26-30, 2025. Training workshops will be held at the Instituto Oswaldo Cruz Oct 23-23. Register now! Links below.

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Cutting the diagnosis journey for children born with rare genetic diseases Families can wait years for a diagnosis of a rare genetic disorder, but a new test can provide answers in days for a better understanding of the condition and potentially earlier treatment, finds new...

We're super proud to see our study showing utility of proteomics in ultra-rapid variant prioritisation for suspected mito and other rare diseases out in Genome Medicine (rdcu.be/endwE). Too many amazing collabs to thank, so here are the big ones @daniellahock.bsky.social @thorburnmito.bsky.social!

The phase IIb results from the multi center trail of our cathepsin probe (VGT-309/abenacianine) are out. The probe met its endpoints and resulted in significant clinical events in 45% of patients. Great work by Vergent Biosciences and Dr. Sunil Singhal (UPenn).

www.vergentbio.com/press-releas...

Travel: protease.org/travel-awards

Young Investigator: protease.org/young-invest...

Register for the meeting and workshop: ipsbrazil.com.br

Apply for IPS membership: protease.org/membership

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We have travel awards available for early career researchers, and we are seeking nominations for the Ulrich auf dem Keller Young Investigator award for researchers within 6 years of establishing their independent labs. Please apply before June 30 so you don't miss out!

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The 13th General Meeting of the International Proteolysis Society will be held in Búsios, Brazil Oct 26-30, 2025. Training workshops will be held at the Instituto Oswaldo Cruz Oct 23-23. Register now! Links below.

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Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success - Nature Communications The zoonotic pathogen Coxiella burnetiiestablishes a unique intracellular niche within a lysosome-derived vacuole. Here Bird et al. undertook proteomic, cell biology and microbiology approaches to cha...

We also show that Coxiella incites the extracellular secretion of lysosomal content in a T4SS independent manner.

A wonderfully enjoyable collaboration with @lauraem-lab.bsky.social & @hayleyjnewton.bsky.social labs (with significant mass spec guidance from @nickescott.bsky.social!)

Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success - Nature Communications The zoonotic pathogen Coxiella burnetiiestablishes a unique intracellular niche within a lysosome-derived vacuole. Here Bird et al. undertook proteomic, cell biology and microbiology approaches to cha...

Excited to share this story from my PhD, out today in Nature Communications! We show that Coxiella removes cathepsin B to reduce lysosomal hostility and promote bacterial success. This depends on a vacuole established by effector CvpB.

www.nature.com/articles/s41...

I'm excited to share the next issue of QuickCuts reporting news from the… | Laura Edgington-Mitchell I'm excited to share the next issue of QuickCuts reporting news from the International Proteolysis Society. Registration for the next general meeting in Brazil is now open, so don't miss out! ...

www.linkedin.com/posts/laura-...

Great visit to Melbourne Uni to give a talk and visit with my former PhD student Laura Edgington-Mitchell and her lab.

Table from page 25 of the proposed restructure of ARC grants. Back text on white background, with the table delineated by a dark blue header row and alternating light and very light blue rows.

The ARC Board has proposed a major shake-up of the National Competitive Grants Program ▶️ www.arc.gov.au/engage-us/co...

I've only skimmed so far, but they propose reducing 13 grant schemes to 6, with intent & scope in the table👇

Submissions are being accepted in response until 13 April. Get to it!