congrats🎉

Molecular and functional dissection using CaMPARI-seq reveals the neuronal organization for dissociating optic flow-dependent behaviors Nature Communications - In this study, the authors develop CaMPARI-seq to link neural activity with molecular profiles in larval zebrafish. They identify inhibitory pretectal neurons required for...

Happy to share our new paper published in Nature Communications!
www.nature.com/articles/s41...
We developed CaMPARI-seq to link neural activity with molecular profiles and revealed how the brain distinguishes optic flow to guide behavior. Congratulations to our postdoc Koji Matsuda!

The neural mechanisms supporting the rise and fall of maternal aggression - Nature In mice, female aggression is governed by an amygdala–to–medial hypothalamus circuit that is strengthened during pregnancy and is dynamically amplified by oxytocin during lactation.

What has changed in mama bear brain (well, actually mice) to make her risk her life to attack a potential threat and protect her young? Oxytocin is the key! Happy to share our new study led by two awesome postdocs: Takashi Yamaguchi and Rongzhen Yan.
www.nature.com/articles/s41...

Zebrafish reveal new insights into the biology of autism In a new study, Yale researchers identified drug candidates that reverse disrupted behaviors in zebrafish carrying mutations in autism risk genes.

In a new study, @yale.edu researchers led by @yaleschoolofmed.bsky.social's @ehoffmanlab.bsky.social, MD, PhD 🥼 identified a promising candidate to rescue disrupted brain activity in zebrafish carrying mutations in autism risk genes 🦓🐠

Acetylcholine demixes heterogeneous dopamine signals for learning and moving Nature Neuroscience - Jang et al. measured dopamine and acetylcholine release in the striatum of rats performing a decision-making task and found that the relative timing of cholinergic and...

Thrilled to share our new paper, which shows that the relative timing of cholinergic and dopamine release dynamically gates whether dopamine acts as an RPE for in vivo plasticity and reinforcement learning. www.nature.com/articles/s41...

a while ago, I made this feed for neuroscience/cognitive science summer schools. after some tuning, it generally manages to find cool events. 🙂

bsky.app/profile/did:...

Lifelong behavioral screen reveals an architecture of vertebrate aging Mapping behavior of individual vertebrate animals across lifespan could provide an unprecedented view into the lifelong process of aging. We created a platform for high-resolution continuous behaviora...

Out now in Science: The Truman Show, but with killifishes!

"Continuous recording of a vertebrate’s adult life from adolescence until death would provide a complete view into the behavioral architecture of aging."

www.science.org/doi/10.1126/...

An algorithm underlying directional hearing in fish Veith et al. show how a fish—Danionella cerebrum—can reliably startle away from sound. It uses the relative phase between particle motion and pressure to infer the direction of sound. This sensorimoto...

How do fish localize sound without interaural cues? @johve.bsky.social et al. found a behavioral algorithm for directional hearing that predicts behavior from a pressure/motion phase comparison and accounts for how this relationship varies with distance. www.cell.com/current-biol...

First whole-brain recording of social sound processing in a vertebrate. Surprises start in the hindbrain; thalamus gates conspecific calls; male and female brains diverge downstream. Work by @joerghenninger.bsky.social, @mh123.bsky.social sky.social and team. www.biorxiv.org/content/10.6...

Astrocytes orchestrate oxytocin’s social effects in mice The cells amplify oxytocin—and may be responsible for sex differences in social behavior, two preprints find.

“Astrocytes in the lateral septum may explain, or be at the basis of, the sex differences we observe in terms of social fear.” –Alexandre Charlet.

By Holly Barker

www.thetransmitter.org/spectrum/ast...

An exciting study with Roberto Garza and Armin Bahl
biorxiv.org/content/10.6...
We combine high-throughput behavioral assays in larval zebrafish with drift-diffusion modeling studying integration dynamics across development and a variety of mutants . Give it a read :D

Check this out! Latest collaborative work from my and Mark Fishman's labs - led by Roy Harpaz, with help from Pedro Piquet and Yasuko Isoe (@yasukoisoe.bsky.social)

Have you ever wondered how the brain should represent the sensory world in order to generate behavior? Read our new preprint: work by Shuhong Huang shuhonghuang.bsky.social with our long-standing collaborator James Fitzgerald at Northwestern.

“ok so this is embarrassing but just for the record and just so we have it, your C.V says "Nature Scientific Reports"? sorry to have to even ask”

😂

Excited to share our new preprint! We explore the link between the locus coeruleus (LC) and arousal for astrocytes, pyramidal cells, interneurons in the hippocampus. A fantastic collaboration with @sianduss.bsky.social @bohaceklab.bsky.social, and many others: www.biorxiv.org/content/10.6... 1/5

Supplementary figure 16

fish remaps 180º visual space onto the full neural compass

Instead, fish seemed to remap 180º of the visual space onto the 360º extent of their neural compass, effectively "considering" the two suns as an identical object. This shows the surprising capacity of the HD cells to rapidly pick up the correlation structure of the visual inputs.

Astrocytes and neurons exhibit partially shared but distinct composite receptive fields for natural stimuli | Journal of Neurophysiology | American Physiological Society Astrocytes are increasingly recognized as active participants in sensory processing, but whether they show selective responses to stimulus features, analogous to neuronal receptive fields, is not yet ...

Lu, Schultz, Kozlov, Astrocytes and neurons exhibit partially shared but distinct composite receptive fields for natural stimuli
Now published in J Neurophys
journals.physiology.org/doi/abs/10.1...

Cool work!

In @elife.bsky.social: Pallium-encoded valence-specific chemosensory amplification of eye-body coordination in larval zebrafish doi.org/10.7554/eLif...

Plastic landmark anchoring in zebrafish compass neurons Nature - Using two-photon microscopy with a panoramic virtual reality setup, how head direction cells in larval zebrafish integrate visual landmarks and optic flow to track orientation is revealed.

1/6: New publication from the lab: “Plastic landmark anchoring in zebrafish compass neurons” by Ryosuke Tanaka (@ryosuketanaka.bsky.social) and Ruben is available here:
rdcu.be/eX1L4

Pattern of pyramidal neurons in brown and black with white lines

Okay, well, I painted some new neurons in burnt sienna and black #sciart

1/n: A new collaborative preprint from the lab to start the year: "A multi-ring shifter network computes head direction in zebrafish" together with Siyuan Mei, Martin Stemmler and Andreas Herz from the LMU, Munich.

Surprise mother$#@%er!

Q: What does this mean for neural systems to understand them?

A: We absolutely need the wiring diagram. All synapses, chemical and electrical.

#Connectomics

Leveraging insights from neuroscience to build adaptive artificial intelligence Nature Neuroscience - Adaptive intelligence envisions AI that, like animals, learns online, generalizes and adapts quickly. This Perspective reviews biological foundations, progress in AI and...

Interested in the latest advances in neuroscience (neural dynamics and internal models) and how they can be leveraged to build smarter, adaptive AI?

➡️ My first real solo piece 🖤🫶 @natneuro.nature.com

rdcu.be/eWVmA

How heterogeneity shapes dynamics and computation in the brain Much effort has been spent clustering neurons into transcriptomic or functional cell types and characterizing the differences between them. Beyond sub…

"My New Year's Resolution is to find a principled way to think about all those cell types in the brain"

Why friend, you are in luck, because @rgast.bsky.social has just the perspective for you: www.sciencedirect.com/science/arti...

Glutamate is the primary molecule that neurons use to communicate with each other.

Previously, scientists have mostly recorded when neurons fire output signals, but now with a new glutamate indicator, they can record the many inputs that causes cells to fire. 🧵

#neuroskyence

I don't always get pretty, isolated, AND transfected primary neurons in culture, but when I do I take advantage.... Rat hippocampal neuron overexpressing ThymosinB4-mScarlet and imaged for 16hr on a @zeiss-microscopy.bsky.social LSM880 with Airyscan. #FluorescenceFriday #Microscopy

Merry Christmas, Hanukkah, et al.