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Posts by Jacob Tennessen

Fig 1A from Daron et al 2026 showing ecologically divergent collection sites in Gabon

Fig 1A from Daron et al 2026 showing ecologically divergent collection sites in Gabon

New paper! How do malaria-transmitting mosquitoes adapt to distinct urban, rural, and forest habitats within a tiny African country? Whole genome sequencing and pop gen reveals their secrets. 🦟🇬🇦🦟
onlinelibrary.wiley.com/doi/abs/10.1...

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This Scientist Brewed and Drank His Own 'Vaccine Beer' to Combat a Dangerous Virus. It Seems to Have Worked Blood tests revealed that the beverage elicited an immune response, according to preliminary research. But far more safety and efficacy testing would be needed before this vaccine could become availab...

No word on whether it vaccinates you against vector-borne diseases www.smithsonianmag.com/smart-news/t...

5 days ago 2 1 0 0
Cans of vicious mosquito IPA

Cans of vicious mosquito IPA

New beer for vector biologists just dropped

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Canonically angels predate the creation of the Earth (Job 38) which suggests Yahweh at some point looked at an angel and thought, you know those feathery appendages? What if I made a whole class of beings out of that material?

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Brewing Immunity: The Vaccine Beer Experiment - Promega Connections A virologist’s “vaccine beer” experiment raises questions about oral vaccines, self-experimentation, and how immunization might evolve.

This is kind of wild 🍻
www.promegaconnections.com/the-vaccine-...

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Missing square illusion such that four irregular shapes are arranged into two triangles of seemingly identical size and shape, except one has a section missing.

Missing square illusion such that four irregular shapes are arranged into two triangles of seemingly identical size and shape, except one has a section missing.

This illusion is basically how music works. Why do three major thirds make an octave? It feels like a perfect fit, an elegant natural resonance, but it's really a trick made by bending things so slightly our brains don't notice. The top hypotenuse isn't straight, and the notes don't really add up.

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Insecticide resistance in South American mosquitoes portends trouble for malaria control

So here’s some good science journalism, with the hope that it will only help us make the world better:

www.cidrap.umn.edu/malaria/inse...

theconversation.com/mosquitoes-c...
(mine, but props to the editors for help)

elpais.com/america-futu...
(Spanish)

g1.globo.com/meio-ambient...
(Portuguese)

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NY headline: Many Rare Mutations May Underpin Disease

NY headline: Many Rare Mutations May Underpin Disease

Nick Wade name-dropped me in the NY Times. Two years later he wrote a book claiming racism is scientifically justified. Our work comparing white and Black exomes did not at all support this, but his sinister interest in it was now clear. His book helped launch the alt-right movement and here we are.

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One reporter was writing about our study and a similar study on genetics of human twins. I answered a few confusing questions about twins on the phone, and later realized they thought I was an author of the other study. Their final article suggested they never really cleared that up.

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Science article: Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes

Science article: Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes

I really appreciate the science journalism surrounding our recent South American mosquito paper. I've had several positive interactions with journalists following up and double-checking things to ensure the facts are correct. Contrast that to my 2012 human exome paper (brief thread)...

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Insecticide resistance in South American mosquitoes portends trouble for malaria control

www.cidrap.umn.edu/malaria/inse...

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Redwood National Park and thereabouts

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Animals I saw in the wild *today* include:
Black bear
Roosevelt elk
California sea lion
Raven
Pacific wren
Banana slug

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A man peering through a gap in a large tree

A man peering through a gap in a large tree

Redwoods! My head for scale.

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A metal monument to “Genetics” at the Clark R. Bavin National Fish and Wildlife Forensic Laboratory

A metal monument to “Genetics” at the Clark R. Bavin National Fish and Wildlife Forensic Laboratory

Thinking of getting one of these for the front lawn

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Malaria-transmitting mosquitoes in South America evolving to evade insecticides | Harvard T.H. Chan School of Public Health Anopheles darlingi mosquitoes—a major vector of malaria in South America—are evolving in response to insecticides, which may make them harder to kill and malaria more difficult to control, according…

We are excited to share groundbreaking new malaria research from the Neafsey Lab, which found that Anopheles darlingi mosquitoes are evolving to invade insecticides.

2 weeks ago 3 1 1 0
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Full frontal Swampy

Full frontal Swampy

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Life-size sculpture of Swampy, a horse-like molluscivore

Life-size sculpture of Swampy, a horse-like molluscivore

Awesome speculative biology art at Southern Oregon University

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2026 Biology of Host-Parasite Interactions Conference GRC The 2026 Gordon Research Conference on Biology of Host-Parasite Interactions will be held in Newport, Rhode Island. Apply today to reserve your spot.

I'll be at this conference in June, who else?
www.grc.org/biology-of-h...

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Fisher's method - Wikipedia

All scientists should know how to combine p-values from two independent experiments. I've had too many conversations with accomplished researchers who still do this on vibes alone ("if it shows the same trend twice, then it must be true!"). Learn Fisher's method.

en.wikipedia.org/wiki/Fisher%...

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AIDS is now referred to as HIV Stage 3 because treatment permits living with the disease, and the word AIDS has heavy connotations of terminal illness. Linguistically, nobody has AIDS anymore.

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I know there’s a lot going on, but it’s weird that there’s been so little hype about the moon mission. A lot of folks will hear of it for the first time tomorrow and assume it’s a joke.

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(however, none of these have been as popular on social media this week as caterpillar butts)

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Population genomics of Anopheles darlingi, the principal South American malaria vector mosquito Malaria in South America remains a serious public health problem. Anopheles (Nyssorhynchus) darlingi is the most important malaria vector across tropical Latin America. Vector-targeted disease control...

New stuff from me in the past week, ICYMI:

1. Science paper on mosquito population genomics: www.science.org/eprint/VRMSQ...

2. Article in The Conversation about insecticide resistance: theconversation.com/mosquitoes-c...

3. Religious service about biology and gender: uucvan.org/services/the...

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The Science and Humanity of Gender - Unitarian Universalist Church of Vancouver Biology teaches us that males and females form part of a continuous spectrum rather than a rigid binary. Come celebrate the diversity of nature, including human nature, that transcends simple classifi...

Yesterday I had the honor of delivering a sermon on the science and humanity of gender. Here's the whole thing, in both audio and pdf formats.
uucvan.org/services/the...

3 weeks ago 4 1 0 0

anopheles! anopheles! anopheles!

🦟 🦟 🦟 🦟 🦟

@godoglyness.bsky.social

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Mosquitoes carrying malaria are evolving more quickly than insecticides can kill them – researchers pinpoint how Once-lethal insecticides now require concerningly high concentrations to effectively kill mosquitoes. Some mosquitoes are already immune to all classes of insecticides used to control malaria.

Don't miss my essay in @us.theconversation.com on the battle against rapidly-evolving mosquitoes.
theconversation.com/mosquitoes-c...

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The rattler I drew is still cartoony, but I tried to be more biologically accurate than the original flag. They don’t stick their fangs and tongue out at the same time, and they don’t make that sproingy spring shape.

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I would hang a pride/gadsden flag outside my house, but I have yet to find one suitable for outdoor use. The snake is super popular in libertarian-leaning southwest Washington. It’s oddly seen as right-wing but there’s no good reason for that: the message is essentially synonymous with “No Kings”.

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Poster with a snake on a progress pride flag that says: don’t tread on anyone

Poster with a snake on a progress pride flag that says: don’t tread on anyone

Prepping for tomorrow

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