Review: Pathogenic and genetic landscape of Still’s disease across ages, with new insights into age-related IL-18 patterns @grantschulert.bsky.social @cincyresearch.bsky.social
link.springer.com/article/10.1...
Here we see specific patterns on xenon MRI in SJIA patients with known lung disease. First step in moving this to regular practice!
How to we best screen for and monitor SJIA-LD? Short: IDK. Chest CT is gold standard but there is reluctance to scan kids serially. So can we use new approaches like MRI?
New online: Xenon MRI in systemic JIA-associated lung disease (SJIA-LD), led by my friend @llwalkup.bsky.social and many others at @cincyresearch.bsky.social
onlinelibrary.wiley.com/doi/abs/10.1...
My first Chair of Pediatrics Dr Gitlin would say “there are children in our hospital right now, who are never going home.” And that is want motivates the work we do ❤️
Someone should remind Pam Bondi that she now qualifies for a 60-day Special Enrollment Period to enroll in an ACA individual market healthcare policy.
Healthcare.gov
Opening session of ACR #PRSYM2026. Fun fact: this is my first PRSYM!
NEWS: The NIH just announced a $150 million investment in developing alternatives to animal testing. Here's my @nytimes.com piece about how a GOP strategist and cat lover pushed MAGA to embrace animal rights. (Hint: it involves Fauci and "transgender mice")
www.nytimes.com/2026/03/12/u...
And thanks to our partners at Sobi for their support of PREIM!
Inspired by our PReS / EMERGE colleagues and #YIM, we aim to build community and highlight amazing science from trainees, fellows, and early career scientists in our field. Let’s go!
Good morning from Minneapolis and the first ever CARRA Pediatric Rheumatology Early Investigator Meeting (PREIM)
Assessing the physician global assessment of lung disease for measuring systemic JIA–associated lung disease activity among pediatric rheumatologists and pulmonologists in the US showed acceptable validity & reliability
ACR Open Rheumatology
doi.org/10.1002/acr2...
Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers.
The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇
Really enjoyed this read from @baseballprospectus.com and Steven. And a reminder that prepping for my fantasy draft isn’t the only reason I’ve been a subscriber for a decade.
www.baseballprospectus.com/news/article...
Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success. Data source: https://report.nih.gov/nihdatabook/report/302
The data is in: the NIH goalposts have shifted.
What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards.
Another manifestation of how HHS policies have led to fewer awards and less science.
There is a reason the Surgeon General is and has always been a actively practicing and licensed physician. It is not a health policy job but one that speaks directly to the direct medical care of Americans.
I have nothing but grace for those who choose to take a leave from residency or leave all together. Many I know and love have made this incredibly difficult choice that this specialty or clinical medicine in general isn’t the life they want. It is *not* a sign of weakness. BUT:
You may know my friend @labwaggoner.bsky.social as the best source of science content on here. : join me in congratulating him for being recognized with the CCHMC @cincyresearch.bsky.social Outstanding Mentorship Award!
Important new work from my friends at NIAMS including Mike Ombrello and Mariana Marques, and a clue to why some SJIA / Still’s patients are weird and different:
Type I interferon signature in Still’s disease. ISG-28 scores from healthy subjects12 and Still’s disease patients are displayed in Panel A. The upper limit of the 95% confidence interval in healthy subjects defined the upper limit of normal as 734.4. Patients with ISG-28 scores above that threshold (high ISG-28) are marked as solid red dots. B. Expression of MX1 and CXCL9 are plotted against one another. C-D. Spearman’s correlation of the ISG-28 with expression of CXCL9 and MX1, respectively. E-F. Violin plots display interferon alpha-specific (E) and interferon gamma-specific (F) genes in Still’s patients with and without high ISG-28. Comparison between group with high and low interferon performed by Mann-Whitney U test. G. Clinical features are projected onto plots of ISG-28 score, shown in logarithmic scale to facilitate visualization. Each phenotype is graphed separately, with phenotype frequencies of the high ISG-28 and low ISG-28 groups
A subset of patients with Still’s disease shows high type I IFN gene signature assoc with lung disease and drug-assoc immune reactions to IL-1/IL-6 inhibitors, which was linked to enrichment of rare genetic variation in IFN-related immune pathways
Arthritis & Rheumatology
doi.org/10.1002/art....
The largest federal prison in the nation is Fort Dix, which has a rated capacity of 4,600 people. The largest of these warehouse camps may hold more than twice that number of people.
The federal government hasn't operated a prison camp inside the United States that large since Japanese Internment.
Sir Ian McKellen performing a monologue from Shakespeare’s Sir Thomas More on the Stephen Colbert show. Never have I heard this monologue performed with such a keen sense of prescience. Nor have I ever been in this exact historical moment.TY Sir Ian, for reaching us once again.
#Pinks #ProudBlue
You walk into this bar and show your ICE mugshot, you don't pay a dime.
I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good.
Stay free
The US government has lost more than 10,000 people with PhDs in the STEM or health fields since Trump 2.0 took office — 14% of the federal civil servants with PhDs in those areas, a @ScienceMagazine analysis shows.
What could possibly go wrong? www.science.org/content/arti...
