Localizable Fluorescent Metal Ion Indicators With Tunable Colors A modular platform enables the generation of fluorescent metal ion indicators with tunable emission colors and precise subcellular localization. Conjugation to self-labeling proteins yields bright, c...

Localizable fluorescent metal ion indicators galore: advanced.onlinelibrary.wiley.com/doi/10.1002/...

Our new paper in ChemistryEurope applies electric-field catalysis under organic synthesis conditions to Jørgenson-Hayashi-type chemistry.

With amines separated from acids, EFC mechanisms with prolinol ethers differ from prolines:

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Tailoring Metal Nuclearity of Pt/γ‐Al2O3 Catalysts: When Molecular Precursors Matter Optimizing Pt/γ-Al2O3 catalysts by surface organometallic chemistry: the MeCpPtMe3 precursor excels in isolating Pt single atoms post-calcination, more than tmedaPtMe2 and CODPtMe2. Reduction forms s...

Synthesizing Pt/γ-Al2O3 materials, ubiquitous in heterogeneous catalysis, with well-defined Pt nuclearity remains challenging. In this work, we demonstrate how SOMC can be employed to tune cluster size down to single atoms.
@chemistryeurope.bsky.social

doi.org/10.1002/cctc...

Günther Maier in Tenerife in February 2007. From his LiC autobiography, Fig. 7.8.

Some of Günther Maier’s highlights from 60 years. From his LiC autobiography.

🌻Rest in peace, Günther Maier. The chemist who made one “impossible molecule” after another died on April 10 at the age of 94. He was a modest man who trained a large number of PhD students. His achievements were recognized with the Adolf von Baeyer Memorial Medal of the GDCh. l-i-c.org/1125

Woohoo. It is finally out! @ezc-group.bsky.social @standrewschem.bsky.social @standrewsosc.bsky.social

Meet #sodium’s new #partnership with #silicon to promote regioselective #arene (multi)silylations @angewandtechemie.bsky.social An exciting synthetic and #mechanistic study byDavid Sanchez-Roa and Sophia Belrhomari @unibe.ch with Max Garcia Melchor and his team #openacess

doi.org/10.1002/anie...

Photocatalytic Vanadium‐Mediated Amination of Benzene With Hydroxylamine Photochemical activation of N-phenylphenothiazine (PPT) enables a selective direct benzene amination with hydroxylamine in the presence of various vanadium catalysts under mild reaction conditions. S...

Our combination of metal- and photocatalysis enables the selective synthesis of aniline under mild conditions and allows easy scaling with flow systems. Nice team work!
#ChemSky #photocatalysis
doi.org/10.1002/chem...

This is a very special moment for us, a big old dream come true: Our new paper in JACS Au provides the conceptual mechanistic framework for electric-field catalysis (EFC) at high voltage under practical organic synthesis conditions.

Thank you JACS Au (GOA, ACS): pubs.rsc.org/en/content/a...

‼️ Last chance to register for the SCS Spring Meeting 2026 ‼️
🗓️ April 23, University of Fribourg, Department of Chemistry
➡️ Register until at latest April 13: sm26.scg.ch/registration
#sm26 #scs #chemistry #switzerland

Tungsten Electrochemistry in Organic Synthesis!

In our latest @chemrxiv.org, we present an exciting collaboration with Merck US. An 18-month project carried out by (now Dr.) Nikola Petrovic

Buckle up, story time! (1/n)

chemrxiv.org/doi/full/10....

Our perspective charts the potential of water as a programmable reaction medium using compatible catalysts, EDA complexes, engineered micelles and microdroplets.

Aqueous-phase organic photochemistry: Distinct modes and interfaces
#ChemSky #photochemistry #watersoluble

doi.org/10.1016/j.ch...

A Bicyclo[1.1.1]pentane-Based Rigid Linker for the Construction of Nitrogen-Rich Energetic Materials Highly strained frameworks have emerged as promising platforms for improving the energy and safety of energetic materials. Herein, three bicyclo[1.1.1]pentane-based energetic compounds bearing nitroge...

OH
MY
HELL
NO
#ChemSky

N-Heterocyclic allenes can be made using a Ti vinylidene complex. Work by Bastiaan Kooij with support from Damien Chen (computations), Rosario Scopelliti (XRD) & Farzaneh Fadaei-Tirani (XRD). Out in @angewandtechemie.bsky.social : onlinelibrary.wiley.com/doi/10.1002/...

Diastereoselective Synthesis of Housanes via the Carbocupration of Cyclopropenes Strained bicyclic frameworks have emerged as valuable isosteric replacements and synthetic platforms based on strain-driven reactivity. The bicyclo[2.1.0]pentane, “housane”, a highly strained, nonsymm...

Our last work on housanes is now published in JACS!
pubs.acs.org/doi/10.1021/...

📣 Job Offer: Professor of Synthetic Organic Chemistry and Professor of (Bio)Analytical Chemistry @ethz.ch
🗓️ Deadline for applications is May 31, 2026
📥 apply online via www.bi.id.ethz.ch/recruiting_a...

#lcsojournalclub | LCSO Lab #LCSOJournalClub 222.1 (highlighted in picture) A total synthesis of scandine reported by Satoshi YOKOSHIMA and co-workers from Nagoya University in JACS Au https://lnkd.in/d2AMMaAi 222.2 A Pd-catalyz...

#LCSOJournalClub edition 222
www.linkedin.com/feed/update/...

Our work on self-optimizing electrochemical reactions is now online (Open Access) on @cp-chem.bsky.social

Check it out:

doi.org/10.1016/j.ch...

Potassium tert-Butoxide: Solubility, Solution Structure, and Reactivity Fundamental properties including solubility and structure–reactivity correlations of potassium tert-butoxide (KOtBu) are described in this manuscript. A combination of donor solvent titration, diffusion NMR, and DFT studies established that KOtBu exists in one of three solution structures: (1) unsolvated cubic tetramer in non-Lewis basic solvents, (2) disolvated cubic tetramer in Lewis basic solvents, and (3) solvated monomer in protic solvents. These studies dispel the notion that strong aprotic donor solvents lead to deaggregation of KOtBu cubic tetramer. In DMSO, a concentration-dependent equilibrium mixture of bis-DMSO-solvated cubic tetramer, dimsylpotassium, and tert-butanol is formed. Donor solvent association with potassium was contextualized in terms of periodic trends within the alkali metal series. The previously reported 1:1 complex of KOtBu and tert-butanol was found to be highly insoluble and affords poor availability of KOtBu when employed in a model dehydrohalogenation reaction. Reactivity can be recovered by the inclusion of strongly Lewis basic donor solvents that disproportionately stabilize the transition state.

So you think you know KOtBu…
Well my colleagues in #PfizerChemistry process chem have done some amazing work to find out a lot more about a very useful base #ChemSky

#lcsosynthesisproblem #lcsosynthesisproblem | LCSO Lab #LCSOSynthesisProblem is back this week, where Clément has challenged us to the total synthesis of (±)-Lundurine B by Nishida. 💡 Want to challenge yourself or your team to this synthesis problem? Che...

Next edition of #LCSOSynthesisProblem
www.linkedin.com/feed/update/...

Armin de Meijere at his 80th birthday celebration · photo by Eva E. Wille

📅 Lutz Ackermann, Peter Gölitz, Dieter Kaufmann, and Oliver Reiser have organized an Armin de Meijere Memorial Symposium, “From Small Rings to Large Compounds”, which will take place on May 22, 2026, at the University of Göttingen. Registration required (see program l-i-c.org/news-events....).

Accessing CF3-Cyclopropenes ─ A Platform for the Synthesis of Trifluoromethylated Building Blocks Cyclopropenes are the smallest unsaturated carbocycles. They possess exceptionally high ring strain, resulting in unique reactivity, enabling C═C bond functionalization and ring-opening transformation...

The work of Josh, Tobias and Matthew on the synthesis of CF3-cycloproprenes using hypervalent iodine reagents and Cu(III) complexes is now published in Org. Lett.
doi.org/10.1021/acs....

Our preprint on the total synthesis of pabmaragramin is now available on ChemRxiv! Dive into the fascinating world of scalemic natural products and chiroselectivity.
chemrxiv.org/doi/full/10....

Electroreductive Cleavage of C(sp3)–N Bonds in Saturated N-Carbonyl Heterocycles Ring-opening C–N bond cleavage reactions provide an effective means to convert widespread, readily accessible chiral N-heterocycles into hard-to-attain stereodefined linear amines. Current strategies either rely on the strain-induced release of small aziridine and azetidine rings or, for larger ring systems, require highly electrophilic reagents, oxidative conditions, or preinstalled reactive functionalities to enable the ring-opening event. Recently, complementary radical strategies that exploit the reactivity of α-amino-ketyl radicals, formed upon single-electron transfer (SET) reduction of common N-carbonyl protecting groups, have emerged. Nevertheless, these methods facilitate the homolytic fragmentation only of up to 5-membered azacycles. In this study, we leveraged electroreductive conditions to switch the nature of the above C–N bond cleavage manifold from radical to ionic and enable the heterolytic ring-opening of a broad array of unstrained cyclic amines (comprising pyrrolidines, piperidines, azepines, azocanes, and N-macrocycles), protected as N-(thio)amides, carbamates, or ureas. Crucially, this electrochemically enabled reactivity switch grants complementary functional group compatibility and a broader ring size and N-carbonyl group scope. Computational and experimental studies indicate that electrochemical settings are crucial for generating the Mg(II)-Lewis acid catalyst, activating the N-carbonyl moiety while prompting the so-formed oxy-iminium ion intermediates to undergo two consecutive cathodic SET reductions, generating “umpoled” α-amino-α-oxy-carbanion species. These, via irreversible E1cB fragmentation of the adjacent C–N bond, lead to the desired ring-opened products. Our electrochemical procedure can be scaled up and miniaturized (enabling its application to high-throughput experimentation screening), and its synthetic utility has been demonstrated by accessing decorated stereodefined linear amides from stereochemically rich pyrrolidine and azepane derivatives.

Excited to see our recent work on the electroreductive cleavage of C(sp³)–N bonds in saturated N-carbonyl heterocycles out in @jacs.acspublications.org 🔌Check the full study here: pubs.acs.org/doi/10.1021/...

A post-doctoral position (topic: main-group chemistry and @boron-chemistry.bsky.social boron chemistry) funded by @erc.europa.eu (ERC Research 🇪🇺 🇧🇪; project B-YOND) is available in the group. Applications until April 15ᵗʰ 🗓️. 🔽See details below.⬇️ Please RT✔️. Link: euraxess.ec.europa.eu/jobs/417016.

Next organic seminars at EPFL Chemistry with Prof. Daniel Weix from the university of Wisconsin Madison | LCSO Lab Next organic seminars at EPFL Chemistry with Prof. Daniel Weix from the university of Wisconsin Madison

Organic seminar today at EPFL with Prof. Daniel Weix @weixgroup.bsky.social
www.linkedin.com/feed/update/...

Isomerization and Dimerization of 1-Phenylpropyne upon Metalation with Alkyl Lithium Bases and Lewis Basic Polyamine Donors Since the isomerization of C–C multiple bonds is a powerful strategy in organic synthesis, in this study we have investigated the isomerization upon metalation of 1-phenylpropyne with alkyllithium bas...

We have our first publication from Fribourg! So happy that is also in Organometallics, one of my favourite journals 😊 pubs.acs.org/doi/full/10....
Congrats to @mikaelleroch.bsky.social and thanks to @unifr.bsky.social chemistry department and everyone made it possible!

Nitrogen, Ammonia, and the Strait of Hormuz

Chemistry in current events: the connections between fertilizer, the Haber-Bosch process, and the Persian Gulf. Read this and your knowledge will exceed that of most of our current political leadership after only a few minutes of light work:

Speciation, Structural Refinement, and Distribution of Ti Sites in Titanium Silicalite‐1 From 47/49Ti NMR Crystallography at 28.2 Tesla Titanium silicalite-1 (TS-1), used in industrial selective oxidation processes, depends on specific, yet still unresolved Ti sites, dispersed within the framework of an MFI-zeolite. Applying high fie....

47/49Ti NMR Crystallography enables to refine the speciation, distortion and distribution of Ti sites in Titanium Silicalite-1, a prominent catalyst for sustainable selective oxidation reactions
doi.org/10.1002/anie...

🚀 Great news for chemical research!

💻 Release of #Chemotion #ELN 3.0.0 out! 🎉 The latest update to our electronic laboratory notebook brings numerous improvements and new features that make managing your research data even more efficient and #FAIR.

👇 https://t1p.de/0lk2o

#Chemistry

The LCSO research website has been updated with our last results: Have a look to learn more about our research from 2007 to 2026! Overview: https://lnkd.in/eWEtDkMR Electrophilic alkynylation:… | LCS... The LCSO research website has been updated with our last results: Have a look to learn more about our research from 2007 to 2026! Overview: https://lnkd.in/eWEtDkMR Electrophilic alkynylation: https:...

The LCSO research website has been updated!
www.linkedin.com/feed/update/...