Thank you for posting!

🚨Please share! We are hiring a post-doc! 🪱 🐀
Job posting: www.training.nih.gov/jobs/pdf-gb-...
Lab Website: www.niddk.nih.gov/research-fun...
NIH Trainee info: www.training.nih.gov

Doctor Behind Award-Winning Parkinson’s Research Among Scientists Purged From NIH Leading scientists at the National Institutes of Health, the US’s leading medical research agency, were swept up Tuesday in the Trump administration’s latest firing blitz.

www.wired.com/story/doctor...

Congrats David!! Excited to see what’s to come!

Here, through whole animal scRNA-seq, neuropeptidomics, and genetic screens awesome post-doc, Carrie Sheeler, answers those questions! Thank you collaborators @jennifergarrison.bsky.social 's lab and Kenyon lab!

Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans Organismal protein homeostasis and longevity in nematodes are coordinated by a subtype of glia.

I previously found that subtype of four astrocyte-like regulate organismal ER stress resistance and longevity.
science.org/doi/10.1126/...
However, the signal and full extent of the cell non-autonomous response remained unknown.

Excited to share another pre-print from our lab! We found a neuropeptide that can cell non-autonomously activate the ER-UPR and protect animals from proteotoxic stress.
www.biorxiv.org/content/10.1...

Congrats to Karmen Mah and Adam Roszczyk who figured out this initially puzzling observation! 🥳

· Mice with maternally inherited hGFAP-creERT2 exhibited no Cre-mediated recombination
· Recombination was robust in mice with paternally inherited hGFAP-creERT2
· Inheritance effect is NOT transgenerational
· Suppression of recombination was observed independent of colony.

GFAP-CreERT2 mice. Maternal inheritance suppresses transgene recombination efficiency in astrocytes.

A PSA for #astrocyte aficionados working with GFAP-CreERT2 mice from @jacksonlab.bsky.social (#012849)

Parental origin of transgene determines recombination efficiency in GFAP-creERT2 mice The Cre-loxP system is a powerful tool for spatial and temporal genetic manipulations. However, the system is prone to several limitations and caveats with respect to variable expression and recombina...

Happy to share a recent pre-print from our lab!
Parental origin of transgene determines recombination efficiency in GFAP-CreERT2 mice
www.biorxiv.org/content/10.1...