And yet, while I do understand the anger and all, I wish: 1) he had been tried in a court of law and received a life sentence for crimes against humanity rather than executed under mysterious circumstances; 2) the crowed had been slightly more civilized. And I say this as an Italian and antifascist

Man, I like this new Pope!

Has anyone yet made a montage of the #ArtemisII photos from the dark side of the Moon with The Great Gig in the Sky for soundtrack?

can someone tell him he doesn't need to sign his tweets with his full name and job title? Tweets are literally like "letterhead" kinda messages.

congrats!

GUYS THEY'RE ALMOST BACK FROM BEHIND THE MOON, EVERYONE HIDE

Earth and Moon from DSCOVR NASA's Earth Polychromatic Imaging Camera (EPIC) aboard the Deep Space Climate Observatory (DSCOVR) satellite captured this unique view of the Moon as it moved in front of the sunlit side of Earth last month. This view shows the fully illuminated “dark side” of the moon that is never visible from Earth. Ian Regan processed this version of the image to account for the Moon's motion. NASA / NOAA / Ian Regan

I hadn't seen this before. This is pretty remarkable.

Earth and Moon in one NASA photo.

ht @astrokatie.com

Someone on Twitter tweets: "I noticed Gen Z people don't carry umbrellas. They just walk in the rain lol"

you don't need an umbrella when all your clothes are made from plastic

my question is: how are PTC committees going to take all this into account when evaluating folks that are starting now-ish for tenure in 4-6 years time? Or even this year or next, how are folks hired ~5 years ago and unable to get a renewal going to be evaluated? It's going to be tough.

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I am confused. Since the impact factor is calculated from the total number of citations of the journal as a whole, is in it a bit misleading to draw any conclusion other than: x correlates with f(x)?

I don't think AI is always bad, let's try to see it as a tool that can help us reach higher, rather than try to compete with it (also because if we compete, one day we'll lose)

Not everyone can hire a professional illustrator (well, I tried for years to get my talented artistic nephew to do it, but he wasn't interested).

I respectfully disagree. As always, in medio stat virtus. I got some help from AI to design my lab logo, I modified a bit what AI had originally produced which was a good start, and i like the final result.

Don't get me wrong, I always welcome an excuse to eat chocolate but... jeeez, have you looked at those effect sizes? seriously?

Look, this is a fascist gvt, and this guy is an incompetent fascist. But that gesture is being inflated. He was just pointing while talking, it's pretty clear.

Best exam answer, ever! 😆

There are no assays that measure the effect of disrupting WASF3 in vivo in a relevant animal model. There's one experiment, the treadmill, which says absolutely nothing about the kind of chronic fatigue experienced by patients with ME/CFS or Long Covid.

which is a very beautiful WASF3/mitochondria paper but not an ME/CFS or Long Covid paper, not even close. Moreover, in that paper they only show the effects of UDCA in cells, it's a long shot to give it to patients and hope it'll work. Wow!

But going back to the article, I can see why metformin was tested, it makes sense. Too bad it didn't work. I am not sure what the rationale for ursodeoxycholic acid was?

the most likely explanation is a combination of all these factors. but really the placebo effect is strong and shouldn't be discarded. That's why clinical trials should always be placebo-controlled (barring any practical issues with feasibility).

the original post has been deleted, likely for the best. Darn, now I am super curious to know what it was!

blows my mind away - 100% certainty used to occur up to 10%le, now only up to 5%le

The placebo effect is amazing, that's why lots of people believe in bogus medicine

With that said, of course there are biological reasons for histones to be present in serum at high enough levels to be detected, for example if there was lots of cell death. But I would expect that in that case we would have already solved ME/CFS as an autoimmune disorder. Except, we haven't.

The weakness is the same as for an immunoassay: just like no Ab-Ag interaction is 100% specific, same as aptamer-target. So, the hits that one gets with aptamers should be further validated with other methods such as immunoassays and mass spectrometry.

it's an array where the capturing molecules are aptamers, these are DNA molecules that bind to other molecules, such as proteins. From the biochemical point of view it is almost like an immunoassay, except that the capturing molecule is DNA instead of antibody (protein).

on the other hand this was not done with mass spec but with Somalogic, and I am always a bit suspicious about Somalogic findings

Ok, this new thing that the "grey area" proposals (Competitive Non Discussed) get bumped straight to Council without discussion, is total bonkers.