Journal of Molecular Biology (JMB) special issue edited by Lewis E. Kay & Remco Sprangers, NMR studies of biomolecular systems, Volume 437, Issue 23, 1 December 2025 www.sciencedirect.com/journal/jour... #NMRchat 🧲

Making invisible excited state protein structures visible by combining NMR and machine learning NMR relaxation studies of the precursor form of the pro-inflammatory cytokine interleukin-18, pro-IL-18, show that it adopts two sparsely populated (<0.5%) and transiently formed (ms lifetimes) excite...

Jeff & Co. Just finished cooking this up. Give it a read!
👇👇👇👇
www.biorxiv.org/content/10.1...

Functional spectrum of USP7 pathogenic variants in Hao–Fountain syndrome: Insights into the enzyme’s activity, stability, and allosteric modulation | PNAS Hao&ndash;Fountain syndrome is a rare neurodevelopmental disorder caused by mutations in the deubiquitinating enzyme Ubiquitin-Specific Protease 7 (USP7)...

Our latest paper is online today ahead of print in PNAS
@pnas.org

www.pnas.org/doi/10.1073/...

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JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.

www.nature.com/naturecareer...

Please repost!

Trump Administration Puts New Chokehold on Billions in Health-Research Funding The National Institutes of Health can’t award grants to outside researchers under a new White House restriction.

Absolutely outrageous interference in NIH extramural funding by OMB dropping this evening. Damaging to our nation’s world leadership, innovation, and training today and for years in the future. www.wsj.com/politics/pol...

I agree it was quite the shock seeing these prices climb over the last few years. Unfortunately, the companies have no plan to produce more.

We distill our used deuterated media, which works pretty well. I think you can reuse several times, which lowers the initial cost.

NMR-Based Measurements of Site-Specific Electrostatic Potentials of Histone Tails in Nucleosome Core Particles Electrostatics play a dominant role in guiding many biological processes. This is especially the case in the context of chromatin, where charge interactions modulate diverse activities such as DNA rep...

Check out Nick & @roesslph.bsky.social work on nucleosome electrostatics! More to come shortly 👀

#NMRchat

Home - GRASP NMR The 2025 GRASP NMR Symposium will be held October 17-18, 2025 at Iowa State University in Ames, Iowa. Our MissionThe GRASP symposium aims to highlight the pivotal role of protein NMR in integrated str...

Great Plains Regional Annual Symposium on Protein and Biomolecular Nuclear Magnetic Resonance (GRASP NMR)
The 2025 GRASP NMR Symposium will be held October 17-18, 2025 at Iowa State University in Ames, Iowa www.regcytes.extension.iastate.edu/grasp/ #NMRchat #NMR #NMRevents 🧲

UMich Biophysics has an open search for a new faculty member. Application materials are due 5/15. Search is open rank (despite the title in the link). Would love to bring more structural biology colleagues to Biophysics. #NMR careers.umich.edu/job_detail/2...

Opinion | The Authoritarian Endgame on Higher Education This is a moment to trumpet the strengths of higher education and address its weaknesses.

Strong column from @nytimes.com editorial board. “The people who are attacking higher education are talking nonstop,” said Holden Thorp. “And the people leading higher education are not saying very much.” www.nytimes.com/2025/03/15/o...

Goes without saying that this list of schools includes some of the largest recipients of #NIH grants.

Hi Jeremy. I served on MSFB which met last week: 2/11-2/12.

Alexander Hollaender Award in Biophysics – NAS The Alexander Hollaender Award in Biophysics is presented every three years and carries with it a $20,000 prize. The Award recognizes outstanding contributions made to the field of biophysics. Henriet...

Congratulations to Lewis for being awarded the Alexander Hollaender Award in Biophysics! (www.nasonline.org/award/alexan...)

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NIH $ contributed to 354/356 new drugs approved 2010-2019 (pmc.ncbi.nlm.nih.gov/articles/PMC...), among *many* other benefits. Disrupting this discovery engine hurts US science, education, health, and economy.

Concerned? Let your Senators (www.senate.gov/senators) know impact of yesterday's changes

Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring Researchers facing

“The impact of the collective executive orders and directives appears devastating.” scim.ag/40ureTO

Solution NMR goes big: Atomic resolution studies of protein components of molecular machines and phase-separated condensates The tools of structural biology have undergone remarkable advances in the past decade. These include new computational and experimental approaches tha…

HOT OFF THE PRESS!! Alex (@aimsever.bsky.social), Rashik (@rashikahmed.bsky.social) & Philip (@roesslph.bsky.social) review recent advances in biomolecular solution NMR and provide an outlook of what the future holds! Check it out here:

#NMR #NMRchat

Former Kay lab member, Prof. Robert Harkness is recruiting prospective graduate & undergraduate students for his lab @uofguelph.bsky.social! Rob is a great mentor and is an expert in biophysics and data modelling!
#NMRchat
theharknessgroup.com