Complementary Holliday Junction observations now available to absorb from @martinxaver.bsky.social and coauthors!
www.biorxiv.org/content/10.6...

Dear all, please see link below for Milano et al, describing a role for BRCA2 (& BRCA1) in the maturation of nascent DNA strand gaps during DNA replication in the presence of PARP inhibitor. Congratulations Larissa and all !

authors.elsevier.com/a/1mtQe3vVUP...

Exciting work from the Rass lab, and colleagues at the GDSC 🥳

FEN1 is critical for rapid single-strand break repair in G1 phase Abstract. Flap endonuclease 1 (FEN1)-dependent long-patch repair has been considered a minor sub-pathway of DNA single-strand break repair (SSBR), activate

Our latest study is out in Nucleic Acids Research. FEN1 is critical for rapid single-strand break repair in G1 phase url: academic.oup.com/nar/article/...

🗣️ #WomeninScience at IOCB cordially invite you to the next event in the #DanaHockoválecture series by Dr. Hana Hanzlíková ( #UniBern/ @imgprague.bsky.social @czechacademy.bsky.social).

See more ► www.uochb.cz/en/event-cal... ⤵️

EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism - Oncogene Oncogene - EWS::FLI1-DHX9 interaction promotes Ewing sarcoma sensitivity to DNA topoisomerase 1 poisons by altering R-loop metabolism

Our latest study is now online! A great collaboration between the @fgh-lab.bsky.social and @enriquedealava.bsky.social Labs, driven by the outstanding work of J. Olmedo-Pelayo at @ibis-investigacion.bsky.social Check it out!

Well done Larissa, and Isabelle!

Dear all,

Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk

Dear all, over Christmas I was sadly informed that Larry Thompson died on Dec.16th. Those of you that knew Larry and his work will know how big a loss this is to the genome stability community. A brief memoriam and tribute to Larry is available in DNA Repair.
authors.elsevier.com/sd/article/S...

The Genome Damage and Stability Centre at the University of Sussex has now joined BlueSky! Follow us here, for news, views and publications.

This meeting is always very very special…..don’t miss it.

Dear all, my first post! I have postdoc positions available if you would like to join my lab in beautiful Sussex by the Sea! Please contact me on k.w.caldecott@sussex.ac.uk