Clinical trials today are highly bureaucratic, expensive, and time-consuming. Most trials fail to recruit enough participants to answer their questions at all.

This great post by Adam Kroetsch explains how things got this way.

www.clinicaltrialsabundance.blog/p/clinical-t...

Request for Proposals: Generic Drug Repurposing

🚨🚨🚨 Funding call - Generic Repurposing🚨🚨🚨

Coefficient Giving is seeking expressions of interest to fund clinical trials of repurposed generic drugs for high-burden, neglected diseases.

Please see coefficientgiving.org/funds/scienc... for more details!

Agree! Had never realised though until you said it.

And Granny is more of an outsider figure than Vimes. Even the other witches don't quite know where they stand with her.

UK pledges £160 million to boost global vaccine development New funding for the Coalition for Epidemic Preparedness Innovations (CEPI) will speed up vaccine development.

Mad to me that the UK govt has spent £200m on a covid Inquiry but gave CEPI £160m for the next 5 years.
www.gov.uk/government/n...

www.bbc.co.uk/news/article...

Thanks for the great answers!

If you could magically have a new effective vaccine for any infectious disease - which would it be?
Same question for therapy/drug?

If they just did the scotland/England bits first and then stopped they would still have done something useful.

labourlist.org/2026/02/keir...

I think the unity ticket would be Rayner as PM with Ed Miliband as Chancellor?

If you bought a house pre-Truss then you probably got a good deal on your mortgage!

🚨New report with @homesfornorth calls on the government to adopt a novel approach to affordable housing investment:

Giving Homes England a ‘National Affordable Housing Bank’ role to invest alongside the private sector in funds set up to deliver discounted rent homes.

A 🧵on why this is needed:

Where to start with: Terry Pratchett Ten years on from his death and just before what would have been his 77th birthday, take a deep dive into the funny, fantasy works of one of the most loved British writers

Oof felt good to remember reading some of these classics. Night Watch deservedly recognised - my personal favourite.
Where to start with: Terry Pratchett www.theguardian.com/books/2025/a...

Another fascinating generic repurposing potential use case!

GOOD NEWS! Researchers at the University of Buffalo have developed a nanoparticle-based vaccine candidate for H5N1 avian influenza (clade 2.3.4.4b) that achieved 100% PROTECTION in preclinical trials. The vaccine is under development for potential use in BOTH veterinary AND human medicine. 🧪🧵⬇️

Really lovely story to read and definitely recommend his Substack.

Great piece - but what's this about?
"one of the less glamorous teams in the English Premier League"
Total nonsense that 😉

Worrying if true. Brought this quote to mind for me:
"Once men turned their thinking over to machines in the hope that this would set them free. But that only permitted other men with machines to enslave them."

Fascinating piece.
But will helping women have children later really get rid of the motherhood earnings penalty? Your 40s also seem an important time for career as well...

People born in the late 1960s: one of the measles vaccines in use then generated poor immunity. Check your measles titer – or do what I did today: get a booster shot! @adamratnermd.bsky.social

Sounds like sensible pro growth policy. But I think "lab grown" needs a rebrand. Maybe "cruelty free"?

Killing PEPFAR means killing millions of people All to save 0.08 percent of the budget.

“For people like myself who have long taken pride in PEPFAR, it’s been painful and horrifying to watch this lifesaving work grind to a halt without a justification or even acknowledgment that it’s happening.”

Would you agree that at certain moments of severe economic crisis, aid could prevent/ameliorate a severe recession?

The new GOV.UK login system is the first step in a radical transformation of the British state A British "DOGE" (of sorts) is rearchitecting the government

The new GOV.UK login system is the first step in a radical transformation of the British state (FREE TO READ!)

takes.jamesomalley.co.uk/p/login-to-a...

IAVI and Biofabri/Zendal Announce First Vaccinations in the IMAGINE Clinical Trial, a Large-scale Safety and Efficacy Trial of the Tuberculosis Vaccine Candidate MTBVAC

So excited to see this trial start!
www.accessnewswire.com/newsroom/en/...

asm.org/articles/201...

A Defense of Weird Research—Asterisk Government-funded scientific research may appear strange or impractical, but it has repeatedly yielded scientific breakthroughs — and continues to pay for itself many times over.

Powerful defence of basic research (with some fascinating examples)
asteriskmag.com/issues/09/a-...

Interesting research. I think diabetes also linked with increased likelihood of drug resistant TB...

Diabetes potentiates the emergence and expansion of antibiotic resistance Diabetic infections are a reservoir for the emergence and proliferation of antibiotic resistance in Staphylococcus aureus.

𝗣𝗿𝗼𝘃𝗼𝗰𝗮𝘁𝗶𝘃𝗲: 𝗗𝗶𝗮𝗯𝗲𝘁𝗲𝘀 𝗳𝘂𝗲𝗹𝘀 𝗔𝗠𝗥

Staphylococcus aureus evolves antibiotic resistance rapidly in diabetic mice, as hyperglycemia aids the expansion and takeover of resistant mutants

VISA strains have a large fitness defect in control mice but not in diabetic mice

➡️ www.science.org/doi/10.1126/...

Trump’s Foreign Aid Freeze Leaves Millions Without HIV Treatment President Trump’s pause on aid, and the gutting of the primary aid agency, could jeopardize the health of more than 20 million people worldwide, including 500,000 children, experts say.

Two weeks into President Trump’s sweeping freeze on foreign aid, HIV groups abroad have not received any funding, jeopardizing the health of more than 20 million people, including 500,000 children.

Funding Opportunities / RFPs - Cures Within Reach Funding opportunities for clinical trials repurposing research in any unsolved disease.

Research funding opportunities for generic repurposing clinical trials ->
www.cureswithinreach.org/programs/fun...