EBV strain interacts with host HLA to drive nasopharyngeal carcinoma risk - Nature A genome-to-genome association study identifies host and viral risk factors that interact to drive nasopharyngeal carcinoma endemicity in southern China.

new out in Nature www.nature.com/articles/s41...

Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers - Nature Metastasis-associated oncofetal cell states emerge at the earliest stages of colorectal cancer and spatial profiling shows stereotypic patterning of fibroblast subtypes resembling normal tissue archit...

new out in Nature www.nature.com/articles/s41...

A mechanism for adaptive genome regulation in cancer - Nature In this Perspective article, a theoretical framework for how the AP-1 family of transcription factors mediates cellular adaptation in cancer drug resistance is proposed.

a wonderful Perspective article www.nature.com/articles/s41...

Tumour promotion through the lens of evolution - Nature This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable environment...

new out in Nature: wonderful review article on tumour promotion www.nature.com/articles/s41...

Giant cancer study reveals effectiveness of ‘off label’ treatments Hear the biggest stories from the world of science | 15 April 2026

and the podcast www.nature.com/articles/d41...

How effective is the personalized off-label use of targeted cancer treatment? If general cancer treatment fails, a tumour-type-specific therapy might be tried for other cancers with genetic changes in the targeted pathway. How well does this work?

and the News & Views
www.nature.com/articles/d41...

new out in Nature www.nature.com/articles/s41...

Molecular profiling of gene-edited cells reveals shared drug-resistance mechanisms Many genetic perturbations that cause resistance to an anticancer drug do so through common pathways.

and the accompanying Research Briefing www.nature.com/articles/d41...

Mapping convergent regulators of melanoma drug resistance by PerturbFate - Nature PerturbFate is a high-throughput, cost-effective, single-cell platform that systematically profiles CRISPR interference perturbations to reveal common regulatory nodes and convergent phenotypic states...

new out in Nature www.nature.com/articles/s41...

Ageing promotes metastasis via activation of the integrated stress response - Nature Ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrate...

new out in Nature www.nature.com/articles/s41...

Multidimensional profiling of heterogeneity in supratentorial ependymomas - Nature Individual supratentorial ependymoma tumour subgroups have two distinct progenitor-like cell states—neuroepithelial-like and embryonic-like—that are reminiscent of early human brain development and di...

new out in Nature
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Stress-hormone signalling protects spreading cancer cells from immune system Activation of glucocorticoid receptor in disseminating tumour cells enables them to escape immune detection.

and the Research Briefing to go with it
www.nature.com/articles/d41...

A glucocorticoid–FAS axis controls immune evasion during metastatic seeding - Nature Glucocorticoid receptor activation is a key driver of resistance of triple-negative breast cancer to both CD8+ T cells and natural killer cells during initial metastatic seeding.

new out in Nature (well, last week)
www.nature.com/articles/s41...

Dynamics of circulating tumour DNA can guide treatment decisions for improved outcomes Adapting the therapeutic strategy on the basis of participants’ risk of cancer recurrence improved survival rates.

and the Clinical Briefing to go with it
www.nature.com/articles/d41...

Risk-adaptive therapy guided by dynamic ctDNA in nasopharyngeal carcinoma - Nature A clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows pr...

new out in Nature
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A disease model resource reveals core principles of tissue-specific cancer evolution - Nature The Mouse Cancer Cell line Atlas (MCCA) provides major advances towards a mechanistic understanding of cancer genomes.

new out in Nature www.nature.com/articles/s41...

OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours - Nature The identification of ‘boosters’ that drive gene overexpression directly in a CAR construct provides a simple and scalable strategy for developing effective CAR-NK cell therapies for solid tumours.

new out in Nature www.nature.com/articles/s41...

SLAMF6 as a drug-targetable suppressor of T cell immunity against cancer - Nature SLAMF6 functions exclusively as a T cell inhibitory receptor, which is triggered by cis homotypic interactions.

new out in Nature www.nature.com/articles/s41...

Activated ATF6α is a hepatic tumour driver restricting immunosurveillance - Nature ATF6α activation in human and preclinical models of hepatocellular carcinoma is significantly associated with an aggressive tumour phenotype characterized by reduced survival, glycolytic reprogramming...

new out in Nature www.nature.com/articles/s41...

ZFTA–RELA ependymomas make itaconate to epigenetically drive fusion expression - Nature The ZFTA–RELA fusion, an oncogene for ependymomas, promotes the production of itaconate, and its dependence on this metabolite represents a new therapeutic target for this cancer.

new out in Nature www.nature.com/articles/s41...

How tumours trick the brain into shutting down cancer-fighting cells Lung cancer in mice hijacks neurons to send a signal that subdues the immune system, study finds.

and the new story www.nature.com/articles/d41...

A tumour-to-brain pathway hinders anticancer defences Sensory neurons detect internal and external cues in organs and send this information to the brain. Lung cancer exploits this pathway to lessen immune responses.

and the News & Views
www.nature.com/articles/d41...

Tumour–brain crosstalk restrains cancer immunity via a sensory–sympathetic axis - Nature Mouse models demonstrate that vagal sensory neurons transmit signals from lung adenocarcinoma to the brain, increasing sympathetic efferent activity in the tumour microenvironment and thereb...

new out in Nature, very nice cancer neuroscience story
www.nature.com/articles/s41...

Critical role for a high-plasticity cell state in lung cancer - Nature The high-plasticity cell state (HPCS) is a critical hub that enables reciprocal transitions between cancer cell states, and targeting the HPCS may suppress cancer progression and eradicate treatment r...

new out in Nature www.nature.com/articles/s41...

Temporal tissue dynamics from a spatial snapshot - Nature One-shot tissue dynamics reconstruction can infer changes in tissue composition over time, from single-time-point spatial proteomics of human cancers.

new out in Nature www.nature.com/articles/s41...

new out in Nature www.nature.com/articles/s41...

and the News & Views
www.nature.com/articles/d41...

Nutrient requirements of organ-specific metastasis in breast cancer - Nature How the complex interplay between multiple nutrients within the microenvironment dictates potential sites of metastatic cancer growth is explored.

new out in Nature www.nature.com/articles/s41...

How fasting boosts breast cancer therapy A discovery in mice reveals why fasting enhances a type of breast cancer treatment — a hormone-signalling pathway and gene-expression changes have key roles.

new News & Views out in Nature
www.nature.com/articles/d41... on last week's www.nature.com/articles/s41...

Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity - Nature The ALPK1 agonist UDSP-Hep stimulates tumour-cell antigen presentation, macrophage–DC cross-priming and differentiation of protective memory T cells.

new out in Nature this week www.nature.com/articles/s41...