Genomic uniqueness in the genus Bodo. Species tree inferred by STAG. Tree scale is substitutions per site.
Single-cell sequencing reveals unexpected genetic diversity among Bodo spp. flagellates and their bacterial endosymbionts. Published Open Access and fee-free in MGen using a Publish and Read agreement: https://doi.org/10.1099/mgen.0.001642 #PublishandRead #MGen
🆕T. brucei Kozak sequences are unusual, hard to detect, but important for translation regulation - Check out the work conceived💡, carried out🔬and written up ✍️ by Philip Stettler, with only a minor contributions from me and the Polacek group - CONGRATULATIONS🎉👏 academic.oup.com/nar/article-...
DNA damage drives antigen diversification in Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/41951731/
(1/7) How does T. brucei achieve a 140-fold stoichiometric excess of VSG mRNA over upstream ESAGs from a single polycistronic unit?
Our latest research in @natmicrobiol.nature.com reveals a mechanism of spatially regulated RNA decay to fine-tune expression of virulence genes
A trypanosome trifecta: an independently tunable triple inducible system for genetic studies in Trypanosoma brucei pubmed.ncbi.nlm.nih.gov/41885459/
Sébastien Pomel @univparissaclay.bsky.social and I wrote a review on the relevance of PRMTs for protozoan parasites and their potential as drug targets. Check it out in @microbialcell.bsky.social
We are pleased to share a pre-print of collaborative work @scotomorph.bsky.social @janemunday.bsky.social @keithrmatthews.bsky.social @goldrieve.bsky.social describing the genome of Trypanosoma congolense and the organisation of VSG genes for immune evasion
www.biorxiv.org/content/10.6...
Trypanosome histone variants H3.V and H4.V promote nucleosome plasticity in repressed chromatin pubmed.ncbi.nlm.nih.gov/41709455/
De novo assembly of the Trypanosoma congolense genome reveals an organisation influenced by antigenic variation but distinct from Trypanosoma brucei www.biorxiv.org/content/10.64898/2026.02...
Histone H3 Ser10 phosphorylation occurs exclusively in replicative stages and peaks during mitosis in Trypanosoma cruzi www.biorxiv.org/content/10.64898/2026.02.16.706091v1
Applications are open for the 2026 Biology of Parasitism course!
📍 Woods Hole, MA | 🗓 June 12 - July 23, 2026
An immersive 6-week program in modern parasitology for PhD students & postdocs, co-organized by Stéphanie Blandin.
📅 Application deadline: February 5, 2026
🔗 : shorturl.at/i8GSr
Global Protein Interaction Network for Trypanosoma cruzi pubmed.ncbi.nlm.nih.gov/41407521/
Leishmaniasis pubmed.ncbi.nlm.nih.gov/41266459/
Variation in surface protein expression leads to heterogeneous Trypanosoma cruzi populations during host cell infection pubmed.ncbi.nlm.nih.gov/41224774/
academic.oup.com/nar/article/...
Great to see this out! Big shout out to Douglas Escrivani, Seb Hutchinson & the Horn Lab!
@dundee.ac.uk
@ybri-uoy.bsky.social @york.ac.uk
JCB has rounded up a good collection of papers outlining best practices regarding reproducability in Cell Biology experiments, especially microscopy. Worth a read, and passing along to your trainees.
🧬Aspiring Editors🧬
Access Microbiology is recruiting Editors to join our board! We welcome expertise across all areas of microbiology, and are especially keen to hear from microbiologists working in clinical microbiology or genomics. Feel free to DM with any questions.
How do parasites strategically organise their genomes to influence gene expression? If you’re curious, check our latest review in @cp-trendsparasitol.bsky.social !
@biologyatyork.bsky.social @ybri-uoy.bsky.social @pasteur.fr
www.sciencedirect.com/science/arti...
My attempt to become a professor was unsuccessful again but the diplonema tagging paper is now published in Open Biology. royalsocietypublishing.org/doi/10.1098/...
Intrinsic differences in hamster and mouse macrophage biology correlate with susceptibility to L. donovani infection www.biorxiv.org/content/10.1101/2025.08.01.668127v1
New preprint:
nxReLo: a simple assay to probe direct interactions between nuclear proteins in cells.
www.biorxiv.org/content/10.1...
Joint effort between Sherif, Jana, and Maria, and in collaboration with Peter Andersen @germline.bsky.social.
Beyond the transcript: chromatin implications in trans-splicing in Trypanosomatids www.biorxiv.org/content/10.1101/2025.07.08.663533v1
High-precision cytosine base editors by evolving nucleic-acid-recognition hotspots in deaminase - @uchichemistry.bsky.social bit.ly/46yTSaT
I used inducible CRISPR/Cas9 to make Trypanosoma brucei cell line that allowed me to edit originally muti-copy histone gene. We uncovered a novel role of H4 histone tail in gene regulation. I enjoyed working on this exciting project with @joanarcf.bsky.social, a great mentor.
doi.org/10.1038/s414...
www.nature.com/articles/s41...
Nice to have been involved in this great study from the Horn Lab, driven by @marketanovotna.bsky.social ! Elegant application of CRISPR precision editing and saturation mutagenesis!
We're highlighting some of the best #parasitology papers we've published in the last 5 years. Check out this special collection.
#protistsonsky
onlinelibrary.wiley.com/doi/toc/10.1...
Mitochondrial RNAs can be found in mitochondrial RNA granules (MRGs) where they are processed. However, here the authors show that during transcription arrest, mt-mRNAs form granules distinct from MRGs.
@stirlingchurchman.bsky.social
www.life-science-alliance.org/content/8/9/...
📢 A well-written title and abstract can be the difference between “just another paper” and a highly cited one.
FASEB Publications has a new guide for authors with tips to write titles and abstracts that work harder for your research.
🔗 buff.ly/iODNZww
‼️Update! Abstract submission is now open for the 2025 Liverpool UK @microbiologysociety.org meeting on "Understanding and predicting microbial evolutionary dynamics”! Deadline July 7th #microsky 🧪🧫🦠 microbiologysociety.org/event/societ...
Registration is open for the Microbial Genomics of Eukaryotes meeting in Glasgow! This event will showcase diverse scientific achievements in eukaryotic genome research. Register now and submit your abstract by 12 August: microb.io/MicroGenomic...