Targeting Lysosomal pH Restores Mitochondrial Quality Control in GBA1-Mutant Parkinson’s Disease Heterozygous mutations in the Glucocerebrosidase gene ( GBA1 ), encoding the lysosomal hydrolase β-glucocerebrosidase (GCase), are a genetic risk factor for Parkinson’s disease (PD). To explore the pa...

www.biorxiv.org/content/10.1...
Latest preprint from our lab with some beautiful cell biology 🔬

Redox-dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells When probed using fluorescence lifetime imaging microscopy (FLIM), the emission from reduced nicotinamide adenine dinucleotide (NADH) and its phosphorylated form NADPH have shown promise as sensitive ...

www.biorxiv.org/content/10.1...

the ‘right’ balance…🤔
(Yanai & Lercher, 2025)

Pathogenic variants in autophagy-tethering factor EPG5 drive neurodegeneration through mitochondrial dysfunction and innate immune activation The autophagy-tethering factor, ectopic P-granule 5 autophagy protein (EPG5), plays a key role in autophagosome-lysosome fusion. Impaired autophagy associated with pathogenic variants in EPG5 cause a ...

Our latest preprint!