NREM Oscillations Mediate Synaptic Proteome Remodelling to Support Synapse Stabilisation www.biorxiv.org/content/10.64898/2026.04...

Dorsoventral hippocampus neural assemblies reactivate during sleep following an aversive experience - Nature Neuroscience Synchronization of sharp-wave ripples across the dorsoventral hippocampus during sleep supports coordinated reactivation that represents negative experiences more faithfully than positive ones.

Dorsoventral hippocampus neural assemblies reactivate during sleep following an aversive experience by @ggirardeau.bsky.social and team www.nature.com/articles/s41...

🔔PREPRINT: Sleep ripples drive single-neuron reactivation for human memory consolidation
1/9: How does sleep support human memory consolidation? To test this, we recorded hundreds of neurons in the human medial temporal lobe (MTL) across learning, wakefulness, and sleep.
doi.org/10.64898/202...

Graphical abstract showing that NMDAR immunisation drives psychosis-like behaviour in mice, while clozapine reverses this. Upper panel: arrows show NMDAR immunisation producing a mouse exhibiting psychosis-like behaviour, with clozapine reversing this effect. Lower panels: anti-NMDAR antibodies bind neuronal NMDA receptors, which are then eliminated by microglia via phagocytosis, leading to psychosis. Clozapine restores NMDA receptor levels by reducing anti-NMDAR antibody levels, consistent with an immunomodulatory mechanism of action.

🥁🎉The Psychosis Collective proudly presents our first preprint

𝐂𝐥𝐨𝐳𝐚𝐩𝐢𝐧𝐞 𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐞𝐬 𝐚𝐮𝐭𝐨𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐝𝐫𝐢𝐯𝐢𝐧𝐠 𝐩𝐬𝐲𝐜𝐡𝐨𝐬𝐢𝐬-𝐥𝐢𝐤𝐞 𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐮𝐫 𝐢𝐧 𝐦𝐢𝐜𝐞

𝘈 𝘥𝘪𝘴𝘤𝘰𝘷𝘦𝘳𝘺 𝘫𝘰𝘶𝘳𝘯𝘦𝘺 𝘪𝘯 𝘵𝘩𝘳𝘦𝘦 𝘢𝘤𝘵𝘴

starring Le He & Harriet Feldman

www.biorxiv.org/content/10.6...

We wanted to understand how antipsychotics work. Thread🧵

🧠💤 New paper out in @plosbiology.org! Together with Adriana Michalak (@dr-adri.bsky.social), Davide Marzoli, Francesco Pietrogiacomi et al., we show that dreaming, especially immersive dreaming, plays a key role in how deep sleep feels.

🔗 doi.org/10.1371/jour...

@erc.europa.eu #ERC-StG #sleep

Deconstruction of a memory engram reveals distinct ensembles recruited at learning - Nature Neuroscience Pouget et al. identified distinct CA1 neuron ensembles active during specific moments of fear learning and uncovered the core engram essential for memory formation.

How does the brain build a memory?
A common assumption is that the neurons activated during an experience collectively form the memory engram.
In our new Nature Neuroscience paper (finally out!), we show that this is not the case.
www.nature.com/articles/s41...

Every time you experience something new, your brain faces a decision: Should it update an existing memory or create a new one?

In our new paper in @sfnjournals.bsky.social #JNeurosci, we isolate that exact decision, moment-by-moment during learning 🧵

Young PI Symposium 2026 Visit the post for more.

Today we present another of our amazing speakers: @anne-schreiter.bsky.social the executive director from @gso-forresearchers.bsky.social. She will give us an interactive workshop about Leadership and Team-building.

Register to our @fens.org Satellite 👉 youngpisymposium2026.com

The deadline for our young PI symposium was extended! Don't miss out on this opportunity to build your community and share strategies to navigate these uncertain times.

Human hippocampal theta–gamma coupling coordinates sequential planning during navigation

Impressive study from Dan Bush's Lab at UCL:

www.pnas.org/doi/10.1073/...

Registration open 🎉

MEEP – Heidelberg Summer School on Memory and Sleep

www.zi-mannheim.de/forschung/ab...

Awesome new opportunity to join SWC if you are into human ephys.

Do you work or study in the fields of psychology, neuroscience, computer science, artificial intelligence, or philosophy?

What does the term 'representation' mean to you?

We invite you to participate in a brief survey on key conceptual questions across fields.

eu.surveymonkey.com/r/VX9GNXM

Building compositional tasks with shared neural subspaces Nature - The brain can flexibly perform multiple tasks by compositionally combining task-relevant neural representations.

Thrilled that my paper is out in the @nature.com. We explored how the brain builds complex tasks by compositionally combining simpler sub-task representations. The brain flexibly performs multiple tasks by dynamically reusing neural subspaces for sensory inputs and motor actions

rdcu.be/eRVUk

New paper alert! 🚨

We found that the brain's compass is remarkably stable at two scales

1️⃣ the system maintains its internal organization for weeks
2️⃣ It "remembers" its orientation for weeks, even after a single visit

This may be key to how the brain aligns its other maps.

Paper: rdcu.be/e3waP

Can we make brains “smarter”? By boosting mitochondrial metabolism in neurons of memory circuits, we improved memory in flies and mice. Thrilled to see this work out - congrats to @amrapalianjali.bsky.social for spectacular work, and to all lab members for invaluable contributions!

Why did consciousness evolve at all? A superb special issue of @royalsocietypublishing.org brings together experts across disciplines to explore the functions of consciousness and why it emerged in some species but not others. @tecumsehfitch.bsky.social royalsocietypublishing.org/rstb/issue/3...

"..hippocampal-prefrontal systems represent emotion concepts in a map-like way at multiple levels of abstraction.."

Map-like representations of emotion knowledge in hippocampal-prefrontal systems
by
@yumengma.bsky.social and @pkragel.bsky.social

www.nature.com/articles/s41...

My lab is looking to recruit 1-2 paid summer interns to do wet lab work on learning in a unicellular organism (Stentor coeruleus). You can apply here:
forms.gle/b47WpSobjFjo...

Many people have no mental imagery. What’s going on in their brains? People with aphantasia are offering a window into consciousness.

Most people can call up pictures in their minds, visualizing the past & summoning images of the future. But for ~4% of us, such mental imagery is weak or absent. New edition of @nature.com has a nice introduction to how research on this phenomenon (aphantasia) opens up novel windows into the brain.🧪

Infraslow modulation of theta synchrony in the hippocampus circuit during REM sleep www.biorxiv.org/content/10.64898/2026.01...

Attention-like regulation of theta sweeps in the brain's spatial navigation circuit www.biorxiv.org/content/10.64898/2026.01...

This is totally wild. Remember the object they are attending to is presented egocentrically, but the allocentric theta sweeps follow it. The whole system is wired up to provide something like an "integrated attention reflex".

Deadline is almost here, have you applied? fenskavlinetwork.org/who-we-are/a...

Sequential coupling of sleep oscillations enables concept-neuron reactivation and supports information flow across the human hippocampal-cortical circuit www.biorxiv.org/content/10.64898/2026.01...

Tolman's Sunburst Maze 80 Years on: A Meta‐Analysis Reveals Poor Replicability and Little Evidence for Shortcutting In 1946, Tolman et al. reported that rats could take a novel shortcut to a goal after training on an indirect route, supporting the Cognitive Map theory. However, a review of subsequent Sunburst maze...

Can humans & animals really use internal maps to take shortcuts?

Tolman famously said yes - based largely on his Sunburst maze.

Our new review & meta-analysis suggests evidence is far weaker than you might think.
🧵👇 doi.org/10.1111/ejn....

@uofgpsychneuro.bsky.social @ejneuroscience.bsky.social

Very happy for this @ejneuroscience.bsky.social editorial on the importance of diverse research animals in neuroscience. We make the case that embracing a plurality of model organisms enriches the field and accelerates both basic and translational research. onlinelibrary.wiley.com/doi/10.1111/...

What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality. www.biorxiv.org/content/10.6...

Meta-learning is expressed through altered prefrontal cortical dynamics www.biorxiv.org/content/10.64898/2026.01...