Getting geared up for OARSI?🤩

Mark your calendars for the OAC/OAC Open Journal Session on April 23rd, 2026 11 am-12:30 pm EST. 🌴

Our #Basic #Science infographic for the month of #April is this work by Sun et al.

This work investigates the role of ac4C modifications in cartilage endplate degradation as a result of excessive compression.

Read more: sciencedirect.com/science/arti...

Unraveling the shared genetic architecture of osteoarthritis and metabolic traits through multi-omics insights Osteoarthritis (OA) often coexists with metabolic traits (MTs), causing significant disability. Our study aims to uncover the shared genetic mechanisms between OA and MTs, revealing novel OA-MT relate...

#Osteoarthritis (OA) often coexists with metabolic traits (MTs), causing significant disability. 🧬

Liao et al. aimed to uncover the shared genetic mechanisms between OA and MTs, revealing novel OA-MT related genes, proteins and pathways.

Read more🔖:
www.oarsijournal.com/article/S106...

Cellular and molecular changes in the human osteoarthritic and aging hip pulvinar Osteoarthritis (OA) is a multifaceted pathology characterized by complex signaling across joint tissues. The sub-synovial adipose tissue (ssAT) has been proposed to function as a stem cell reservoir, ...

You might have heard of the SAT...but have you heard of the ssAT? 🤓
Tilouche et al. investigated the sub-synovial adipose tissue (ssAT), which functions as a stem cell reservoir, mechanosensor, neuroendocrine organ, and inflammatory regulator.

📑: www.oarsijournal.com/article/S106...

🚨Standard scRNA-seq often excludes cells with high mitochondrial RNA content (pMT).🚨

Work by Tran et al. investigates how exclusion of high-pMT cells affects the transcriptional landscape of knee OA synovium and explores their role in disease.

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sciencedirect.com/science/arti...

Chromatin accessibility in MSC chondrogenesis, adult hip cartilage chondrocytes and osteoarthritis Cell type-specific gene expression programs are mediated by interactions between enhancers, transcription factors and gene promoters. Access to the DNA is regulated by the presence and modification st...

New #OMICs work by Barter et al. seeks to reveal the chromatin accessibility of the #cartilage chondrocyte genome and identify changes that occur in accessibility during both development from mesenchymal stem cells (MSC) and in #osteoarthritis (OA).

🔗: www.oarsijournal.com/article/S106...

Transcriptomic profiling confirms microRNA-140 is more functional in joint development than in disease To investigate the distinct roles of microRNA-140 (miR-140) in skeletal development and osteoarthritis (OA), and to identify novel miR-140–5p targets using advanced transcriptomic profiling.

What is the role of microRNA-140 in joint development and in post-traumatic OA? 🧐

Hao et al. sought to investigate this question with spatial transcriptomics in our #OMICS #Special #Issue in #OAC.

Read more to discover their findings:
www.oarsijournal.com/article/S106...

This new paper in #OAC is fire🔥.

The title says it all "From fat to flame...", how does adipose-joint crosstalk stoke the fires of OA?🔥🔥🔥

Check out these multi-omic assessments by Wijesinghe et al.🔥

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www.oarsijournal.com/article/S106...

Have you ever wondered how synovial fibroblasts respond to different types of injury?
Collins et al. used single-cell RNA-sequencing to study the fibroblast responses to different types and duration of joint injury in mice.
Read more📑:
www.oarsijournal.com/article/S106...

Why does a bad night’s sleep make everything hurt more?

On this week's JointAction podcast, @profdavidhunter.bsky.social hosts Prof. Michelle Hall
to explore the cycle between sleep and pain, and offer some practical strategies to help regain both rest and relief.

shows.acast.com/joint-action...

Cross-platform transcriptomic data integration identifies an overactive neuro-immune signature in human osteoarthritis synovium Chronic synovitis is associated with osteoarthritis (OA) pain, but the molecular underpinnings remain unclear. Our objective was to characterize the transcriptional phenotype of OA synovium with a foc...

Check this out! #New work in #OAC #OMICs special issue!

Newton et al. characterized the transcriptional phenotype of OA synovium with a focus on signaling relevant to pain.

www.oarsijournal.com/article/S106...

Borderline acceleration in blood epigenetic age of unclear biological importance in knee osteoarthritis progression: Specimens and data from the Osteoarthritis Initiative and Johnston County Osteoarth... Aging is a strong risk factor for osteoarthritis (OA). Previous studies have not found accelerated blood epigenetic aging in OA patients generally. The goal of this study was to evaluate peripheral bl...

Does epigenetic aging accelerate OA?

This work by Brawner et al. seeks to determine whether systemic epigenetic aging aberrations is associated with the risk of future rapid radiographic and/or pain progression in individuals with knee OA.

🔗 www.oarsijournal.com/article/S106...

Integrative single-cell analysis reveals transcriptional and epigenetic regulatory features of human developmental dysplasia of the hip Developmental dysplasia of the hip (DDH) is a developmental disorder that has long-term chronic pain and limited hip joint mobility. The aim of the current study is to understand the specific chondroc...

The #Special #Issue on #OMICs is now out!

This work by Xu et al. presents their single cell analysis on chondrocyte composition in developmental dysplasia of the hip- a disorder that has long-term chronic pain and limited hip joint mobility.

Read more🔗
www.oarsijournal.com/article/S106...

Our #OMICs #Special #Issue features work by Jachim et al. identifying gene regulatory networks that drive human articular cartilage cell fate and establishing an in vitro model showing promise as a tool to study cartilage development and homeostasis.
🔗: oarsijournal.com/article/S106...

E1K, a disease-modifying drug candidate for knee osteoarthritis, alleviates pain and regenerates cartilage simultaneously by inhibiting TGF-β1-mediated SMAD1/5/9 signaling in osteoarthritis models Transforming growth factor-β1 (TGF-β1) signaling is critical in joint homeostasis and osteoarthritis (OA) pathogenesis. Engedi 1000 (E1K), a novel short peptide, is a selective modulator of TGF-β1-ind...

Have you heard of E1K?

This month in #OAC learn about E1K, a candidate as a disease modifying #OA drug that alleviates pain and regenerates cartilage simultaneously!

Read more from this work by Moon et al.
www.oarsijournal.com/article/S106...

T2 mapping of the articular cartilage as a biomarker for knee osteoarthritis: An analysis of the population-based Rotterdam Study Only few studies have investigated quantitative magnetic resonance imaging (MRI) T2 mapping of knee cartilage in population-based cohorts. Our objective was to evaluate the association between T2 rela...

How does MRI T2 mapping of articular cartilage in the knee serve as a biomarker for #OA?🧐

Harlianto et al. found in a population based cohort that T2 values were associated with BMI.

Read more: www.oarsijournal.com/article/S106...

Journal Publication of the Year Nomination Form Please click the link to complete this form.

OARSI is excited to announce that NOMINATIONS are open for Publication of the Year! 🤩
Research published in OAC and OAC Open since April 2025 are eligible for nomination!!!

Due March 6th!

Nominate here 🔗: form.jotform.com/223553406964157

🤔 Is there a relationship between osteoarthritis (OA)-induced neuroinflammation and neurodegenerative disorders?

👀 Read all about this interesting topic in this review by Prasoon et al - oarsijournal.com/article/S1063-…

Unicompartmental versus bicompartmental joint space width measures: Which reflect whole joint structural damage better? Data from IMI-APPROACH To investigate the associations between whole joint cartilage and meniscal morphology on MRI and radiographic joint space width (JSW) measures and in knee osteoarthritis (KOA), to determine whether bi...

Does #unicompartmental or #bicompartmental joint space width measures reflect whole joint structural damage better?

www.oarsijournal.com/article/S106...

The basic science #EditorsChoice for #Feb is this work by de Roy et al. Learn about the tribological impact of synovial fluid (SF) viscosity and composition during the different stages of #OA!

Read more📚: www.oarsijournal.com/article/S106...

🏳️‍🌈 Sexual orientation and #OA

⏰ Feb's Editor's Choice by Sha et al. investigated the relationship between #sexualorientation and OA risk in LGBTQIA2S+ population

✅ They found a higher risk of OA in bisexual & lesbian women but a lower risk in gay men

oarsijournal.com/article/S106...

This month in #OAC Hyodo et al. assessed the effects of imeglimin, a novel anti-diabetic agent related to metformin, on the development and progression of knee #OA.

Read more 📚: sciencedirect.com/science/arti...

More #Basic #Science in #OAC this work by Simoes et al. develops a #translational strategy inhibiting aggrecanase activity in #OA using TIMP-3.

Learn more 🔗
sciencedirect.com/science/arti...

New in #OAC, Xu et al. investigates parathyroid hormone-related peptide nuclear localization segment (PTHrP-NLS) and parathyroid hormone 1 receptor (PTH1R) signal-dependent rehabilitative effects of CD90+ chondrocytes on degenerative TMJ cartilage.

oarsijournal.com/article/S106...

How do sex differences in the brainstem alter experimental #osteoarthritis ?🧐

Check out this work by Rodrigues et al.

www.sciencedirect.com/science/arti...

Ziemian et al. demonstrates repetitive loading induced protective effects in the joint & attenuated OA progression over time relative to a single bout of loading even when applied at hyperphysiological load magnitudes known to initiate cartilage damage.
Read more🔗
pubmed.ncbi.nlm.nih.gov/40020990/

The January #EditorsChoice #Basic #Science in #OAC is this review by Wallace et al. Learn about the decreased risk of OA in non-industrialized societies.

Read more: www.sciencedirect.com/science/arti...

As we usher in the new year, we also wanted to celebrate the achievements of a giant in the hashtag#osteoarthritis community.

Read more about Frank's legacy and the Frank Beier Graduate Opportunity Scholarship in this month's issue here: www.oarsijournal.com/article/S106...

🔥 New year new issue!

2026's first editors choice is this large (n>500,000) cohort study on the effects of air pollution on osteoarthritis risk

Read more from Chen et al here: oarsijournal.com/article/S106...

#carbonmonoxide #nitrogendioxide #pm10

#New in #OAC Work from Chen et al. found that treadmill #exercise offers protective effects when initiated early after OA onset but may worsen outcomes if delayed.🏃🏃‍♂️🏃‍♀️
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oarsijournal.com/article/S106...