Great to be back in Cambridge for this year's GSN. Some amazing talks and so great to reconnect with colleagues and to make new acquaintances.
#GSN #genomestability #chromatin #DNA

I really enjoyed putting this review together - great teamwork!
Check it out if you’re curious to learn more about the immediate consequences of replication forks encountering DNA secondary structures!

We hope it’s a useful resource for the field of genome replication and stability.

How DNA secondary structures drive replication fork instability DNA secondary structures, such as hairpins, cruciforms, triplexes, G-quadruplexes and iMotifs, are common, dynamic features that replication forks rou…

Our @costerlab.bsky.social review is out!

It’s a great read on the impact of DNA secondary structures on eukaryotic replication fork progression - a totally unbiased opinion, of course!

www.sciencedirect.com/science/arti...

@adityasethi.bsky.social @billiedelpino.bsky.social

Registrations are now open!!

Our new review, looking into the roles of SWI/SNF in the chromatin environment around centromeres, is just out in Open Biology! @kezlane.bsky.social @thedownslab.bsky.social

Contact us to join our group with support of a Juan de la Cierva post-doctoral fellowship (#JDC2025) and delve into the mechanisms that protect genome integrity during replication using advanced genomics and AI-based modelling of replication fork structures! 📢

t.co/lA3HGPYM8w

Typos in the genome: Defining the molecular mechanism of replication slippage Typos in the genome: Defining the molecular mechanism of replication slippage

🧪📣 PhD studentship available! Please repost.

Our lab has a fully funded PhD position, starting Oct 2026.

We provide a supportive environment and top notch facilities, helping you develop into an independent scientist.

Project details: tinyurl.com/CosterPhD

How to apply: tinyurl.com/ApplyICR

DNA2 enables growth by restricting recombination-restarted replication - Nature DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

Biochemical reconstitution of sister chromatid cohesion establishment during DNA replication Genome inheritance during cell divisions relies on replicated sister DNAs being connected by cohesin rings. Minamino et al. reconstitute sister chromatid cohesion establishment during DNA replication using purified budding yeast proteins. The experiments yield molecular insight into more than one way in which sister chromatid cohesion can be built.

Online Now: Biochemical reconstitution of sister chromatid cohesion establishment during DNA replication Online now:

Now out! Led by @susana-sousa.bsky.social and Noa Amin, and thanks to our collaborators in the Harrington @icr.ac.uk and Stucki and Choudhary @jc4-jyoti.bsky.social labs

www.cell.com/cell-reports...

A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells Nature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present...

Checkout our latest research in @natcomms.nature.com
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team

A fantastic week of science (and nature) at the CSHL Eukaryotic DNA Replication & Genome Maintenance meeting ! #cshldnarep

Genome Centre throughout the years! @gdsc-sussex.bsky.social #GDSC #Brighton #ArchiveShot

Thank you, Uli! Really appreciate your support and all the insightful discussions throughout this project!

Thanks Tony! Always a pleasure collaborating with you!

So pleased to see my PhD project published, great work by everyone involved! Together we uncovered how regulation of the BTRR complex is crucial to protect centromeres during mitosis.

Looking forward to the next Helicase Conference! #HelicasesandNucleicAcidBasedMachines #Lisboa2025

Great to be at the Helicase Conference in Lisbon this week! 🧬
#HelicasesandNucleicAcidBasedMachines #CentroDeCongressos #Lisboa2025 #Unwinding @costerlab.bsky.social

New lab member joining is a great excuse to eat out and take a new lab photo 🎉🍜📷