Latent tuberculosis infection screening and treatment outcomes in healthcare workers in Irish hospitals: a multi-centre cohort study - PubMed LTBI prevalence among HCWs in Ireland was lower than international estimates. While treatment initiation was low, completion was high. Treatment initiation varied by site, driven by institutional rath...

pubmed.ncbi.nlm.nih.gov/41972277/

RA and PsA synovial tissue single-cell analysis demonstrates differential fibroblast populations with distinct phenotypes and functional capacities - PubMed RA and PsA possess distinct FLS populations with unique functional and metabolic properties, which may facilitate improved understanding of disease pathogenesis and therapeutic response.

pubmed.ncbi.nlm.nih.gov/41966860/

Transitioning to adult care for patients with IBD: the impact of a structured IBD transition program on service engagement - PubMed Structured transition programs in IBD can improve engagement of patients with IBD services with significantly lower rates of disengagement with IBD services seen in our study. Large prospective studie...

pubmed.ncbi.nlm.nih.gov/41968442/

Impact of two years of treatment with Elexacaftor/Tezacaftor/Ivacaftor on longitudinal changes in structural lung disease in people with Cystic Fibrosis - Results from the RECOVER trial - PubMed Automated analysis of spirometry-controlled chest CT images in people with CF aged 12 years and older showed that the substantial improvements in bronchial wall thickening, mucus plugging and trapped ...

pubmed.ncbi.nlm.nih.gov/41973991/

A case of breathlessness and unexpected antibodies: stating the obvious - PubMed <span><b>A patient developed breathlessness after starting pravastatin, with transient anti-HMGCR positivity and interstitial changes. Statin withdrawal led to full recovery, highlighting the importan...

pubmed.ncbi.nlm.nih.gov/41988089/

Validation of the Southampton Difficulty Scoring System in Robotic Liver Surgery and Development of the International RoboLiver Difficulty Scoring System - PubMed Difficulty factors in RLS partially overlap with LLS but are not directly transferable. The International RoboLiver DSS provides a calibrated, robot-specific tool for preoperative complexity stratific...

pubmed.ncbi.nlm.nih.gov/41989032/

Approach to Inguinal Hernia Repairs: A Retrospective National Cohort Study in the Republic of Ireland - PubMed Despite advances in laparoscopy, open IHR remain the predominant treatment approach in the ROI. Older, more co-morbid patients and those undergoing emergency repairs are far more likely to have an ope...

pubmed.ncbi.nlm.nih.gov/41989135/

Papers authored/co-authored by staff/affiliates of SVHG @svuh.bsky.social

To mark World Liver Day this Sunday, we're highlighting the research and evidence available from the library to support SVHG staff.

Access evidence on:
✔️ General hepatology
✔️ Liver transplantation
✔️ Liver cancer
✔️ Hepatitis

Library website 👉️ library.svhg.ie

#WorldLiverDay #LiverHealth

Repurposing metabolic drugs as anti-inflammatory agents - PubMed Dysregulation of bodyweight systemic metabolism is intrinsically linked to an inflammatory phenotype, with each underpinning the other. Over the past decade, new classes of drug, such as glucagon-like...

pubmed.ncbi.nlm.nih.gov/40813183/

Cis-regulatory and long noncoding RNA alterations in breast cancer - current insights, biomarker utility, and the critical need for functional validation - PubMed Breast cancer's global prevalence underscores a critical need for novel biomarkers to guide treatment and improve patient outcomes. Biomarker discovery historically focused on mutations in protein cod...

pubmed.ncbi.nlm.nih.gov/41230718/

FDG PET in pulmonary sarcoidosis: An update and future aspects - PubMed Pulmonary sarcoidosis is a heterogeneous granulomatous disease with an unpredictable clinical course, in which accurate assessment of disease activity remains a major clinical challenge. Although up t...

pubmed.ncbi.nlm.nih.gov/41936480/

Trends in primary brain tumour incidence and mortality in Ireland 1995-2019 - PubMed Trends in primary brain tumour incidence and mortality in Ireland 1995-2019

pubmed.ncbi.nlm.nih.gov/41945218/

Epidemiology and antimicrobial resistance patterns of Aeromonas species in Europe, 2020-2024 (AEuROMONAS) - PubMed Aeromonas species in Europe showed high susceptibility to ceftazidime and cefepime, alongside with emerging resistance to fluoroquinolones and sulfamethoxazole/trimethoprim. Species-specific findings ...

pubmed.ncbi.nlm.nih.gov/41946308/

Beyond the Scope: A Global Perspective on gender disparity among advanced endoscopists - PubMed Introduction Females remain underrepresented in advanced endoscopy (AE). Factors such as ergonomics, concerns over radiation exposure and traditional family roles have been identified as barriers in p...

pubmed.ncbi.nlm.nih.gov/41946469/

The burden of autoimmune pulmonary alveolar proteinosis: a systematic review - PubMed The results highlight the multifactorial and substantial burden of aPAP on patients. Significant unmet needs remain, particularly in achieving timely and accurate diagnosis and in providing effective,...

pubmed.ncbi.nlm.nih.gov/41951241/

Assessing the quality of consent discussions in intensive care unit research: A scoping review of outcome measures - PubMed We identified a limited, heterogeneous body of literature assessing the quality of informed consent for ICU-based research. This highlights an important gap and an unmet need for the development and v...

pubmed.ncbi.nlm.nih.gov/41955921/

Correction: Ureteral stricture: current treatment algorithm and key surgical principles in the robotic upper urinary tract reconstruction era - PubMed Correction: Ureteral stricture: current treatment algorithm and key surgical principles in the robotic upper urinary tract reconstruction era

pubmed.ncbi.nlm.nih.gov/41963710/

Papers authored/co-authored by staff/affiliates of SVHG @svuh.bsky.social

Meeting time in range and time below range targets is not associated with psychological outcomes in type 1 or insulin-treated type 2 diabetes in the Hypo-METRICS study - PubMed Meeting the composite target of time in range (TIR) >70% and time below range (TBR) <4% was not associated with differences in diabetes distress, fear of hypoglycaemia, depression, or anxiety in participants with type 1 (T1D) or insulin-treated type 2 diabetes (T2D) in the Hypo-METRICS study. …

pubmed.ncbi.nlm.nih.gov/41933840/

Exploring the gap between sensor-detected (SDH) and person-reported hypoglycaemia (PRH): The voice of people living with diabetes - PubMed These results demonstrate that SDH and PRH each capture different, yet equally important, dimensions of the hypoglycaemia experience. Relying on only one source of information inevitably provides an incomplete picture. By integrating the patient's voice, diabetes professionals can provide appropriat …

pubmed.ncbi.nlm.nih.gov/41906206/

Utility of multi-spline multi-electrode 3D mapping catheters in idiopathic outflow ventricular tachycardia - PubMed Utility of multi-spline multi-electrode 3D mapping catheters in idiopathic outflow ventricular tachycardia

pubmed.ncbi.nlm.nih.gov/41915338/

Emergency management of shoulder fracture-dislocation-An assessment of current practice in the Emergency Department of a University Teaching Hospital - PubMed Emergency management of shoulder fracture-dislocation-An assessment of current practice in the Emergency Department of a University Teaching Hospital

pubmed.ncbi.nlm.nih.gov/41915344/

Bimekizumab for treatment of moderate to severe hidradenitis suppurativa: A real-world, single centre case series - PubMed Response rates in this group at week 16 are higher than those seen in phase III clinical trials, despite previous biologic exposure in all patients. While concomitant HS medication may play a role in this higher response rate, bimekizumab is an important treatment option for moderate-to-severe HS.

pubmed.ncbi.nlm.nih.gov/41915783/

Outcomes according to timely or delayed primary percutaneous coronary intervention or fibrinolysis in a national registry of patients with ST-segment elevation myocardial infarction - PubMed A sizeable proportion of STEMI patients continue to receive treatment with delayed primary PCI. This is associated with an increased risk of mortality through 3 years in comparison to fibrinolysis.

pubmed.ncbi.nlm.nih.gov/41916670/

Access to lymphangioleiomyomatosis care across Europe: an ERN-LUNG survey of clinical practice, and the case for a European registry and trial network - PubMed <span><b>A European LAM Registry would enable standardised data collection, support clinical research and facilitate transnational collaboration, establishing an optimal platform for advancing care and developing a coordinated trial network</b> https://bit.ly/4no2xlr.</span>

pubmed.ncbi.nlm.nih.gov/41918953/

Impact of audit and feedback on transurethral resection of bladder tumour quality: a monocentric post-completion evaluation of the RESECT trial - PubMed Participation in a service-wide audit and feedback programme resulted in sustained improvements in TURBT surgical quality indicators after programme completion. This did not yield a detectable reduction in recurrence, highlighting the multifactorial nature of oncological outcomes in non-muscle-invas …

pubmed.ncbi.nlm.nih.gov/41919786/

Tandem RNA and Protein Extraction: A Platform for Maximizing the Use of Limited Ex Vivo Tissue Samples - PubMed Human tissue samples represent the gold standard for obtaining clinically relevant and translatable insight into disease processes that in vitro systems cannot fully reproduce. However, patient-derived samples are often limited in size and availability, limiting the number of downstream assays that …

pubmed.ncbi.nlm.nih.gov/41924244/

Effects of Elexacaftor/Tezacaftor/Ivacaftor on cough frequency, physical activity patterns, and sleep quality in adolescents and adults with cystic fibrosis - PubMed ELX/TEZ/IVA treatment led to a > 90% reduction in daily cough frequency, with sustained improvements in physical activity and better perceptions of sleep quality.

pubmed.ncbi.nlm.nih.gov/41925449/

Reply to: "Letter to the Editor Regarding Abdulla HA, McGarry J, Kaczorowska R, et al. Oncologic Outcomes of Sentinel Lymph Node Biopsy Versus Targeted Axillary Dissection for Node-Positive Breast Cancer Patients After Neoadjuvant Chemotherapy: A Systematic Review and Meta-analysis" by Montagna et al - PubMed Reply to: "Letter to the Editor Regarding Abdulla HA, McGarry J, Kaczorowska R, et al. Oncologic Outcomes of Sentinel Lymph Node Biopsy Versus Targeted Axillary Dissection for Node-Positive Breast Cancer Patients After Neoadjuvant Chemotherapy: A Systematic Review and Meta-analysis" by Montagna et al

pubmed.ncbi.nlm.nih.gov/41933242/