Tomorrow - Join the NIC for the Human HSC Ontogeny webinar with speakers Hanna Mikkola and Elizabeth Ng. View the webinar details and register on www.iseh.org/ISEHWebinars

Please RP.
We are thrilled to announce that our lab’s first preprint is out!
”Whole-genome single-cell multimodal history tracing to reveal cell identity transition”

We report HisTrac-seq, a multiomic single-cell molecular recording platform.
www.biorxiv.org/content/10.1...

Yes, the headline states 'Looks to' because the practice hasn't been adopted widely. But do read beyond the headline — the article describes how a controlled burn in April 2023 protected a region including the airport two months later.

Canada Looks to Centuries-Old Indigenous Use of Fire To Combat Out-of-Control Wildfires https://www.freep.com/videos/news/local/michigan/2024/07/12/canadian-wi… As Canada deals with the same wildfire problems plaguing the western U.S. — fires of increasing...

Cranbrook, BC 2023

pulitzercenter.org/stories/cana...

Not even pub quiz-level expertise.

Multiple TF-coactivators regulate enhancer/promoter activity. Right?
But how can just one histone modification (H3K27ac) distinguish an enhancer from a non-enhancer?
While still a valuable indicator, it is just one component of a complex feature.

Image credit: @gloglita.bsky.social‬ @lifescienceeditors.bsky.social‬ captured DynaTag in action: a pA-Tn5 probe (multicoloured) binds an antibody (white), which binds p53 DNA-binding domain (green) on DNA (blue) within 2 nucleosomes

🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)

Epigenetic priming of mammalian embryonic enhancer elements coordinates developmental gene networks - Genome Biology Background Embryonic development requires the accurate spatiotemporal execution of cell lineage-specific gene expression programs, which are controlled by transcriptional enhancers. Developmental enha...

🚨 New paper alert 🚨
I am excited to share our new work on epigenetic enhancer priming in early mammalian development
genomebiology.biomedcentral.com/articles/10....
Fantastic collaboration with Wolf Reik’s team, with key contributions from many others, led by the excellent Chris Todd.
Short 🧵

Non-canonical enhancers control gene expression and cell fate in human pluripotent stem cells Enhancers are key gene regulatory elements that ensure the precise spatiotemporal execution of developmental gene expression programmes. However recent findings indicate that approaches to identify en...

Delighted & excited to share our latest preprint on non-canonical enhancers in human pluripotent stem cells, the result of a fantastic and fun collaboration with @guenesdoganlab.bsky.social‬:
www.biorxiv.org/content/10.1...

🧵 below

The human proteome with direct physical access to DNA Zero-distance photo-crosslinking reveals direct protein-DNA interactions in living cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale of minutes with single-amino-aci...

Excited our paper is out in Cell @cp-cell.bsky.social!
🧬⚡ DNA photo-crosslinking proteomics in living cells
🎯 Pinpoints protein-DNA interactions to single amino acids
🌎 Globally quantifies DNA binding for >1800 proteins at a timescale of minutes
🔗 www.cell.com/cell/fulltex...
🧵

Delighted to share the latest preprint from the lab led by Janith Seneviratne

We reveal novel roles for #embryonic regulators DPPA2/4 in facilitating a H2AK119Ub primed #chromatin state when aberrantly up-regulated in non-small cell lung #cancers 🧬🔬 (1/6)

www.biorxiv.org/content/10.1...

Voting by mail – Elections Canada Apply to vote by mail, Eligible electors can apply to vote by special ballot. With a special ballot, you can vote by mail from anywhere in the world, 2025.

Canadians 🇨🇦 abroad - you can register to vote in the election! You need to do it soon. www.elections.ca/content2.asp...

ISEH is thrilled to announce the recipients of the 2025 Society Awards, which will be presented at the ISEH 54th Annual Scientific Meeting. Read more about each award recipient on www.simplyblood.org

This is a very important story about our Mob’s Health YouTube video by ANU National Centre for Indigenous Genomics

Welcome to our YouTube channel, 𝗔𝗡𝗨 𝗜𝗻𝗱𝗶𝗴𝗲𝗻𝗼𝘂𝘀 𝗚𝗲𝗻𝗼𝗺𝗶𝗰𝘀. We are delighted to have you join us as we explore the fascinating world of Indigenous genomics research.

Watch the video here: www.youtube.com/watch?v=So6d...

Be sure to subscribe and stay tuned for more insightful content.

New Canada-Australia genomics collaboration to strengthen research impact - GenomeCanada Genome Canada is thrilled to strengthen our long-standing relationship with Australia’s genomics community and our partners at Australian Genomics

As part of the #TeamCanada Trade Mission to Australia, Genome Canada is proud to announce a new collaboration with @ausgenomics.bsky.social to strengthen the impact of genomics technologies for both countries.

Happy International Women & Girls in Science Day 2025

#WomenInScience #womeninSTEM #IDWGS

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

NDP a hard left party?? We truly are through the Overton window now.

CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks Techniques for genome-wide epigenetic profiling have been undergoing accelerated development toward recovery of high-quality data from bulk and single cell samples. DNA-protein interactions have tradi...

📢 CUT&Tag version 3

Sometimes the preprint to paper route can be quite the odyssey. And so in that vein, we are delighted to give you version 3 of our CUT&Tag optimization and benchmarking manuscript:

www.biorxiv.org/content/10.1...

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.

Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this!

So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work!

www.cell.com/molecular-ce...

A ‘Second Tree of Life’ Could Wreak Havoc, Scientists Warn (Gift Article) Research on so-called mirror cells, which defy fundamental properties of living organisms, should be prohibited as too dangerous, biologists said.

Shareable link to @carlzimmer.bsky.social article in NYTimes on serious concerns over mirror bacteria, published in Science today.

www.nytimes.com/2024/12/12/s...

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Tabula Sapiens reveals transcription factor expression, senescence effects, and sex-specific features in cell types from 28 human organs and tissues The Tabula Sapiens is a reference human cell atlas containing single cell transcriptomic data from more than two dozen organs and tissues. Here we report Tabula Sapiens 2.0 which includes data from ni...

Major milestone: Tabula Sapiens 2.0 maps tissue composition & TF expression in 175 cell types, identifying 745 ubiquitous & 890 cell type-specific TFs (many still uncharacterized -> #Codebook) w/ roles in tissue homeostasis, stress response & metabolism. #SingleCell www.biorxiv.org/content/10.1...

The dynamics of hematopoiesis over the human lifespan - Nature Methods This Resource presents an atlas classifying the age-related changes in human hematopoietic stem and progenitor cells from gestation through aging.

Just in time for #ASH24, our latest paper is out. We performed scRNA-seq on HSPCs over human development, maturation, and postnatal aging. We looked at dynamics of HSPC subsets, lineage biases, HSC level priming, and identified a developmentally restricted human HSC.
www.nature.com/articles/s41...

Morphological map of under- and over-expression of genes in human cells Cell Painting images offer valuable insights into the state of a cell and enable many biological applications, but publicly available arrayed datasets only include hundreds of genes perturbed. The JUM...

Now on biorxiv! The JUMP-Cell Painting Consortium’s paper:

“Morphological map of under- and over-expression of genes in human cells”

This is the genetic perturbation portion of the JUMP’s dataset; our chemical perturbation paper will come in a few months
www.biorxiv.org/content/10.1...

To quote @denisduboule.bsky.social , IMHO one of the best definition of curiosity-driven basic research & serendipity

"going off to look for mushrooms and coming back with blueberries. If you are payed to find the mushrooms, you won't come back with the blueberries. You will come back with nothing.

An amazing opportunity to be the Nossal Professor of Immunology @wehi-research.bsky.social An adventure of a lifetime! Bonuses: Vegemite at morning tea and chocolate Tim Tams last Friday of the month. Not a bad place to live either 🌞🏖️ Additional bonus unique 🇦🇺creatures 🦘🐍🕷️🐨

Tiger snakes in the carpool.

Here it is! Congratuations to @jesskelley.bsky.social @edimitrova.bsky.social @neilblackledge.bsky.social @aleksszczurek.bsky.social and the rest of the team (Maciej, Amy, and Hieu). This was a fab collaboration with Arminja Kettenbach. Also see a lovely complementary paper from Fei Chen's group.