Longitudinal Stent Deformation Leading to Very Late Stent Thrombosis After De-Escalation of Dual Antiplatelet Therapy - PubMed Longitudinal Stent Deformation Leading to Very Late Stent Thrombosis After De-Escalation of Dual Antiplatelet Therapy

New publication: Longitudinal Stent Deformation Leading to Very Late Stent Thrombosis After De-Escalation of Dual Antiplatelet Therapy. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41730641/

The thrombectomy in limb ischemia score (TILI-Score): score proposal and results of an interobserver readability survey - PubMed Standardized angiographic endpoints for evaluating treatment success after thrombectomy in acute limb ischemia (ALI) are lacking, limiting comparability across trials and clinical practice. We develop...

New publication: The thrombectomy in limb ischemia score (TILI-Score): score proposal and results of an interobserver readability survey. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41706386/
#CVRCBern

Unveiling a hidden brain barrier - PubMed Unveiling a hidden brain barrier

New publication: Unveiling a hidden brain barrier. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41680325/
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Mechano-electrical feedback in transgenic rabbit models of long QT syndrome Type 2 and short QT syndrome Type 1 - PubMed Mechano-electrical feedback-induced electrical changes, partly mediated by SACs, occur in WT, SQT1, and LQT2, but MEF effects are strongest in LQT2. Mechano-electrical feedback induces pro-arrhythmic ...

New publication: Mechano-electrical feedback in transgenic rabbit models of long QT syndrome Type 2 and short QT syndrome Type 1. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41553502/
#CVRCBern

Join the Swiss Autophagy Conference 2026 (3-4 Sept, Fribourg)!

A dynamic meeting for PhDs, postdocs & early-career researchers to present, learn & connect. Theme: Autophagy in Development, Disease & Ageing.

📝 Abstracts: 21 June
✅ Register: 31 July

buff.ly/sg93Qk6

Left Atrial Appendage Occlusion Versus NOACs in patients With Atrial Fibrillation: Rationale and Design of the CATALYST Trial - PubMed URL https://clinicaltrials.gov; Unique Identifier NCT04226547.

New publication: Left Atrial Appendage Occlusion Versus NOACs in patients With Atrial Fibrillation: Rationale and Design of the CATALYST Trial. Congratulation to the authors!
pubmed.ncbi.nlm.nih.gov/41638386/

Minimum-Radiation Percutaneous Coronary Intervention for Pregnant Woman With Acute Coronary Syndrome - PubMed Intracoronary imaging-guided PCI allows precise and safe treatment in pregnant ACS patients. Drug therapy must be adapted to avoid fetal risk while ensuring maternal protection.

New publication: Minimum-Radiation Percutaneous Coronary Intervention for Pregnant Woman With Acute Coronary Syndrome. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41709805/
#CVRCBern

The gut-heart axis in coronary artery disease: a scoping and narrative review of sex-based microbial and metabolic disparities - PubMed Preliminary studies suggest sex-related differences in gut microbiota composition and metabolite profiles in CAD patients. Integrating mechanistic links from microbial metabolism, genetics, epigenetics, and hormones supports a potential role of the microbiota in sex-dependent disease pathways. Curre …

New publication: The gut–heart axis in coronary artery disease: a scoping and narrative review of sex-based microbial and metabolic disparities. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41618437/
#CVRCBern

The interaction of fibrinolysis and the complement system in patients with acute pulmonary embolism, treated with ultrasound-assisted catheter-directed thrombolysis - PubMed Ultrasound-assisted catheter-directed thrombolysis (USAT) with recombinant tissue-type plasminogen activator (rt-PA) is widely used as a reperfusion approach for acute pulmonary embolism (PE). The fibrinolytic effector protease plasmin is known to be a potent activator of the complement system. The …

New publication: The interaction of fibrinolysis and the complement system in patients with acute pulmonary embolism, treated with ultrasound-assisted catheter-directed thrombolysis. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41612339/
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Invasive Right Anomalous Coronary Arteries Assessment: Intravascular Ultrasound and Adenosine vs Dobutamine Fractional Flow Reserve - PubMed In adults with newly diagnosed R-AAOCA and interarterial and intramural course, one-quarter were hemodynamically relevant. FFR_Adenosine could reliably rule-in, while IVUS-MLA could effectively rule-out relevant R-AAOCA, potentially reducing the need for FFR_Dobutamine testing.

New publication: Invasive Right Anomalous Coronary Arteries Assessment: Intravascular Ultrasound and Adenosine vs Dobutamine Fractional Flow Reserve. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41581388/
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Computer generated illustrations in peer-reviewed research - PubMed Computer generated illustrations in peer-reviewed research

New publication: Computer generated illustrations in peer-reviewed research. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41510642/
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Physician-Modified Endografts in Elective Care: A Report From the REgistry of MOdified Treo Endografts in Europe (REMOTE) - PubMed This multicenter retrospective observational study demonstrated that elective PMEG repair of CAAAs using the Treo device is associated with a high-technical-success rate and a low incidence of clinical complications, supporting the safety and feasibility of this approach in the elective setting.Clin …

New publication: Physician-Modified Endografts in Elective Care: A Report From the REgistry of MOdified Treo Endografts in Europe (REMOTE). Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41504532/
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🚨 Register now for Swiss Physiology Meeting 2026!
📅 Sept 3, 2026 | 📍 HEIA-FR
🎤 Keynotes: Andreas Draguhn & Susanna Zierler
🏆 Young Investigator Award – for PhD & early postdocs. Present your work and win prizes!
Register by May 31. Submit poster abstract outside YIA by June 30.

Impact of left atrial posterior wall isolation using pulsed-field ablation in patients undergoing repeat catheter ablation for atrial fibrillation - PubMed Redo PVI with or without adjunctive PWI is safe and effective, with comparable arrhythmia-free survival. Adjunctive PWI prolongs procedural duration without improving outcomes. Randomized trials are required to clarify its role.

New publication: Impact of left atrial posterior wall isolation using pulsed-field ablation in patients undergoing repeat catheter ablation for atrial fibrillation. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41519351/
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Uncertainty Quantification in Hemodynamic Metrics from 4D Flow MRI with Super-resolution in a Carotid Bifurcation Model - PubMed Super-resolution (SR) with supervised learning has emerged as a viable tool to enhance 4D flow magnetic resonance imaging (4DMR) data post hoc, but its impact on carotid hemodynamic measurements remains unclear. In this study, we quantified uncertainties in a phantom carotid artery model by comparin …

New publication: Uncertainty Quantification in Hemodynamic Metrics from 4D Flow MRI with Super-resolution in a Carotid Bifurcation Model. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41501306/
#CVRCBern

Optimizing Effective Labeling Efficiency in MINFLUX 3D DNA-PAINT Microscopy by Maximizing Marker Detection Probability - PubMed MINFLUX is a powerful single-molecule approach capable of achieving high spatially isotropic resolution in three dimensions. Current implementations collect localizations strictly serially, but criteria for when to terminate acquisition are often unclear. We therefore systematically investigate the …

New publication: Optimizing Effective Labeling Efficiency in MINFLUX 3D DNA-PAINT Microscopy by Maximizing Marker Detection Probability. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41522613/
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LipidLocator: an open source Shiny web application for spatial lipidomics - PubMed The LipidLocator application is freely available as a Docker image on Docker Hub at pratarora/lipidlocator. Installation instructions and code are available at https://github.com/MercaderLabAnatomy/LipidLocator.

New publication: LipidLocator: an open source Shiny web application for spatial lipidomics. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41668704/
#CVRCBern @nadiamercader.bsky.social

Sex Disparities in Elective Valve-Sparing Root Replacement: Evidence From a Multicentre Study - PubMed Only one-fifth of VSRR patients were women, who presented younger with more HTAD and smaller absolute aortic diameters. Despite these differences, long-term outcomes were equivalent, suggesting that sex alone does not determine surgical results. Earlier surgical referral guided by indexed aortic mea …

New publication: Sex Disparities in Elective Valve-Sparing Root Replacement: Evidence From a Multicentre Study. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41604322/
#CVRCBern

Measurement of turbulent kinetic energy with colour Doppler echocardiography and particle tracing velocimetry in an ex-vivo aortic stenosis model - PubMed In this ex-vivo AS model, both TKE measurement methods successfully differentiated severe from non-severe AS. These findings underscore the potential importance of ultrasound colour Doppler echocardiography in estimating energy loss through turbulence, paving the way for the development of a new dia …

New publication: Measurement of turbulent kinetic energy with colour Doppler echocardiography and particle tracing velocimetry in an ex-vivo aortic stenosis model. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41584505/
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Functional architecture of cardiac TF regulatory landscapes in control of mammalian heart development - PubMed Congenital heart disease (CHD), the most common human birth defect, often results from disruptions in gene regulatory networks (GRNs) that control cardiac lineage specification and cell type identity during heart development. A conserved core set of cardiac transcription factors (TFs) orchestrates t …

New publication: Functional architecture of cardiac TF regulatory landscapes in control of mammalian heart development. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41509364/
#CVRCBern @mosterwalder.bsky.social

Percutaneous left atrial appendage closure with concomitant dual-device implantation: a single-center observational study - PubMed In this small cohort of patients with complex multilobed LAA anatomy, concomitant implantation of two Amplatzer devices proved to be a feasible strategy with acceptable short-term safety, although potentially associated with an increased risk of pericarditis.

New publication: Percutaneous left atrial appendage closure with concomitant dual-device implantation: a single-center observational study. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41503611/
#CVRCBern

Future directions in viscoelastic hemostatic assay usage in bleeding patients - PubMed VHAs are valuable tools for bleeding management but remain limited by platform heterogeneity, incomplete assay specificity, and modest predictive accuracy. Future research should focus on assay standardization, dual platelet inhibition in fibrinogen assays, and improved discrimination of coagulation …

New publication: Future directions in viscoelastic hemostatic assay usage in bleeding patients. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41384757/
#CVRCBern

Pole-To-Pole 3D Radial Trajectory Designs Improve Image Quality and Quantitative Parametric Mapping in the Brain and Heart - PubMed Acquiring nearly opposing spokes in 3D radial trajectory designs compensates phase inconsistencies without requiring additional corrections, which improves quantitative imaging and anatomical visualizations.

New publication: Pole-To-Pole 3D Radial Trajectory Designs Improve Image Quality and Quantitative Parametric Mapping in the Brain and Heart. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41486091/
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All-optical diamond heater-thermometer enables versatile and reliable thermal modulation of ion channels at the single-cell level A living cell is a nonequilibrium thermodynamic system where, nevertheless, a notion of local equilibrium exists. This notion applies to all micro- and nanoscale aqueous volumes, each containing a large number of molecules. This allows one to define ...

New publication: All-optical diamond heater-thermometer enables versatile and reliable thermal modulation of ion channels at the single-cell level.
Congratulations to the authors!
pmc.ncbi.nlm.nih.gov/articles/PMC...
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DDR1 Regulates Femoral Arterial Calcification in Lower-Extremity Artery Disease Through NF-Kappa B Activation - PubMed This study identifies DDR1 as a key driver of calcification in LEAD, operating through NF-κB activation and the expression of calcifying proteins. Targeting DDR1 may offer a novel therapeutic approach to prevent MAC in LEAD.

New publication: DDR1 Regulates Femoral Arterial Calcification in Lower-Extremity Artery Disease Through NF-Kappa B Activation. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41399911/
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A comprehensive workflow for CCTA and OCT data fusion with 3D printing validation: advancing patient-specific testing environments for percutaneous coronary intervention devices - PubMed We present a novel workflow to produce high-resolution patient-specific phantoms of coronary arteries.

New publication: A comprehensive workflow for CCTA and OCT data fusion with 3D printing validation: advancing patient-specific testing environments for percutaneous coronary intervention devices. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41430242/
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Real-Time Fluoroscopic Assessment of Underexpansion Predicts Hemodynamic Valve Deterioration Following TAVR With Balloon-Expandable Device - PubMed Underexpansion of balloon-expandable THVs is associated with an increased risk for HVD at mid-term follow-up.

New publication: Real-Time Fluoroscopic Assessment of Underexpansion Predicts Hemodynamic Valve Deterioration Following TAVR With Balloon-Expandable Device. Congratulations to the authors!
pubmed.ncbi.nlm.nih.gov/41240026/
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The DBMR is pleased to announce that Prof. Lucio Barile, Institute for Translational Research (IRT), Università Svizzera Italiana (USI), Lugano and Ente Ospedaliero Cantonale (EOC), Bellinzona, Switzerland will have a special lecture at our DBMR Research Conference. tinyurl.com/9w2r8bp7

Last week to apply!
Want to attend meetings & present your work?
LS2 & SCNAT are offering PhD Travel Grants (up to CHF 1400) for conferences between Mar-Sep 2026!
You must present (poster or talk) + be an LS2 member.
🗓️ Apply by March 1, 2026: buff.ly/Pj80DRo...

MINFLUX microscopy resolves subunits of the cardiac ryanodine receptor and its 3D orientation in cells - PubMed The cardiac ryanodine receptor (RyR2) constitutes the molecular basis of the process of calcium-induced calcium release where activation of RyR2s can be locally regenerative. Here, we present purely optical data of RyR2 distribution with sub-molecular resolution by applying 3D MINFLUX microscopy. Us …

New publication: MINFLUX microscopy resolves subunits of the cardiac ryanodine receptor and its 3D orientation in cells. Congratulation to the authors!
pubmed.ncbi.nlm.nih.gov/41423693/
#CVRCBern