Stanford MSTP student Songnan Wang and I wrote a preview on Nan Yan's discovery of the immunotransmitter function of 2-5A in the dsRNA sensing. With two big fields emerging, we draw conceptual comparisons with the immunotransmitter cGAMP in the dsDNA sensing. authors.elsevier.com/a/1kuse3qNrU...

At the AACR IO meeting in LA. Come say hi if you are here.

Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...

Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD.

www.science.org/doi/10.1126/...

What a great piece of news so many years in the making. Congratulations Profs Monjie and Mackall.