Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds on FindAPhD.com PhD Project - Unravelling the mechanisms of action of cardiac myosin modulators in health and heart disease at University of Leeds, listed on FindAPhD.com

3.5 yr funded PhD studentship available in my lab October start. Exploring cardiac myosin modulators with cryoEM and mass spec. Get in touch if interested. Apply before 28th July. www.findaphd.com/phds/project...

Untangling the effects of flexibility and the AWI in cryoEM sample preparation: A case study using KtrA Single particle cryo-electron microscopy (cryoEM) is a powerful tool for elucidating the structures of biological macromolecules without requiring cry…

I’m very happy to share my first paper on the effects of AWI interactions and flexibility on SPA data quality! Thank you to everyone on the team 🤩

www.sciencedirect.com/science/arti...

You can pry my em dashes — one of my favorite punctuation marks and one I often use — from my cold, dead keyboard.

I started on this around 2006 so only taken 20 years! The project itself started over 30 years ago. Great to finally see the elusive structure.

Investigation of lipid-protein interactions within mechanosensitive ion channels at Aston University on FindAPhD.com PhD Project - Investigation of lipid-protein interactions within mechanosensitive ion channels at Aston University, listed on FindAPhD.com

📢 Just over 3 weeks left to apply for a 4-year funded PhD position at @astonaime.bsky.social for October 2025. Come study protein-lipid interactions in mechanosensitive channels with me, Dr. Alice Rothnie, and Prof. Corinne Spickett 📢

📅 Application deadline: 7th April 2025

tinyurl.com/4arujyaw

Investigation of lipid-protein interactions within mechanosensitive ion channels at Aston University on FindAPhD.com PhD Project - Investigation of lipid-protein interactions within mechanosensitive ion channels at Aston University, listed on FindAPhD.com

📢 4-year funded PhD opportunity at the Aston Institute for Membrane Excellence, starting in October 2025. The project will focus on studying protein-lipid interactions in mechanosensitive channels📢

📅 Application deadline: 7th April 2025

@astonaime.bsky.social

tinyurl.com/4arujyaw

The mechanosensitive channel YbiO has a conductance equivalent to the largest gated-pore Lane et al. demonstrate that the mechanosensitive channel YbiO can achieve conductances equivalent to the largest gated-pore in nature when subjected to membrane tension. Single-channel analysis shows...

Take a look at our new paper! We show that YbiO can achieve a conductance equivalent to MscL, the largest known gated ion channel. We also show the presence of several subconducting states. One state is consistent with a structure we determine using cryoEM.

www.cell.com/structure/fu...

Sophie Hesketh on LinkedIn: #opentowork Hi everyone! I'm actively seeking an academic or industrial position either back in the UK/Europe, or outside of the government in the US. I have strong…

Hi Folks!
I'm actively seeking a new position, either in the UK/Europe or outside of the government in the US.
Please share with whomever and pass the word along! 🙏
www.linkedin.com/posts/hesket...

New job, new social media. I recently became a lecturer in Biosciences at Aston. I'm incredibly lucky to be associated with @astonaime.bsky.social and am looking forward to many new membrane protein adventures as I set up my lab for the first time.

Preprint is up! www.biorxiv.org/content/10.1... Trevor Docter + Ben Sorum found cannabinoids inhibit mechanosensitive K+ channels, including TRAAK mutants that cause epilepsy and FHEIG in humans. #ephys and #cryoem shows CBD competes with lipids to bind inside the channel cavity and block the pore.

Please share, we have #PhD opportunities for anyone interested in filming the #Biophysics of life at the nanoscale.

Full details at: heath-afm-lab.github.io/positions/

Projects based around developing and applying High-Speed Atomic Force Microscopy methods to understand molecular dynamics.