Monthly median Received to Accepted time (days) at Nature Genetics

The GPMap, currently under review at Nature, provides a launching point into scientific questions around the nature of pleiotropy, drug targets / discovery, and instrumental variable selection. Please try it and share!

Funded by @bristolbrc.bsky.social and @imsepidemiology.bsky.social

The Genotype-Phenotype Map A comprehensive map of genetic associations, colocalizations, and rare variant analysis across thousands of traits and molecular measurements.

Excited to announce the release of The Human Genotype-Phenotype Map!

* We processed 16k complex traits & 2.7M QTLs
* Turned 49.3M significant colocalizations into 97k distinct groups
* Upload your own GWAS to compare against all data

Website: gpmap.opengwas.io
Preprint: tinyurl.com/3ktsr9hw

Genetic inference of on-target and off-target side-effects of antipsychotic medications Author summary Many people stop taking antipsychotic medications, not because they don’t work, but because of their side-effects. However, it’s often unclear whether these side-effects are truly cause...

Hello, First post! I have recently got a paper published, we were able to gain insights into the side-effects of anti-psychotic medications using genetic and drug binding data

What's extra interesting is how we are able to infer which receptor the side-effects work through

doi.org/10.1371/jour...

If you think about it with confidence intervals in mind, it could look like this:

3%: [———————o———]———
5%: ——[—————o-—]-————
7% -———[————o-]-—————
0%: -————[——]-o——————