My patient would rather take a peptide than a statin. That reveals an uncomfortable truth in medicine “The volume of evidence behind a therapy has become inversely correlated with public trust in it,” writes Vikas Patel.

“My patient is refusing a drug studied in 170,000 people because of side effects that a 124,000-person analysis just confirmed do not exist — while injecting a compound studied in 14 humans, from unregulated sources, based on the recommendation of someone who profits from selling it.”

I Wrote Research Funding Announcements for NIH for 22 Years. This Year They’ve Published 14 How NIH went from 756 funding announcements to 14 in two years — and what it means for every disease that depends on federal research

open.substack.com/pub/elizabet...
Another thoughtful article from Elizabeth Ginexi on the dramatic reduction in the Notice of Funding Opportunities (NOFO) published by the NIH in 2025 and 2026.

(E.g., I could imagine using opto-DA to match DA amplitudes / avoid the water-restriction regime where the mice probably find the waiting period betw trials to be somewhat aversive)

Lovely work! Do you all know or have a guess about the extent to which the differences in DA amplitudes (eg Fig 2C, ~4% vs. ~15% cue-evoked df/f on day 8) are driving the diff in learning rate, vs. the delay per se?

I like the idea of something like the seafood or egg recommendations you see in grocery stores: www.seafoodwatch.org/recommendati.... Maybe with ratings being a combination of author-dependent, formal review-dependent, and open-source factors.

Enjoying this thoroughly

Ohh the Stabat Mater — can’t say I knew that one had an organ either, but I thought you meant New World :)

There’s an organ in that piece??

Shame that the video gets de-sync’d by the end of it — I see that a lot in these old recordings on YouTube, makes me want to download them and fix em.

My YouTube app has a glitch where the section titles are from the last video I watched…so the exposition was “infusing the ice cream base” (with cedar bark), development “smoke infuser”, adagio “cedar smoked chocolate”, and the finale “tasting the ice cream”. Fitting for a delicious symphony!

The Bluebird Charles Villiers Stanford, The Choral Project · One is the All · Song · 2006

“The Bluebird” by Stanford is a great one: open.spotify.com/track/2RxLbH...

Agreed!

I know this is partly in jest, but the takeaway from the first paper here (and plenty of others like it) is that theta and breathing rhythms co-exist. Most LFP’s aren’t “just” related to breathing :)
www.nature.com/articles/s41...