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Prospective study (Ukraine/Moldova/Spain, n=287): mfloDx™ MDR-TB assay achieved Se 100% / Sp 98.7% for INH+RIF resistance vs culture DST. Caveat: 35% inconclusive results. Potential role as rapid screening tool.
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Does EV-D68 amplify TB immunopathology?
Case series suggests coinfection may worsen lung inflammation, with clinical response seen after corticosteroid escalation.
A reminder to consider viral triggers in atypical TB courses.
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Arboviruses don’t act in isolation 🦟 Chikungunya and Zika spread where structural vulnerabilities persist—limited surveillance, inequity, and inadequate sanitation. Future resilience depends on integrating social and biological surveillance systems 🧬.
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Clinical impact of microbial cell-free DNA next-generation sequencing for invasive mold infection—a single-center retrospective observational study - Rebecca Berger, Nina Howard, Sarah Grant, Fernando... Background: Diagnosing invasive mold infections (IMI) is challenging because they typically occur as opportunistic infections in immunocompromised patients who ...

Diagnosing invasive mold infections 🧫 in immunocompromised patients remains difficult.NGS 🧬 offers noninvasive, actionable insights-identifying missed infections and guiding therapy in over half of cases.
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Malaria 🦟 + soil-transmitted helminths 🪱 often co-infect young children in Nigeria, driving early red cell changes 🩸 before overt anaemia. Host factors esp haemoglobin genotype 🧬matter more than parasite load. journals.sagepub.com/doi/10.1177/...

A systematic review and meta-analysis of hepatitis B virus drug resistance and escape mutations in low- and middle-income countries - Esther M. E. Asamoah, Anastasia A. Asantewaa, Samuel N.-A. Yartey,... Background: Hepatitis B virus (HBV) remains highly endemic in many low- and middle-income countries (LMICs), where challenges such as antiviral resistance and i...

New meta-analysis 📊: HBV escape mutations are common in LMICs
🧬 Immune escape ~56%
💊 Resistance highest with 3TC/LdT
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Successful use of isavuconazole as secondary prophylaxis of cryptococcal meningitis in a person living with HIV and AIDS: a case report - Carmela Pinnetti, Alessandro Giacinta, Federico Cecilia, Franc... Cryptococcal meningitis (CM) is a severe opportunistic infection in people living with HIV (PLWH). We report a 54-year-old man with advanced HIV infection who p...

Case report: in HIV patient with recurrent Cryptocccal meningitis 🧠 despite virologic suppression, re-induction + isavuconazole led to immune recovery, viral control, and no further CM episodes over 6 months
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Chronic pulmonary aspergillosis + pulmonary embolism = a challenging duo 🫁🦠🩸Mechanisms may include inflammation + endothelial damage 🧬Management is tricky—anticoagulation vs hemoptysis risk ⚖️journals.sagepub.com/doi/full/10.1177/2049936...

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P: Mild COVID-19 pneumonia 🦠
I: Clarithromycin 800 mg/day 💊
C: Standard of care
O: No significant change in time to 50% symptom improvement, but ↓ fatigue and ↓ inflammatory cytokines. Signals of immunomodulation worth further study. 🔬
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Contingency management isn’t just for abstinence.A harm-reduction clinic for people who use drugs used incentives to encourage risk assessment, testing, clinic engagement to reduce HIV and infection risk.Early results show engagement among patients. journals.sagepub.com/doi/full/10....

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In a survey of women in 🇿🇦 younger women& those engaged in transactional sex were more likely to intend to use PrEP, while condom users were less likely. #HIVPrevention #PrEP journals.sagepub.com/doi/full/10....

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Strongyloides hyperinfection can occur without eosinophilia—even with CD4 >500 and undetectable HIV viral load. Early diagnosis is lifesaving ⚠️
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Invasive pulmonary aspergillosis remains a lethal threat in immunocompromised and post-COVID patients 🦠 Advances in PCR, lateral flow assays, and immuno-PET/MRI are reshaping diagnosis, but rising azole resistance demands susceptibility testing
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In this systematic review (29 studies), mNGS outperformed culture for spinal infections with broader pathogen detection,higher sensitivity,faster turnaround⏱️ Challenges remain: cost & distinguishing colonization from infection.
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Peptide-based vaccines are redefining precision immunology, offering safety, specificity,scalable manufacturing. This review explores how bioinformatics-driven epitope design, nanoparticles,& next-gen adjuvants are fighting viral threats 🚀🦠
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Ticks strike twice 🐜🐜 Fatal Babesia microti/Borrelia burgdorferi coinfection presenting as acute liver failure and shock. Read full case @
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🦠 Rare but severe: necrotizing gingival & sinus infection due to Trichoderma longibrachiatum in an allo-HSCT recipient. Cure achieved with aggressive surgery 🔪 + combination antifungals 💊, including consolidation with rezafungin.
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Towards personalised empirical antibiotic therapy in febrile neutropenia: a theoretical model based on machine learning and prior colonisation with multidrug-resistant gram-negative bacilli – a retros... Background: Empirical antibiotic therapy (EAT) in febrile neutropenia (FN) remains challenging due to multidrug-resistant (MDR) Gram-negative bacteria, often le...

Febrile neutropenia still drives heavy carbapenem use due to MDR Gram-negatives. In a cohort of 553 FN episodes, an ML risk model + prior colonisation data could cut meropenem use by ~30% and IEAT from 23% to 9%, supporting personalised EAT.
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Chronic pulmonary aspergillosis can complicate pulmonary echinococcosis via residual lung cavities. In this review (41 studies, 72 CPA cases), diagnosis relied on radiology/histology, combined surgical–medical therapy led to uniformly favorable outcomes
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⚠️ Rising MDR in cUTIs demands new options. Plazomicin shows strong in-vitro activity, synergy with key agents, and favorable outcomes in trials—yet real-world evidence from LMICs is urgently needed 📉📊.
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Imidazolopiperazines (KAF156/ganaplacide) show potent activity across blood, liver, and gametocyte stages of Plasmodium 🦟💊—a promising path forward as antimalarial resistance rises.
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Micrococcus luteus-induced prosthetic valve infective endocarditis in an immunocompetent patient: a case report from India - Ritvik Sajan, Sreekrishnan Trikkur Parasuraman, Akhil Arun, 2025 Micrococcus luteus (M. luteus) is a Gram-positive microorganism that typically dwells in environments such as soil, water, and human skin, hence, entitling it a...

🧬 Unusual infection: M. luteus, normally a skin commensal, triggered prosthetic valve endocarditis in an immunocompetent woman. 8 weeks of IV vancomycin led to full recovery.
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📊 New study from Teso, Uganda: Among 1009 TB patients, overall treatment success was 91.9%. Females had higher success, while age >49 and HIV infection lowered success. Early screening, preventive therapy, and peer support are key to improving outcomes.
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Antipseudomonal beta lactams yielded outcomes similar to cefazolin/oxacillin in this study of of MSSA bacteremia.However there were more complicated infections in the SOC arm.These data may inform antibiotic choices when broad coverage is needed.
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Proceedings from Group B Strep in Pregnancy & Babies Conference, Wednesday, May 14th 2025, virtual meeting, 2025

Check out highlights from the 2025 Group B Strep in Pregnancy & Babies Conference: new data spanning antimicrobial stewardship, epidemiology, diagnostics, prevention policies, virulence profiling, and next-gen sequencing for neonatal GBS.
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AI-driven models are showing clear promise in improving HIV/TB detection and management in Nigeria, where immunosuppression drives disproportionate TB risk. Strengthening technical capacity will be essential for translating this potential into practice.
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Data from 89 patients suggest that follow-up FDG-PET/CT can guide decisions in focal infections but is most informative when bacteremia is gram-positive or clinical status deteriorates. Findings support targeted rather than routine use. 🔍🦠📊 journals.sagepub.com/doi/full/10....

Recurrent UTIs remain a major burden, and new guidance is steering care toward non-antibiotic prevention—behavioural measures, topical oestrogen, methenamine hippurate, and intravesical HA/CS 💡💊💧
Read this review for more 📘✨
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Antibiotics disrupt gut/airway microbiomes across ages 🦠, amplifying both targeted and background resistance genes 🧬. Recovery remains especially poor in children 👶
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Impact of a multistep urinary tract infection-focused disease state stewardship initiative on the treatment of asymptomatic urinary presentations: a retrospective cohort study - Christian Tyler Pitcoc... Background: Asymptomatic bacteriuria (ASB) is often overtreated, risking patient harm through unnecessary antimicrobial use and fostering antimicrobial resistan...

A multistep UTI-focused stewardship initiative reduced unnecessary treatment of asymptomatic presentations by 12% & improved adherence to UTI management guidelines.
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