Hi! We find that replacement of endogenous integrin beta1 with a non-phosphorylatable mutant, reduces cancer invasion, and this was phenocopied by Shp2 inhibition in WT expressing cells (not in the mutant cells). It may be that Src & paxillin phosphorylation is also reduced in the mutant cells.

New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...

Ready to share our work as a poster at the upcoming Lorne Cancer Conference! Looking forward to discussing the role of integrin β1 in cancer invasion, and connecting with experts in the field. #LorneCancer2025