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Posts by Pierre Bourguet

Interesting changes to ERC eligibility, low scores now exclude you from reapplications for up to 3 years.

4 days ago 5 3 0 0

📣📣 Deadline approaching 📣📣 (Please re-post)

If you are thinking of starting (or moving) your lab, do not miss the opportunity to apply to join us at the
@i2bcparissaclay.bsky.social

Diversity of topics, interdisciplinary environment and excellent platform support! Recommended!

1 week ago 9 12 0 0
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Emerging roles of lipids in nuclear function and homeostasis Summary: Lipids are increasingly recognized as essential regulators of nuclear homeostasis, membrane dynamics, mechanotransduction and genome stability, opening new frontiers for understanding nuclear...

Beyond proteins and DNA, #lipids are emerging as key players in nuclear biology - shaping nuclear envelope dynamics, mechanosensing, gene regulation and genome stability.

Our new Perspective highlights recent advances, open questions, and future directions 👉 journals.biologists.com/jcs/article/...

1 week ago 26 16 1 0
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Chers Collègues et Amis de Strasbourg, je serai à la Bibliothèque Nationale et Universitaire (BNU) le 21 avril à 18h30 pour partager mes souvenirs d’embryon. Apportez les vôtres! Consultation gratuite.

1 week ago 6 4 0 0
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Can someone please help with the identification of these two #hornwort species found by @noodlyscientist.bsky.social outside OIST/Okinawa/Onna-son/Japan

1 week ago 8 5 3 0
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🧵“What cutoff should I use for p-value, log2FC, or mito content?”

This is the most common question I get.

Here's why it’s not simple:

1 week ago 4 1 1 0

Our work on chromatin evolution in brown algae is finally out!

This is also my first "co-first author" paper!! I’m excited to share what we found 👇

3 weeks ago 55 20 3 1
Fig. 1 (shortened, full legend in paper): Generation of transgenic Arabidopsis for identification of HIT4-interacting proteins using TurboID proximity labeling and MS. (A) Schematic diagram of the constructs used to generate transgenic Arabidopsis lines for TurboID labeling. The experimental construct contains a FLAG-TurboID-HIT4 fusion under control of the native HIT4 promoter, followed by a NOS terminator. The control construct contains a FLAG-TurboID fusion driven by the CaMV 35S promoter with a NOS terminator. (B) Western blot confirming the expression of FLAG-TurboID in both F-TbID/hit4-1 and F-TbID-HIT4/hit4-1 lines, whereas FLAG-TurboID-HIT4 was only detected in F-TbID-HIT4/hit4-1 plants. Rubisco large subunit (Rubisco LS) stained with Coomassie Brilliant Blue (CBB) served as a loading control. Uncropped blots are shown in Supplementary Fig. S1. (C) Complementation analysis of transgenic lines.

Fig. 1 (shortened, full legend in paper): Generation of transgenic Arabidopsis for identification of HIT4-interacting proteins using TurboID proximity labeling and MS. (A) Schematic diagram of the constructs used to generate transgenic Arabidopsis lines for TurboID labeling. The experimental construct contains a FLAG-TurboID-HIT4 fusion under control of the native HIT4 promoter, followed by a NOS terminator. The control construct contains a FLAG-TurboID fusion driven by the CaMV 35S promoter with a NOS terminator. (B) Western blot confirming the expression of FLAG-TurboID in both F-TbID/hit4-1 and F-TbID-HIT4/hit4-1 lines, whereas FLAG-TurboID-HIT4 was only detected in F-TbID-HIT4/hit4-1 plants. Rubisco large subunit (Rubisco LS) stained with Coomassie Brilliant Blue (CBB) served as a loading control. Uncropped blots are shown in Supplementary Fig. S1. (C) Complementation analysis of transgenic lines.

🌡️🧬 RESEARCH 🧬🌡️

Arabidopsis plants use a heat-responsive protein pair, HIT4 and PUB49, to loosen tightly packed DNA, helping them survive high temperatures through a newly discovered stress adaptation mechanism – Wu et al.

🔗 doi.org/10.1093/jxb/...
#PlantScience 🧪

3 weeks ago 15 4 0 0
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Ever wondered how the #cuticle, a hallmark of land plants, was established?

In our latest study, we show that the CUTIN SYNTHASE enzyme family was a key driver of this evolutionary innovation. #plantscience

▶️ www.biorxiv.org/content/10.6...

A thread 🧵 [1/8]

3 weeks ago 88 39 4 1
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🌱🧬 EPIPLANT 2026 is happening soon!

Registration for the conference is still open, but places are limited and filling up fast.

If you haven’t registered yet, now is the time to secure your spot 👉 epiplant-2026.sciencesconf.org

We look forward to welcoming you to Nantes!

3 weeks ago 9 6 0 0
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The fact that Americans thought Auxin was a “Hoax from Europe” rightfully got some attention in my latest #PlantScienceClassics post. But it’s actually even funnier if you learn about the context & consequence of White speaking these words to Went at the AAAS Meeting in Pittsburgh. #PlantScience 🧪
🧵

3 weeks ago 38 27 2 3
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ChromSMF preprint is out!🚀
tinyurl.com/ChromSMF

We often piece together chromatin regulation layer by layer from separate assays. But this can be limiting!

In @arnaudkr.bsky.social's lab, we developed a method to directly study multiple layers on the same DNA molecule! 🧬

What does this unlock? ⬇️

4 weeks ago 111 50 3 2
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You asked, we listened. Millions of AI-predicted protein complex structures are now available in the #AlphaFold Database.

This spans homodimers from 20 of the most studied species, including humans, as well as the World Health Organization’s priority pathogens list.

www.ebi.ac.uk/about/news/t...

1 month ago 157 86 7 4
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Transcript diversity reflects deleterious RNA processing errors shaped by population size in metazoans Alternative transcription initiation, splicing and polyadenylation generate extensive transcript diversity in eukaryotes, but its evolutionary significance has been disputed. This study analyses 166 t...

Back in the noughties when I was an academic, my lab did quite a bit of work on (conserved) alternative transcripts. This study in @plosbiology.org presents compelling evidence that most alternative transcripts are deleterious noise journals.plos.org/plosbiology/...

4 weeks ago 48 28 1 1
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Local agricultural transition, crisis and migration in the Southern Andes - Nature In the Uspallata Valley, agriculture was adopted by local populations, as evidenced by genetic continuity from earlier hunter-gatherers to farmers; maize-dependent groups from the same regional p...

How did farming reach the Southern Andes? Through migration or cultural transmission? Our new paper in @nature.com combines ancient DNA, isotopes, archaeology & paleoclimate to reconstruct 2,000+ years of history in Uspallata, Mendoza.
www.nature.com/articles/s41...
A Thread🧵 (1/25+)

1 month ago 67 32 6 5
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🌳 Do you want to contribute to research on how humans perceive forests? Take this quick, anonymous 10-min survey 🌲

👉 www.biodiful.org#/forest

This will help us explore how people experience forest biodiversity!

Please share on 🦋 & tag @biodiful.bsky.social to reach more participants 🙏💚

🌐🌍🦤🦑🪴🍁🧪

1 month ago 523 620 41 79
As states weaponize supply chains, warnings of deglobalization and aggregate welfare losses have proliferated. But neither has materialized: trade volumes remain high and supply chains continue to span the globe. This paper argues that the surprising resilience of aggregate trade obscures a large-scale redistribution creating K-shaped divergence among firms navigating geoeconomic reordering. Who wins and who loses depends on two dimensions of corporate power: the strategic indispensability of what firms produce and their organizational capacity to reconfigure operations around geopolitical constraints. Because strategic designation attaches to specific outputs rather than broad industry categories, these capacities vary sharply among firms nominally facing identical pressures. Drawing on an original dataset of over 21,000 corporate earnings calls annotated using large language models alongside firm-level financial data, I demonstrate that sector membership explains remarkably little outcome variance. Adaptation operates hierarchically within industries, not between them. Firms controlling chokepoints or possessing reconfiguration capacity capture concentrated gains; those lacking strategic position bear recurring adjustment costs. As these costs cluster in regions previously affected by deindustrialization, supply chain restructuring risks intensifying the geographic polarization that fueled political demand for economic statecraft in the first place.

As states weaponize supply chains, warnings of deglobalization and aggregate welfare losses have proliferated. But neither has materialized: trade volumes remain high and supply chains continue to span the globe. This paper argues that the surprising resilience of aggregate trade obscures a large-scale redistribution creating K-shaped divergence among firms navigating geoeconomic reordering. Who wins and who loses depends on two dimensions of corporate power: the strategic indispensability of what firms produce and their organizational capacity to reconfigure operations around geopolitical constraints. Because strategic designation attaches to specific outputs rather than broad industry categories, these capacities vary sharply among firms nominally facing identical pressures. Drawing on an original dataset of over 21,000 corporate earnings calls annotated using large language models alongside firm-level financial data, I demonstrate that sector membership explains remarkably little outcome variance. Adaptation operates hierarchically within industries, not between them. Firms controlling chokepoints or possessing reconfiguration capacity capture concentrated gains; those lacking strategic position bear recurring adjustment costs. As these costs cluster in regions previously affected by deindustrialization, supply chain restructuring risks intensifying the geographic polarization that fueled political demand for economic statecraft in the first place.

War is reshaping global markets. I have a paper under review that asks: who wins or loses when supply chains meet geopolitics, and what are the political implications?

Since the world is changing faster than our overburdened peer-review system can handle, here's the 📃 + a🧵
osf.io/preprints/so...

1 month ago 14 7 1 0
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Excited to announce I’m starting a new lab at @gmivienna.bsky.social (Vienna BioCentre) in Sept 2026

We study how carbon fixation is inherited and maintained in algae using cryo-ET, imaging, environmental sampling&more

Looking for people who want to build the lab together, get in touch!

#teamtomo

1 month ago 148 47 9 11
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📢 Postdoc position in plant chromatin biology 🌱 (Strasbourg)
Apply before March 30
🔗 www.unistra.fr/fr/recruteme...
#PlantBiology #Postdoc

1 month ago 11 10 0 0
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#JobAlert #PhD 🌱

We are offering a PhD project to explore how transcription factors have shaped the evolution of plant protective barriers.

We will support suitable candidates in applying to the @unistra.fr Graduate School competition.

Interested? Please get in touch for more information!

1 month ago 27 29 0 0
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Open positions - MuSkLE First competitive call open! The first competitive call in the frame of the MuSkLE programme, which aims at selecting 17 doctoral fellows, opens on 6th March 2026 and closes on 6th May 2026. The open ...

📢 PhD position in our lab! (MSCA COFUND)
About dystrophin in Drosophila muscle progenitor cells 🧬🪰
#PhDPosition #DevBio #Drosophila #StemCells
For candidates from outside France or have lived in France <12 months in the last 3 years.
More info 👇 (Project #16)
www.muskle.eu/recruitment/

1 month ago 3 4 0 0
Mechanisms of gene regulation by SRCAP and H2A.Z - Nature Communications SRCAP depletion causes rapid replacement of H2A.Z by H2A, leading to upregulation of lineage-specific transcription factors. SRCAP also prevents pioneer transcription factor binding by steric hindranc...

How do the H2A.Z histone variant and its dedicated chromatin remodeller SRCAP regulate gene expression ?
Beautiful work from @armelletollenaere.bsky.social now published @ www.nature.com/articles/s41...

1 month ago 29 15 2 1
Home | Alyrata Resource

I am happy to announce the launch of a new Arabidopsis genomics resource! Check out arabidopsislyrata.org Now you can easily look at the natural genetic variation across the entire species range of A. lyrata and A. arenosa.

1 month ago 55 35 1 0

➡️ preprint from the lab! Bacteria have loads of antiviral defences in their mobile genetic elements (MGEs). So when MGEs move between bacteria, the defences move with them, generating a fast turnover of defences in bacteria. But what about the antiviral defence turnover in the MGEs themselves? 🤔

🧵👇

1 month ago 76 47 1 3

Exciting work, congratulations !

1 month ago 1 0 0 0

We are very excited to share a new resource from our team: spatial subcellular proteome maps in plants! We developed an MS-based method that registers localizations of about 8000 proteins in Arabidopsis roots in a single experiment.

(1/9)
www.biorxiv.org/cgi/content/...

1 month ago 117 71 2 1
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Einstein

A reminder that we are actively recruiting a geneticist to the Department of Genetics at Albert Einstein College of Medicine

careers-einstein.icims.com/jobs/17847/a...

1 month ago 24 29 1 0
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Another great science appointment is coming up with @centromellone.bsky.social, Michele Pagano and Gergely Róna!
Join us live on Tuesday, March 3rd at 5pm (Rome) / 11am (NYC).
Zoom link: uniroma1.zoom.us/j/95149984403
Register here to stay in the loop: docs.google.com/forms/d/e/1F...

1 month ago 8 5 0 1
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Post-replicative chromatin accessibility predicts cell fate change Knudsen and colleagues use repli-ATAC-seq to compare replicated and unreplicated chromatin in two models of cell identity change. They find that lineage-specific elements are accessible earlier in rep...

DNA replication globally disrupts the epigenome. But does this create a chromatin-access opportunity for TF binding to facilitate cell identity change? Now 𝐫𝐞𝐩𝐥𝐢-𝐀𝐓𝐀𝐂-𝐬𝐞𝐪 shows 𝘥𝘦 𝘯𝘰𝘷𝘰 chromatin opening & TF binding occurs specifically post-replication, in cellular differentiation & reprogramming!

1 month ago 67 26 1 0

Excited to share this work done during my PhD here in Vienna!

We show how chromatin compaction prevents the release of fragmented DNA in apoptosis, and use new tools to study the mechanism of compaction itself.

See our summary/"bluetorial" below & our preprint here: www.biorxiv.org/content/10.6...

1 month ago 28 7 2 0