Takei et al. identified IL-7Rhi CCR6+ Th1-like CD4+ T cells (Th7R) that were distinct from Th1 and Th17 states. Th7R cells expressed CXCL13 and lymphotoxin-β, localized to TLSs, and associated with high endothelial venules. bit.ly/4sBWf47

Figueroa et al. demonstrated that lasting efficacy of adoptive T cell therapy (ACT) against solid tumors relied not only on the antitumor activity of transferred T cells, but also on their ability to expand host CD8+ T cells in a TNF- and cDC1-dependent manner bit.ly/41wROg3

Nie, Liu, Song, and Yao et al. developed a spleen delivery platform of mRNA-loaded lipid nanoparticles (LNPs) covalently bound to erythrocytes (mRNA-LNP-Ery), which naturally target splenic CD11b+ myeloid cells. Unlike conventional LNPs, mRNA-LNP-Ery entered cells via [...] bit.ly/4dKws67

In a model of chronic LCMV infection, surface phosphatidylserine (PS) expression increased in virus-specific PD-1+CD8+ T cells over time, relative to naive CD8+ T cells and the setting of acute infection. PS expression increased with T cell differentiation state. bit.ly/4tbQNpz

Ghosh et al. demonstrated that tissue-resident interstitial macrophages (IMs) and recruited macrophages (recMacs) showed distinct gene expression profiles in B16F10 lung metastases and KPAR1.3 lung tumor models. bit.ly/4tP5M95

Comparing CD4+ T cells generated during acute or chronic hepatitis C virus (HCV) infection, Reinscheid and Weisser et al. evaluated patient samples and found that acute infection generated various subsets of progenitor [...] bit.ly/4syX2Te

Triggering a new source of targetable neoantigens bit.ly/4mt9W3U

Tullia Bruno’s research focuses on tertiary lymphoid structures (TLSs), their formation and function, and whether they can be targeted.
Read more 👉 bit.ly/4viOPp0.

On Demand videos: bit.ly/4sv4Tlu #KSCancerImmune26

Guerriero’s work has focused on characterizing tumor-associated macrophages (TAMs) across breast tumors, where elevated TAM levels are associated with worse outcomes across multiple tumor types.
Read more 👉 bit.ly/4viOPp0.

On Demand videos: bit.ly/4sv4Tlu #KSCancerImmune26

The ACIR team attended the Keystone Symposia on Cancer Immunotherapy: Basic Mechanisms Informing Clinical Application held on March 15-18, 2026 in Quebec, QC, Canada. Read our summary here 👉 bit.ly/4viOPp0.

On Demand videos can be accessed here: bit.ly/4sv4Tlu #KSCancerImmune26

Fu et al. showed that an i.v. or s.c. Tim3-targeted vaccine, generated by conjugating antigens to anti-Tim3 antibodies, delivered antigens to both cDC1s and cDC2s and elicited robust and durable CD8+ T cell responses. bit.ly/4m4OoKD @henryfordhealth.bsky.social

Sun and Xu et al. showed that high expression of the C-type lectin receptor CLEC12B by tumor-infiltrating cells correlated with poor clinical prognosis in patients with HCC. bit.ly/4chwiSu

🚙 A Ju-Jitsu move with an automobile?: A CEA-targeted CAR-T only turned on in the hypoxic TIME doi.org/10.1038/s430...

👉 Tying it all together - a tool to integrate single cell RNA and TCR sequence information across space and time doi.org/10.1038/s414...

🎀 Going after the family name - a DNA vaccine targeting Mammaglobin-A in ERpos breast cancer doi.org/10.1158/2326...

Zhang, Gao, and Hu et al. addressed ways to enhance DC–T cell crosstalk in the TIME. BiDT, a bispecific DC–T cell engager (anti-Tim3–IFNα fusion), simultaneously bound Tim3 on exhausted TILs and activated DCs via the IFNAR receptor. bit.ly/4bZfhex

To improve the potency of a prostate TAA-specific TCR, Chen and Mao et al. screened for CDR hotspot mutations that could increase catch-bond formation and thus TCR sensitivity, without modifying TCR affinity. bit.ly/4m4GzEJ @stanfordmedicine.bsky.social

Using tissue imaging, transcriptional analysis, and machine learning, Fusilier et al. found that immune cell infiltration and localization within established fibrotic tumors could be predicted by the local topography of fibrillar collagens. bit.ly/4ck4YD2 @institutcurie.bsky.social

Using a bilateral, humanized OX40 MC38 tumor model, Liu and Zhao et al. demonstrated that OX40 agonist Ab (agOX40) therapy increased infiltration of NOS2+ pro-inflammatory macrophages and effector CD8+ T cells. bit.ly/3Oax9Lw

Marco et al. sought to expand the utility of immunizing radiation (IR) therapy by intratumorally delivering agents to remodel the tumor immune microenvironment (TIME). bit.ly/4t8ud0W

Cole et al. used HCW9206 – a soluble tissue factor fusion protein that links IL-7, IL-15/IL-15Rα superagonist, and IL-21 – for the generation of T stem cell memory (TSCM)-enriched polyfunctional CAR T cells, without requiring anti-CD3/CD28 activation. bit.ly/4sHTkYv

🤔 To be or not to be: Yes, for Merkel Cell Carcinoma as oncoprotein-specific B cells look highly relevant doi.org/10.1158/2326...

🙌 Self-promotion: Ok, one of us is an author on this excellent review on cancer vaccines doi.org/10.1038/s415...

☠️ Dying is not just for tumors - importance of necroptosis in the stroma doi.org/10.1038/s414...

As an alternative to conventional lipid nanoparticles (LNPs), Zhou, Gao, Huang, and Yan et al. developed a colloid-engineered, LNP-stabilized emulsion (LSE) that was preferentially taken up by APCs [..] bit.ly/3NVRnIR

Zhang et al. identified sialic acid-bearing IgG (SIA-IgG) in PDAC cells, which correlated positively with immunosuppressive (IS) TAM infiltration, and negatively with survival. bit.ly/4sHRmaz

To enhance nanoparticle (NP) uptake by, target gene delivery to, and activation of T cells, Jain et al. generated stable (to lyophilization and freeze/thaw), biodegradable, beta-­amino ester polymer-based NPs with PEG-lipid-­anchored ligands/Abs (tPNPs). bit.ly/4rXoRo6

To address limitations of pancreatic cancer treatment, Ning, Liu, Liu, Zeng, and Qin et al. developed an internalizing, nanobody-based, bispecific ADC (B6ADC) that simultaneously bound TROP2 and c-MET, and was conjugated to [...] bit.ly/4bxPZFq

Amino acid cocktail improves mRNA delivery. bit.ly/4tbsUyj

Shin and Kim et al. demonstrated that VISTA deletion enhanced macrophage and CD8+ T cell infiltration and reduced tumor growth in orthotopic Pan02 and KPC pancreatic mouse tumor models.
bit.ly/3PsifR0