Check out the cover of @cp-trendsimmuno.bsky.social !! Art by lab alumna Sammy Tse, highlighting our lab's review in the issue by Khursheed Wani on enzymatic TIR proteins in innate immunity!!! www.cell.com/trends/immun...

Incredibly proud of Mo Nasrallah @umasschan.bsky.social MD,PhD graduate from my lab. So much fun to celebrate his accomplishments and those of his classmates this weekend. #UMassChan2025

Evolutionarily ancient functions of enzymatic TIR proteins in innate immunity Proteins with a Toll/interleukin-1 receptor/resistance (TIR) domain are among the most ancient immune regulators and include well-known pattern recognition receptors (PRRs). A specialized subset of TI...

Excited to share another review from the lab, this one by @khursheed01.bsky.social, out this week in
@cp-trendsimmuno.bsky.social . Join us for a fun tour of what we think are the coolest proteins in all of innate immunity! www.cell.com/trends/immun...

Patterns of pathogenesis in innate immunity: insights from C. elegans - Nature Reviews Immunology In this Review, Tse-Kang, Wani and Pukkila-Worley discuss how nematodes, such as Caenorhabditis elegans, rely on ‘patterns of pathogenesis’ as opposed to the sensing of specific ligands by pattern-rec...

In my first bsky post, I am excited to share our recent review out in @natrevimmunol.bsky.social. We discuss mechanisms that identify patterns of pathogenesis -- specific ligands or symptoms in the host that indicate active infection with an infectious microorganism. www.nature.com/articles/s41...