🚨In our new preprint we show that miRNAs act within a precise temporal window to control cell fate decisions in the human forebrain. 🧠
A study of miRNA expression dynamics and functions during early human brain development. @mdc-bimsb.bsky.social ‬
Check it out! www.biorxiv.org/content/10.6...

A symbiotic origin of the ribosome? Abstract. The origin of life is one of the great mysteries of science. Of the multiple unsolved problems, the origin of the translation system (the means b

"we propose that the protoribosome was a parasite (...). If this view is correct, then like the spliceosome in the stem eukaryote, a repurposed host-parasite interaction led to a dramatic change in cell biology at the base of the tree of life, in this case leading to the exit from an RNA world"

Does a cell’s gene expression always reflect its function? Transcriptionally similar neurons can be functionally diverse.

Evidence suggests that transcriptionally similar cells can be functionally diverse

go.nature.com/3N4lT2d

A summary schematic showing morphogen gradients in the developing human embryo, an overview of two screenings performed in the study (one testing factors related to patterning conditions, another one testing factors related to patterning reproducibility) and icons representing the main readouts of the screenings: organoid cell type composition, measures of morphogen interactions, primary atlas comparison and regulon activity.

Your new batch of cortical organoids resulted in mixed regional identities closer to hindbrain. Why is patterning so hard?😩

✨Our latest paper might help you✨
tinyurl.com/neorgpat

#morphogen #neuralorganoids #patterning #scRNAseq
@graycamplab.bsky.social @ethz.ch @nazbukina.bsky.social

HAPPY HOLIDAYS TO ALL OF YOU!🎄✨

What Rosalind Franklin truly contributed to the discovery of DNA’s structure Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.

Getting Rosalind Franklin’s story right is crucial, because she has become a role model for women going into science

www.nature.com/articles/d41...

Brain organoids are getting better at mimicking brains in a dish. But how good is too good? I take a look at the latest developments in my story today in the Times. Gift link: nyti.ms/496PPnC

I think the key for target prediction is not to rely on a single prediction tool. We typically use TargetScan, miRDB, and/or miRanda, then cross all three datasets to keep only the predicted targets common to all. The list gets shorter, but way more reliable! Good Luck! ✨

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

Group picture in Puerto Varas, Chile

🚀 Another edition of the Molecular Biosystems Conference is in the books! #mbiosys25

Thank you to our amazing speakers, participants, and sponsors, including ICGEB and @unubiolac.bsky.social, for making Puerto Varas a hub of exciting discussions on gene regulation and functional genomics. 🔽

Brain Surfaces of 70 primate species

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To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!

🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

Quantification of transcript isoforms at the single-cell level using SCALPEL - Nature Communications Single-cell RNA-seq facilitates the study of transcriptome diversity in individual cells. Here, authors introduce a tool for isoform quantification at the single-cell level using 3’ scRNA-seq data, co...

I’m really happy to present #SCALPEL, a new #Nextflow tool to quantify transcript isoforms at the single-cell level using conventional 3’ scRNA-seq data #scRNA-seq #single-cell #tools #isoforms
www.nature.com/articles/s41...