Another preprint from our group @mdanderson.bsky.social led by talented postdoc @seantbres.bsky.social! Joint with @jonhuang.bsky.social, exploring the intersection of environmental toxins, maternal/fetal health, and placental txomics. Tweet thread below!
New work by talented postdoc @taylorhead.bsky.social in our group @mdanderson.bsky.social! Tweet thread below:
Thank you for the PSA for obviously everyone else
The rest of the team would struggle to be on the bubble
We are getting so many of these recently. It’s so frustrating.
It’s open-weighted though
Excited to see everyone in Boston at #ashg25! 🧵on my group’s presentations.
Sean and Yung-Han both were awarded travel awards for their presentations, underscoring the importance of their work and the hard work they've put in for these projects. Looking forward to #ashg25.
Star PhD student @ytchang11.bsky.social will present an empirical Bayes method to formally test the replication composite null hypothesis in GWAS, effectively controlling FDR and maintaining strong power. Big downstream implications to check out in her pre-print: www.medrxiv.org/content/10.1....
@seantbres.bsky.social will talk about a placental long-read RNA-seq isoform reference + how using it with short reads improves transcript quantification and DTE/U analyses. Cool results in the preprint below. More maternal-fetal health work soon in GxE/POE analyses.
www.biorxiv.org/content/10.1...
Taylor also was recently nominated internally and submitted an early K99/R00 award to NCI. She did a tremendous amount of work for a really exciting proposal!
@taylorhead.bsky.social will talk about integrating long-read based transcript assemblies can improve QTL mapping and GWAS integration for breast cancer risk, building off her recent work showing eQTL colocalization and TWAS are HIGHLY sensitive to annotation choice.
www.biorxiv.org/content/10.1...
Presentations for Taylor Head (Room 205ABC Level 2 at 11:15 am on 10/15), Sean Bresnahan (Room 253ABC Level 2 at 8:45 am), and poster for Yung-Han Chang (Board 1108T, 2:30-4:30 pm on 10/16)
A few programming notes for #ashg25 from trainees in my group @mdanderson.bsky.social + a thread of me being a proud PI. Please drop by these sessions and talk to @taylorhead.bsky.social, @seantbres.bsky.social , @ytchang11.bsky.social, and me in Boston @geneticssociety.bsky.social next week!
Super excited to get this out. This collab started a few years ago and is the first paper from it. Here, with experimental and computational approaches we:
1. establish that cell villages can be just as accurate (one might argue more accurate!) than arrayed-based designs
bsky.app/profile/bior...
When testing a computational data analysis method: simulated data are good for checking whether the method is doing what you think it should be doing, real data for checking whether what you think it should be doing is any good.
On a personal note, I'm honored to be named an Emerging Leader by BJC! We're excited to continue our work in genomic mechanisms for cancer risk and progression to discover novel biomarkers for risk stratification and prognosis.
www.nature.com/collections/...
Very proud of @ytchang11.bsky.social for her first publication from her doctoral research! She conducted very meticulous genomic analyses that uncovered novel isoform-specific mechanistic hypotheses underlying genetic loci associated with multiple cancers.
www.nature.com/articles/s41...
Excited to share this preprint from first author Jon Rosen, a postdoctoral fellow in the @klmohlke.bsky.social lab and my lab. We examine eQTL study sample size and how this affects signal discovery and rates of colocalization with GWAS.
www.biorxiv.org/content/10.1...
⚡🦠I'm very excited to share our latest work on the gut microbiome and metabolic dysfunction-associated steatotic liver disease (MASLD) is published in @natmetabolism.nature.com, with @hutlab.bsky.social & @longnguyen.bsky.social!
🔗Check out the paper here:
www.nature.com/articles/s42...
New work from the lab trying to wrap our heads around the massive complexity of the human transcriptome revealed by long-read RNA-seq! Fun collab with Gloria Sheynkman. www.biorxiv.org/content/10.1...
Excited to share new work investigating transcriptional diversity in the placenta from our group led by talented postdoc @seantbres.bsky.social! Thread below describing the salient results. Welcoming any feedback and comments.
Much more important things going on in the world, but wanted to share this new work on parent-of-origin effects & “non-canonical” genomic imprinting in developmental plasticity of honey bees, out now in Genome Biology 🧪🧬🔄 link.springer.com/article/10.1...
Drop by and say hi to @mdanderson.bsky.social Postdoctoral Data Scientist @seantbres.bsky.social if you’re at Biology of Genomes. He’ll be presenting some new work from our group that he’s championed. You’ll have an interesting science and/or science policy discussion!
UNC beats Duke in Women's basketball--53-46 in OT
Neglected to share this good news this morning :)
Friends and colleagues, I’ve written a book on effective functional genomics study design, which will be available on Amazon in a couple of weeks. Sharing the TOC to spark interest. I hope students and those planning genomics experiments will find it useful! I’ll share updates soon
No espresso martinis for Lola?
🎉 I'm starting my own lab at EMBL-EBI (Cambridge, UK; June 2025) 🎉
We will focus on identifying and characterizing chemical hazards to humans and ecosystems using computational biology methods.
I am beginning the search for two postdocs now - stay tuned for more details!
ewaldlab.org
DEADLINE EXTENDED to Jan. 21! Open to grads & undergrads, join the world of cancer prevention this summer Jun 3 to Aug 9 at MD Anderson with an NCI funded internship working with too cancer researchers & clinicians! Apply at bit.ly/CPRTP-Summer
Thanks, Mike!
