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Posts by Sebastian Kittelmann

Fantastic news, congratulations Lauren!

4 weeks ago 1 0 0 0

If you'd be interested in a postdoc with us using CT scans of trilobite eyes to model their visual abilities, watch this space...!

4 weeks ago 11 8 0 0

Excited to share my first preprint from my PhD w/ @justinmcrocker.bsky.social. We show that cell type-specific regulatory dominance promotes robustness and evolutionary innovation through interallelic transcriptional hubs, potentially expanding the mutational paths available to diploids. (1/18)

1 month ago 42 22 1 3
View of the historic hotel Pousada Castelo in Palmela.

View of the historic hotel Pousada Castelo in Palmela.

Calling all #Drosophila #NewPI #researchers!
A few spots remain for the upcoming JEDI Conference - and you won’t want to miss this!

Every attendee gives a talk, making the exchange dynamic, personal, and highly interactive - all at a stunning venue that inspires collaboration and creativity.

1 month ago 22 17 0 4

Do you work with a strange model species and are frustrated by the lack of antibodies for immunos? Here's a web app that does some computational pre-screening for you.
sixpack-abscan.serve.scilifelab.se

1 month ago 12 8 1 0
Heliconius erato demophoon sat on a pink, yellow and white lantana flower. The left side of the butterfly is white, while the right side is the usual black and red, but with some white clonal patches.

Heliconius erato demophoon sat on a pink, yellow and white lantana flower. The left side of the butterfly is white, while the right side is the usual black and red, but with some white clonal patches.

New preprint form me and the McMillan lab at STRI and Martin lab at GWU, digging into scale cell type specification and differentiation in Heliconius wings, with some insights on the lncRNA gene ivory.

www.biorxiv.org/content/10.6...

Comments/suggestions welcome!

1 month ago 54 18 1 0

Thrilled to share that our preprint has been accepted in Science Advances! Grateful to an incredible team & collaborators.

Link: www.science.org/doi/10.1126/...

👏 @annaferraioli.bsky.social @maikekittelmann.bsky.social
@msarscentre.bsky.social @erc.europa.eu @hfspo.bsky.social #ctenophores

1 month ago 69 17 2 2
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We recommend a read of the new MBE editorial on how society journals work towards protecting the scientific record.

Publishing in society journals, such as @molbioevol.bsky.social or @genomebiolevol.bsky.social, promotes transparent science that benefits the research community.

1 month ago 3 4 0 0
ShineGAL4 FLP-out clones

ShineGAL4 FLP-out clones

#Drosophila calling. Delighted to share our new collection of ShineGAL4 drivers for CNS, FB, muscles, enterocytes, oenocytes and MTs made by @vgirard.bsky.social, @sebsorge.bsky.social and colleagues @crick.ac.uk. All at Bloomington @bdsc.bsky.social

@dev-journal.bsky.social
tinyurl.com/4jpw9jd6

1 month ago 49 24 1 2
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New pre-print with some updates on ivory:miR193 in a highly polymorphic moth.

www.biorxiv.org/content/10.6...

We mapped ivory (again!?) this time controlling aspects of camouflage in Anticarsia gemmatalis. Mapping, SVs, Expression and Function.

Comments/suggestions welcome!

1 month ago 35 14 0 2
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Join us for a day of talks, posters, and discussions, featuring a morning joint lecture with Nobel Laureates Eric F. Wieschaus and Christiane Nüsslein-Volhard!
Date: Monday, May 4th, 2026
Location: University of Copenhagen, Mærsk Tower
sites.google.com/view/emergin...
Free to participate

1 month ago 23 20 1 0
An advertisement for a PhD position studying "Revealing the mechanistic basis of defence peptide antibacterial specificity." It shows fruit flies infected by green-fluorescent protein expressing bacteria, and describes the project and way to apply.

An advertisement for a PhD position studying "Revealing the mechanistic basis of defence peptide antibacterial specificity." It shows fruit flies infected by green-fluorescent protein expressing bacteria, and describes the project and way to apply.

Very excited to be advertising this project with the excellent cosupervision of Peter Mergaert through @i2bcparissaclay.bsky.social and @uniexecec.bsky.social.

This position is open to international applicants and will involve stints in both Penryn UK and Paris France. Please share!

Apply: adum.fr

1 month ago 18 25 1 0
Fluorescent neurons on black background. We're hiring! PhD Student

Fluorescent neurons on black background. We're hiring! PhD Student

🚨 We are #hiring a PhD Student to study cerebellum-like circuits in #Drosophila.

Please spread the word!

www.groschner-lab.org/join

#Neuroscience #PhD

2 months ago 15 18 0 1

One week to go to apply for this PhD project with me, Dani Nunes, and Darren Williams!

2 months ago 0 0 0 0
addison-wheeler-fellowship - Durham University

🚨 Postdoc opportunity to study memory or nutrition in #Drosophila 🪰

I am looking for a candidate to support for a 3 year Addison Wheeler Fellowship application lnkd.in/e2rvNf5x

Interested? Please send a CV & cover letter with brief research outline by 20th February to vincent.croset@durham.ac.uk

2 months ago 15 21 0 1
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Look at the replies and then understand why I yell at the nonsense initiatives the EU has pulled instead of reinforcing what we already have 🧪

2 months ago 18 8 4 0

Very last chance to join us (Deadline tomorrow Feb 10!) at this Developmental Biology meeting!
Have a nice story? Come and discuss it with editors from @embojournal.org @plosbiology.org and @dev-journal.bsky.social !
A one hour info session from @erc.europa.eu will also be presented!

2 months ago 8 13 0 2
Home | Timothy Fuqua

I'm looking for a Swiss department to host me for an SNSF Starting Grant.

I research how gene expression evolves and emerges by combining wet lab + computational work in a variety of model systems (E. coli, Drosophila, yeast). More: timothyfuqua.com

If your department might be a match, let’s chat!

2 months ago 4 4 0 0

I am looking for examples of a 2-3 hour lab activity for a course that would allow college students to get some experience connected to environmental DNA studies (e.g., e-DNA, rRNA/ITS PCR, metagenomics, etc). Ideally this would have some DNA extraction and some follow up processing / analysis.

2 months ago 20 23 7 0
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Davis Summer Population Genomics Program Want to learn population genetics? Please fill out this form to indicate your potential interest in a 2-week intensive online summer population genetics course taught by Jeffrey Ross-Ibarra and Graham...

Fun news! @gcbias.bsky.social and I are teaching a 2-week online population genetics workshop this summer to raise money for the Center for Population Biology at UC Davis. We're trying to gauge interest -- please fill this out if you might be interested! And please share broadly!

2 months ago 140 168 6 6

Abstract submission and registration for the *10th Euro Evo Devo Meeting 2026* at University of Glasgow (June 8-12, 2026) is open. Early bird deadline: March 5, 2026. More info: https://www.evodevoconference26.com/ #conference

2 months ago 7 9 0 1
A global map showing that most people don't talk about or hear about climate change regularly (except in Scandinavia - I believe this is the Greta Effect!). Source: Yale Program on Climate Change Communication.

A global map showing that most people don't talk about or hear about climate change regularly (except in Scandinavia - I believe this is the Greta Effect!). Source: Yale Program on Climate Change Communication.

A global map showing that most people are worried about climate change. Source: Yale Program on Climate Change Communication.

A global map showing that most people are worried about climate change. Source: Yale Program on Climate Change Communication.

Most people are worried about climate change - but most don't hear or talk about regularly.

That's why I started my free newsletter Talking Climate. Every week I share good news, not so good news, and what people can do.

If you aren't a reader yet, see below. I have 6 different ways to subscribe!

2 months ago 425 159 6 6
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New #PhD on #bees (BeeHd?)! Despite the ad saying "UK Students only", a limited number of scholarships are available for international candidates. So please apply!

2 months ago 33 39 0 1
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MRC instructs grant review boards to slash funding rates - Research Professional News Boards asked to recommend just three applications for funding, as BBSRC also suspends calls

Both MRC and BBSRC responsive modes now withdrawn until further notice. Existing applications unlikely to succeed (late 2025 round expecting 1-5% success rate).

Listen, I get that UKRI wants to pivot. But killing both at once is devastating.

Let's hope at least one opens by summer... #AcademicSky

2 months ago 28 30 4 7
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Molecular Mechanisms of Transcription Factors with Dual Activator and Repressor Functions Transcription factors (TFs) are traditionally classified as activators or repressors, yet some can perform both roles. We highlight well-supported examples of dual activator/repressor functions and...

this mini-review was fueled by frustration with others who use "context-specific" to describe transcription factors that supposedly can function as repressors or activators: www.tandfonline.com/doi/full/10....

2 months ago 6 3 1 0

Thanks @elife.bsky.social for this thread on @brunolemaitre.bsky.social and all's immense work assessing the field's reliability!

For #Metascience folks: what's unique about the #Drosophila model is access to independent tools. Most studies use multiple approaches to test their key questions.

1n 🧵

2 months ago 13 7 1 0

I'm seeing relatively little chatter or outcry about what is happening at the MRC, the UK's biomedical research funder.

Before Christmas MRC paused the acceptance of many of its grants, including the standard applicant-led research grant. There has been no public information on what is happening 🧵

2 months ago 14 21 4 3
In vivo kinetics of protein degradation by individual proteasomes Protein degradation by the proteasome is central to cellular homeostasis and has been studied extensively using biochemical and structural studies. Despite an in-depth understanding of core proteolytic activity, it has remained largely unresolved how individual proteasomes process substrates inside living cells where many substrate types and co-factors exist. Here, we establish a live-cell single-molecule imaging approach that enables direct visualization and quantification of protein degradation by individual proteasomes. Using this approach, we find that substrate identity, folding and protein-protein interaction have a surprisingly modest impact on processing efficiency, whereas the mode of substrate engagement greatly impacts substrate processing; degradation initiated from protein termini typically proceeds rapidly and with high processivity, whereas internal engagement constitutes a distinct processing mode that exhibits poor processivity and a specific requirement for the AAA+ family ATPase p97/VCP. Furthermore, degradation initiated from opposite termini proceeds with asymmetric rates in a sequence-dependent manner, demonstrating that directionality is an important feature of proteasomal processing in vivo. Notably, poly-glutamine substrates associated with neurodegenerative disease are efficiently degraded from one terminus but resist degradation when engaged from the opposite terminus, highlighting the importance of substrate engagement mode. Together, our results show that different modes of substrate engagement lead to different proteasomal processing outcomes in vivo and revise the prevailing view of the proteasome as a uniform degradation machine. ### Competing Interest Statement The authors have declared no competing interest.

New lab paper!! We develop a technology for real-time, single-molecule visualization of proteasomal substrate degradation in cells. We find that the site of substrate engagement by the proteasome determines decay kinetics, efficiency and co-factor requirement.

www.biorxiv.org/content/10.6...

3 months ago 47 15 1 2
PhD in Nigel Groome Studentship: Unravelling Context-Specific Hormonal Control of Gene Expression in Drosophila at Oxford Brookes University The regulation of gene expression underlies nearly every biological process in eukaryotes. It is facilitated through transcription factors (TFs), which bind to DNA and influence mRNA product...

Interested in hormonal control of development? Want to do your PhD in a supportive environment using flies, molecular biology, genetics, imaging, sequencing? A month to go to apply for this studentship with me, co-supervised by Dani Nunes and Darren Williams. www.brookes.ac.uk/courses/rese...

3 months ago 1 3 1 0

Congrats to the whole team (none of whom are on Bluesky), especially leading postdoc Sean Hubbert and my partner-in-crime Korneel Hens! Please get in touch if you want any of the materials before they are in public repositories.

3 months ago 1 0 0 0
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