Together, our data suggest that different NRXN1 deletions can give rise to distinct behavioral outcomes, underscoring the importance of considering deletion type when interpreting NRXN1 variants.

Key findings:
• NRXN1 isoform-specific deletions produce distinct behavioral phenotypes
• Behavioral phenotypes emerge early in development
• α-specific loss does not fully recapitulate whole-gene deletion

Excited to share the first preprint from our lab! Our work examines how isoform-specific NRXN1 deletions—a gene strongly associated with neurodevelopmental disorders—shape sensorimotor and social behavior in zebrafish. www.biorxiv.org/content/10.6...

#Neurodevelopment #Genetics #Zebrafish

Campbell Lab Current treatments for neuropsychiatric disorders are largely inadequate. At the core of this issue is a lack of understanding of the biological mechanisms underlying these disorders. How do we begin ...

Please DM or email if interested! sites.google.com/view/campbel...

We are looking to hire at all levels - undergrads, research technicians, graduate students, postdocs. Experience with zebrafish, induced pluripotent stem cell models, molecular genetic approaches, imaging, or programming is desirable but not required.

We use the zebrafish system to understand how genetic variants associated with neurodevelopmental disorders such as schizophrenia and autism generate brain and behavioral phenotypes with the goal to identify novel mechanistic insights, disease biomarkers, and treatments.

I am excited to announce that I will be starting my own lab in the Department of Psychiatry at the University of Pennsylvania next month!