a man with long hair is sitting in front of a laptop computer . ALT: a man with long hair is sitting in front of a laptop computer .

When the first mice from a double conditional KO that took 16 months to generate show a massive phenotype (that looks exactly like you hoped it would). @thejenjay.bsky.social

Co-authors Dr Kevin Wright & Dr Jennifer Jahncke join Dr Chang Sun, a former Gouaux Lab postdoc & lead author, in a study published in @pnas.org . This research could help scientists design more targeted brain medicines.
@kevinmawright.bsky.social @thejenjay.bsky.social www.pnas.org/doi/10.1073/...

Microscope built on rails

🔬We are now accepting applications for the 2026 Analytical and Quantitative Light Microscopy course at MBL. Come learn to be an excellent microscopist!
Questions? Ask here or DM me.
@mblscience.bsky.social @aqlm.bsky.social
#microscopy #fluorescence

Yes I have contacted the pain clinic to let them know this keeps happening, *hoping* they would find wherever they’ve listed the wrong number, but alas the calls keep coming.

Perhaps my favorite piece of Wright Lab lore is that we have a lab phone that we never ever use but every couple of weeks it rings and without fail it is a patient trying to call the hospital’s pain clinic and we just give them the right number and go about our day. We’re essentially a switchboard.

Right there with you! Such a privilege to stare at them all day.

I’m 32 years old and today I did a LOT of algebra for an image analysis pipeline I’m developing. Tell your kids - you never know when that shit will come in handy.

I love her.

And just like that, #AQLM2025 is over. Hopefully we’ll all find ourselves in the same windowless microscope room sometime soon, bead slide in hand.

Y’all should follow @aqlm.bsky.social to keep up with the cool topics in microscopy we’re covering this year! (I’m the social media intern)

Are the checks and balances in the room with us now?

I *would* say that we are going to see incredibly devastating [health, humanitarian, environmental] impacts of the current administration, but they’re making that data inaccessible. Interesting tactic, I wonder where they got the idea…

Inhibitory CCK+ basket synapse defects in mouse models of dystroglycanopathy Loss of functional dystroglycan disrupts the formation and function of CCK+/CB1R+ inhibitory synapses in hippocampal CA1, resulting in reduced seizure thresholds in mouse models of dystroglycanopathy.

Version of Record: elifesciences.org/articles/879...
Congrats to @thejenjay.bsky.social and collaborators for their hard work, and thanks to NINDS, CureCMD and MDA for funding this project looking at hippocampal synapse function in mouse models of dystroglycanopathy

🥳 thanks! Now I just need to…write.

It’s official! Defense date set for March 4th 😎

😂

Haha apparently we can’t do gifs here??? Just gotta lean into it.

Our program also differentiates between thesis (masters ) and dissertation (PhD). But I think more importantly: OHSU loves acronyms - masters students have TAC meetings 😂

HOW is this only your first one! Everyone is going to be so psyched about your progress.

All I have to say about electrophysiology is that no other technique has made me bleed.

Tree branches, right?

On the confocal all day today and tomorrow to crank out a huge dataset. Look at those little Purkinje cell axonal swellings in the cell body layer! Not sure who they’d be talking to in that location. Some could be PC:PC?

Magenta: Calbindin
Red: VGAT
Green: GABAAa1

Two feeding chairs for dogs. The one on the left is bigger and contains a corgi eating. The one on the right is smaller and contains a small black dog eating.

I just want more people to know that both of my dog children have megaesophagus and they eat their meals side by side in their special little feeding chairs.