Congratulations! Exciting work; it seems like CeA is critical for hedonic food consumption, who would have guessed 😉

Chemogenetic inhibition of CeA GLP-1R neurons resulted in a strong rescue of Ex-4-mediated reductions in high fat diet intake using a hedonic intermittent access paradigm. This suggests that this cell type is playing a pivotal role in the neural circuitry mediating reductions in appetite by GLP-1s.

Anatomical and Functional Characterization of Central Amygdala Glucagon-Like Peptide 1 Receptor Expressing Neurons - PubMed Glucagon-like peptide 1 receptors (GLP-1Rs) are highly expressed in the brain and are responsible for mediating the acute anorexigenic actions of widely prescribed GLP-1R agonists. Neurobiological efforts to localize the hypophagic effects of GLP-1R agonists in the brain have mainly focused on the h …

But what about the target of these drugs? Those that express the GLP-1 receptor. Turns out the CeA has many cells that express GLP-1R, enriched in the medial portion. Our initial characterization here:

pubmed.ncbi.nlm.nih.gov/35002645/

But is this just an association or is there a causal relationship? Here's where we used inhibitory chemogenetics combined with an army of FED3s (hat tip @kravitzlab.com) to assess whether activation of the CeA was required for the hypophagic actions of Ex4.

Really thrilled to share my lab's latest work where we characterize the role of the CeA in integrating exogenous GLP-1 signals.

www.biorxiv.org/content/10.6...

Merck to buy Terns in $6.7 billion deal The New Jersey pharma giant will acquire a suite of cancer molecules

Terns is developing drugs for cancer and weight loss. Its lead candidate is TERN-701, a small molecule designed to treat chronic myeloid leukemia.

#chemsky 🧪

Illustration showing side profiles of two humans with highlighted brains, accompanying text about a new database mapping brain development across species.

🧠 BREAKTHROUGH: UMSOM researchers at @genomescience.bsky.social created NeMO Analytics, a massive multi‑omic database combining data from 188 studies — revealing new insights into how the neocortex develops across species.

📰 More: bit.ly/4uPvLP3

#Neuroscience #BICAN #BrainResearch #Medsky #MedEd

At least 10 times a game...

Sir Ian McKellen performing a monologue from Shakespeare’s Sir Thomas More on the Stephen Colbert show. Never have I heard this monologue performed with such a keen sense of prescience. Nor have I ever been in this exact historical moment.TY Sir Ian, for reaching us once again.
#Pinks #ProudBlue

This is amazing 👇

It was great having you visit. Thanks for a great seminar and looking forward to new collaborations. Safe travels.

Timing may be key to effective cancer treatments Researchers at Washington University in St. Louis find the timing of biopsy can affect how doctors diagnose tumors and when those cancers may be more sensitive to chemotherapy.

Dosing on the way down improves outcomes for glioblastoma. Thanks Maddy Frank for covering this collaboration with @oliviawalch.bsky.social and WashU grad student @mariafelicita.bsky.social. #chronotherapy #circadian #medicine source.washu.edu/2025/11/timi...

Therapeutic VEGFC treatment protects against traumatic brain injury-driven tauopathy pathogenesis @cp-cellreports.bsky.social
www.sciencedirect.com/science/arti...

Circadian variation in MGMT promoter methylation and expression predicts sensitivity to temozolomide in glioblastoma - Journal of Neuro-Oncology Purpose Recent studies show that glioblastoma (GBM) is more sensitive to temozolomide (TMZ) in the morning. In cells, inhibiting O6-Methylguanine-DNA-Methyltransferase (MGMT) abolished time-dependent ...

#Circadian #medicine tests if treatment timing can improve patient outcomes. This paper by @mariafelicita.bsky.social @oliviawalch.bsky.social et al considers #chronodiagnostics ...how the outcome of a standard test for glioblastoma differs with time of biopsy. link.springer.com/article/10.1...

Review of applications will begin in 5 days!

I have been trying to get this published as an op-ed, but I am going to post it here since I think it is timely in light of the "consent" extortion events.

Deafening Quiet from the Scientific Establishment

jeremymberg.github.io/jeremyberg.g...

1/14

Interested in a tenure track position teaching and doing research with undergrads at a PUI? We are looking for a broadly-defined microbiologist who can teach Med Micro and Immunology. Apply at universityofscrantonjobs.com/postings/8308. Pls share widely to feeds (& on twitter if you still tweet)! 🦠

Trump Is Shutting Down the War On Cancer

I am not a political pawn. I am a living, breathing human being who has dedicated her life to a scientific problem that I believe matters for human health. The article below tells our story; I hope you will read it and share it www.nytimes.com/2025/09/14/m...

Don't miss this opportunity to be our colleague! Very exciting initiative here at UVA!

Come be my colleague! Happy to answer any questions about what it's like living in Charlottesville and being in the department.

We welcome applicants working on:
• Neural circuits & plasticity
• Glia & brain interactions
• Behavioral genetics & genomics
…and more!
Join a highly interdisciplinary department with access to state-of-the-art imaging, genomics, metabolomics, and computing resources.

At UVA, you’ll be part of a vibrant, collaborative neuroscience community spanning Biology, Medicine, Engineering, Data Science & more... in beautiful Charlottesville, VA. 🌄
Apply today & help shape the future of neuroscience:
👉 apply.interfolio.com/172892

🚨 We’re hiring! 🧪 @uvabio.bsky.social
UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠
Apply by Oct 15, 2025. Start Aug 2026.
👉 apply.interfolio.com/172892
#Neuroscience #FacultyJobs #NeuroJobs #Biology #UVA

At UVA, you’ll be part of a vibrant, collaborative neuroscience community spanning Biology, Medicine, Engineering, Data Science & more... in beautiful Charlottesville, VA. 🌄
Apply today & help shape the future of neuroscience:
👉 apply.interfolio.com/172892

We welcome applicants working on:
• Neural circuits & plasticity
• Glia & brain interactions
• Behavioral genetics & genomics
…and more!
Join a highly interdisciplinary department with access to state-of-the-art imaging, genomics, metabolomics, and computing resources.

🚨 We’re hiring! 🧪 @uvabio.bsky.social
UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠
Apply by Oct 15, 2025. Start Aug 2026.
👉 apply.interfolio.com/172892
#Neuroscience #FacultyJobs #NeuroJobs #Biology #UVA

It is impossible to explain to civilians how it feels to finally, FINALLY, land a clearly within-payline NIH grant score and then have it go unfunded because of all this regime bullshit.

You all have my sympathies. Unfair doesn’t even begin to describe it.

GIP receptor agonism suppresses inflammation-induced aversion and food intake via distinct circuits www.biorxiv.org/content/10.1101/2025.08....

Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...

These are the most challenging times for early-career scientists and engineers.

My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.

We found 437 of them.

Download it freely here: research.jhu.edu/rdt/funding-...