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Posts by Sam Hemmings

Closing the gap on antifungal resistance - Nature Medicine Drug-resistant fungal disease must be addressed in the 2026 update to the Global Action Plan on Antimicrobial Resistance

The global mycology community calling for an effort to combat drug‑resistant - Closing the gap on antifungal resistance www.nature.com/articles/s41...

4 days ago 8 3 0 0

First day back after a great time in Belfast at #MicroSoc26 @microbiologysociety.org. Thank you to the organisers for the opportunity to present my work. Which, if you missed, is now currently available on bioRxiv!

4 days ago 5 2 0 0
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Air pollution making people in UK get long-term illnesses earlier, study finds Pollution is ‘silent accelerator that robs individuals of their healthiest years’, say researchers

"Air pollution acts as a silent accelerator that robs individuals of their healthiest years.”

My latest piece for @theguardian.com on research on 396,000 people in the UK.

www.theguardian.com/environment/...

4 days ago 28 19 0 1
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‘Without them there is no life’: the race to understand the mysterious world of Africa’s fungi Amid growing evidence of fungi’s key role in ecosystems and storing carbon, African scientists are championing the need to preserve ‘funga’ as much as flora and fauna

Fungi make so much of life on earth possible—but are too often left out of conservation.

That's slowly starting to change. As it does, a cohort of mycologists across Africa are pioneering the study and conservation of fungi in their home countries. My latest: www.theguardian.com/environment/...

6 days ago 44 15 1 1
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GitHub - bacpop/ggCaller: Bifrost graph gene caller. Bifrost graph gene caller. Contribute to bacpop/ggCaller development by creating an account on GitHub.

ggCaller v1.5.0 is out! We've removed the integrated clustering to enable users to benefit from new Panaroo features. Now, ggCaller generates GFFs that can be used with any clustering method. But for fans of an integrated ggCaller pangenome workflow read on...

github.com/bacpop/ggCal...

3 weeks ago 21 12 1 0
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New review article

WHO assessment of the preclinical #antifungal pipeline: evaluating innovation and preparedness in the face of emerging fungal threats

www.thelancet.com/journals/lan...

#IDSky #ClinMicro #MycoSky #OpenAccess #OA

3 weeks ago 2 3 0 2
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Researchers launch forecasting challenge to help predict severe patient harm in NHS hospitals Researchers have launched a new data science challenge aimed at improving the ability of NHS hospitals to anticipate and prevent severe patient harm.

Develop a forecasts of severe patient harm to be used by the NHS!
Every 4-hour delay in Emergency Department admission increases 30-day mortality risk by 8%: join the SPHERE forecasting contest and help the NHS reduce delays before they happen!
Find out more here: www.imperial.ac.uk/news/article...

3 weeks ago 2 1 0 0
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Transposable elements hitchhike on Starships across fungal genomes - Nature Communications Large mobile genetic elements known as Starships act as vehicles for transferring transposable elements (TEs) between fungi. Here, Griem-Krey et al. show that these ‘hitchhiking’ TEs can drive rapid e...

Now out!
We show that TEs can be horizontally transferred between fungal species via Starships. Once transferred, these TEs can become active, changing the genome organization and affecting the lifestyle of the recipient fungus.
www.nature.com/articles/s41...
@oggenfussursula.bsky.social #TEsky

3 weeks ago 87 56 0 2
Antarctic marine microplastics reveals environmental persistence and rapid evolution of Candida auris Candida ( Candidozyma ) auris is a critical priority fungal pathogen that emerged two decades ago near simultaneously on multiple continents. Since emergence, C. auris resistance to all four classes of antifungal drugs has been described, including pan-drug resistant isolates, sometimes evolving in-patient. Here, we confirm the first isolation of C. auris from Antarctica and show cold-adapted phenotypes and an affinity for binding to nylon. We also provide evidence to suggest mutator phenotypes contribute to the rapid evolution in C. auris and are responsible for the emergence of multiple, distinct genetic clades worldwide. Isolates in clades I, III and IV with a mutator phenotype displayed elevated mutation rates compared to non-auris Candida species. This phenotype had a complex genetic basis and was associated with drug resistance mutations. We postulate that the mutator phenotype has a significant effect on evolutionary potential and is responsible for the emergence and rapid spread of drug-resistance C. auris and novel genetic clades. ### Competing Interest Statement This work was partially support by a Wellcome Trust Institutional Strategic Fung Springboard Fellowship awarded to JR. PH and JR were funded through a JPIAMR IMPACT grant (JPIAMR2024_IMPACT-197 Consortium grant: FuGACI) and the Dutch Organisation for knowledge and innovation in health, healthcare and wellbeing (ZonMw) under project number 10570172410003. NvR is supported by a Wellcome Trust fellowship (226408/Z/22/Z). MCF is a fellow of the Canadian Institute for Advanced Research (CIFAR). RAF is supported by a Wellcome Trust Career Development Award (225303/Z/22/Z). JLS is a Howard Hughes Medical Institute Awardee of the Life Sciences Research Foundation. SD and HG are supported by the MRC Centre for Medical Mycology at the University of Exeter (MR/N006364/2 and MR/V033417/1), and the MRC Doctoral Training Grant (MR/P501955/2), and the NIHR Exeter Biomedical Research Centre. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. We also thank the Exeter Sequencing Service facility and support from Wellcome Trust Institutional Strategic Support Fund (WT097835MF), Wellcome Trust Multi User Equipment Awards (WT101650MA and 218247/Z/19/Z), Medical Research Council Clinical Infrastructure Funding (MR/M008924/1) and BBSRC LOLA award (BB/K003240/1), as well as the University of Exeter High-Performance Computing (HPC) facility, funded by the UK MRC Clinical Research Infrastructure Initiative (award number MR/M008924/1). Wellcome Trust, https://ror.org/029chgv08, Strategic Fung Springboard, 226408/Z/22/Z, 225303/Z/22/Z JPI-AMR, JPIAMR2024_IMPACT-197 Consortium grant: FuGACI ZonMw, The Dutch Organisation for knowledge and innovation in health, healthcare and well-being, 10570172410003 CIFAR Howard Hughes Medical Institute Awardee of the Life Sciences Research Foundation MRC Centre for Medical Mycology at the University of Exeter, MR/N006364/2, MR/V033417/1 MRC Doctoral Training Grant, MR/P501955/2 NIHR Exeter Biomedical Research Centre BBSRC, BB/W009625/1 MRC, MR/4002163/1

Excited to share our latest work:
“Antarctic marine microplastics reveals environmental persistence and rapid evolution of Candida auris.”

www.biorxiv.org/content/10.6...

This study explores how environmental microplastics may act as reservoirs for Candida auris.

đŸ§”

1 month ago 12 5 1 0
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✹NEW EPISODE✹ #ScienceInContext This week @eonore.bsky.social speaks with Prof Nicholas Grassly & Dr Joyce Akello about wastewater surveillance as early warning of viruses with pandemic potential & the WASPP Network👇
youtu.be/7sbL-Eq9U7A
@imperialcollegeldn.bsky.social @gatesfoundation.bsky.social

1 month ago 1 1 1 0
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A journey to run a polymerase chain reaction in the kitchen Did you know an air fryer can thermocycle?

Did you know an air fryer can thermocycle? Read the journey of two scientists’ attempts to run a PCR cycle in the kitchen, in the latest feature in #TheMicrobiologist.
www.the-microbiologist.com/features/a-journey-to-ru...

1 month ago 5 2 1 0
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🌟 New at #Fungal26—the inaugural Fungal Spore Lecture featuring Matthew C. Fisher (Imperial College London).
Working at the One Health interface, Fisher explores how antifungal use and global trade are reshaping the Fungal Kingdom. Join us for his lecture: buff.ly/oCNlI2l

1 month ago 7 4 0 1
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MycoMobilome: a community-focused non-redundant database of transposable element consensus sequences for the fungal kingdom Abstract. Transposable elements (TEs) are found in nearly all eukaryotic genomes. Despite significant advances in the sequencing of genomes, TE resources r

Need to annotate transposons in fungal genomes? 🧬
Good news #MycoMobilome is now live! Check it out here: doi.org/10.1093/narg...
Access the sequences through our Zenodo community (you can also contribute seqs with credit), and synchronisation with @dfam.bsky.social!

w/ @danielcroll.bsky.social

1 month ago 25 12 0 2
Poster of the call for abstracts fir the BMS Annual Scientific Meeting, with a photo of the Royal Holloway campus building at sunset..

Poster of the call for abstracts fir the BMS Annual Scientific Meeting, with a photo of the Royal Holloway campus building at sunset..

📣 Call for Abstracts - British Mycological Society 2026 Annual Scientific Meeting. Inviting researchers, early-career scientists, postgraduate students, & practitioners to share their latest research👉 Event webpage & abstract submission: www.britmycolsoc.org.uk/asm.html
#BMS2026

1 month ago 4 4 0 0
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New study in @nature.com finds pesticides in 70% of soils sampled across Europe, showing they suppress beneficial arbuscular mycorrhizal fungi. Authors call for assessing pesticide impacts on entire soil communities to better protect soil biodiversity.

Link to paper: buff.ly/wJzWiYB

2 months ago 9 5 1 0

How do bacterial pangenomes evolve, what controls their dynamics, why do they exist?
Fitting a mechanistic model to 450 species from allthebacteria.org suggesting fast vs slow gene exchange (i.e. amount of MGEs) is a major differentiating factor, correlated with phylogeny rather than lifestyle

2 months ago 71 32 1 0

At long last, my final PhD chapter is out: we developed a novel evolutionary simulator of bacterial pangenomes, Pansim, fitting it to data from >600K genomes using a likelihood-free framework, PopPUNK-mod, to explore neutral and adaptive pangenome dynamics www.biorxiv.org/content/10.6...

2 months ago 45 18 2 1
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Rarefaction is better than robust Aitchison PCA and other compositional data analysis methods at controlling for uneven sequencing effort Amplicon sequencing typically results in a wide distribution in the number of sequences obtained from each sample. How best to account for this variation has been a persistent problem in the microbial...

New paper up on bioRxiv! This is my third and hopefully final paper on rarefaction. It's still better than the other available methods.

www.biorxiv.org/content/10.6...

3 months ago 38 16 2 1
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Troubleshooting common errors in assemblies of long-read metagenomes - Nature Biotechnology Long-read sequence assemblies from metagenomes contain frequent errors.

Really important read for people working with long-read MAGs.
www.nature.com/articles/s41...

3 months ago 22 8 0 0
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đŸ”„ New study on invasive #mold infections in severe #burn patients. These infections affect ~20% of cases and are hard to distinguish from colonization. We analyzed 6,000+ samples from 276 patients to identify strategies that could improve mycological diagnosis.

🔗 bit.ly/4a4l6I0

2 months ago 6 2 0 1

Really proud of former PhD student Hugh Gifford for wrapping up this massive project, looking at almost 13k whole genome C. auris sequences 1997-2024! www.biorxiv.org/content/10.6...

2 months ago 9 1 1 0
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Ecosystem destruction will force the UK to tackle food security The UK’s approach to food makes it increasingly vulnerable in an unstable world. A great food transformation with a focus on resilience is urgently needed, argues Paul Behrens Last week the UK gover...

I wrote an op-ed for the @bmj.com on the UK government's national security assessment on ecosystem collapse and how we need act.

This report was released last week, delayed by months—allegedly it was seen as too negative by number 10—and abridgedđŸ§”

www.bmj.com/content/392/...

2 months ago 12 9 1 0
A graphic with dark blue background showing orange smoke‑cloud icons and text about Clean Air Night. The message reads: ‘We all want to stay warm this winter
 but cosiness shouldn’t cost the health of our communities. This #CleanAirNight share the uncomfortable truth about wood burning.’ Logos for Clean Air Night, Global Action Plan, and Impact on Urban Health appear at the bottom, along with the date 22 January 2026.

A graphic with dark blue background showing orange smoke‑cloud icons and text about Clean Air Night. The message reads: ‘We all want to stay warm this winter
 but cosiness shouldn’t cost the health of our communities. This #CleanAirNight share the uncomfortable truth about wood burning.’ Logos for Clean Air Night, Global Action Plan, and Impact on Urban Health appear at the bottom, along with the date 22 January 2026.

Many aren't aware that burning wood at home can seriously impact indoor and outdoor air quality. Tonight is Clean Air Night - learn about how to protect your health and your home:

www.actionforcleanair.org.uk/campaigns/cl...

2 months ago 70 24 1 3
'Research Associate in Microbiome Ecology:Manchester We wish to appoint a PostDoctoral Research Associate to an exciting project exploring the assembly, stability and function of microbial decomposer communities.

We're Hiring! We're looking for a postdoc with bioinformatics/modelling skills to join us in an exciting microbiome ecology project in Manchester (deadline 1st March) www.jobs.manchester.ac.uk/Job/JobDetai...

2 months ago 15 32 1 0
Microscopic view of a colony of Aspergillus fungi ©Gilnature/iStock

Microscopic view of a colony of Aspergillus fungi ©Gilnature/iStock

It’s World Aspergillosis Day! This article published in JMM examines the prevalence of azole resistance among clinical Aspergillus isolates. Read more about these resistance patterns here: https://doi.org/10.1099/jmm.0.002112
#WorldAspergillosisDay

2 months ago 13 6 2 1
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Imperial and DNDi strengthen partnership to accelerate treatments for neglected diseases Researchers from Imperial College London and the Drugs for Neglected Diseases initiative (DNDi) met on 19 January to strengthen a growing partnership...

On #WorldNTDDay, @imperialcollegeldn.bsky.social + @dndi.org strengthen their partnership to speed up new treatments for #NeglectedDiseases affecting 1 billion+ people worldwide. 🌍

From #AI to drug discovery, we’re working to turn science into real-world impact.

www.imperial.ac.uk/news/article...

2 months ago 10 8 0 0
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Earlham Institute and Natural History Museum launch deep tech startup Agnos Biosciencesℱ This new technology is a method for characterising biological particles in the air using a combination of novel molecular biology, DNA sequencing and bespoke computational analysis.

📣 Today Earlham Institute and @nhm-london.bsky.social announce a joint venture spin-out company Agnos Biosciences and its cutting-edge rapid #air #sequencing technology, AirSeq, to transform biological threat detection.

@ukri.org @richardmleggett.bsky.social

2 months ago 3 1 0 0
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Worried about plastic in your brain? Scientists say otherwise Claims that microplastics are contaminating the human body and threatening our health may have been exaggerated, experts say

“Take a breath before drawing conclusions.”

Professor Leon Barron from @imperialsph.bsky.social says some #microplastics studies may be overstated, and that more robust #research methods are needed before alarmist headlines.

More via @thetimes.com 👇 www.thetimes.com/uk/science/a...

2 months ago 3 1 0 0
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Emerging terbinafine-resistant Trichophyton indotineae between 2018 and 2023: a multinational genomic epidemiology study That no clear geographical clustering of isolates was observed confirms the rapid transcontinental spread of T indotineae from its likely centre of diversity in Asia. Our findings highlight the import...

Emerging terbinafine-resistant Trichophyton indotineae between 2018 and 2023: a multinational genomic epidemiology study - The Lancet Microbe www.thelancet.com/journals/lan...

2 months ago 3 2 0 0
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This year, the taxonomists on the Fungarium Sequencing Project had a goal to review 10,000 specimens. They hit their target an impressive three months ahead of schedule, so to celebrate their hard work, here are some of the stories they’ve uncovered!

2 months ago 35 8 1 0