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Posts by Woodson Lab

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19F NMR Strategy for Probing Site-specific RNA Dynamics in Large RNA-protein Complexes: Application to the Hfq RNA Chaperone Nuclear magnetic resonance (NMR) spectroscopy is uniquely suited to probing motions on the microsecond to millisecond timescales that underlie RNA rec…

Our new paper is out! Using 19F NMR, we show that Hfq rewires the conformational dynamics of a model sRNA in a site-specific manner. Uridines at the rim undergo faster exchange (~100 μs) than those in the proximal pore (~300 μs). Congrats Elise! 🎉🎉 www.sciencedirect.com/science/arti...

19 hours ago 12 6 0 3
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Congratulations to Anthony Henras, winner of the ERC Synergy 2025 grant! Parmi les 66 projets sélectionnés par le Conseil européen de la recherche, Anthony Henras et l’équipe EukaRiBio (MCD-CBI) sont lauréat d’un des 13 projets du

🎉 We’re excited to officially kick off the ERC Synergy project, snoOPERA, with Anthony Henras, Brigitte Pertschy, and Roland Beckmann! 🎉 Bringing together labs across 3 European countries and the US, we aim to uncover hidden functions of snoRNPs in ribosome assembly. Go team! tinyurl.com/2e5r57b5

2 weeks ago 7 2 0 0
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Fibrillarin/Nop1 perturbs RNA folding and assembly independently of liquid–liquid phase separation Abstract. The liquid–liquid phase-separated environment of the eukaryotic nucleolus is proposed to benefit ribosome assembly by chaperoning rRNA folding an

🚨New paper alert! Using single molecule TIRF microscopy, we show that Nop1 destabilizes RNA structure via transient, nonspecific interactions — until specific assembly of native ribosomal complexes takes over. Congrats, Wilson! 🎉 academic.oup.com/nar/article/...

2 weeks ago 13 4 0 0
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Metastable Folding of Bacillus subtilis glmS Ribozyme Modulates Turnover by RNase J1 Rapid turnover of glmS mRNA in Bacillus subtilis by 5′–3′ exoribonuclease RNase J is essential for feedback regulation of glucosamine-6-phosphate (Glc…

Our recent #singlemolecule study on RNase J decay is out! Congrats, Yuan! 🎉🎉 www.sciencedirect.com/science/arti...

3 months ago 4 1 0 0
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This bunch of RNA lovers knows how to unwind! Enjoying A-U-tumn and apple picking 🍎🍏

5 months ago 9 1 1 1
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Congratulations to Elise White @elisew00.bsky.social on winning a poster prize at the Regulating with RNA in Bacteria and Archaea meeting in Strasbourg! 🎉🎉

7 months ago 6 0 1 0
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Competition for Hfq drives kinetic selection of mRNA targets by Escherichia coli small noncoding RNAs | PNAS Small noncoding RNAs (sRNAs) regulate gene expression in Escherichia coli bacteria in response to diverse stimuli in the environment and the host. ...

Our new paper is out in PNAS! We show that competition for binding to the Hfq matchmaker disfavors mismatched sRNA-mRNA combinations while allowing matched sRNA-mRNAs to form stable pairs. Kudos to Jorjethe Roca and Yi-Lan Chen for their fantastic work on this problem! doi.org/10.1073/pnas...

9 months ago 7 2 0 1
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We had a great time at the #StandUpForScience rally in DC!

1 year ago 5 0 0 0

Thank you, Dina!! 😊😊

1 year ago 0 0 0 0
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Congratulations to Wilson on your NAR #Breakthrough paper!

1 year ago 15 4 0 1

Hello #RNA afficionados! We’re excited to join the science community on Bluesky!

1 year ago 5 1 0 0