Interferon-γ selectively promotes survival of alveolar progenitor cells in a human lung organoid model - The EMBO Journal Disease of the lung alveoli is frequently associated with acute or chronic inflammation. At present, there are no effective therapies to support regeneration of the alveolar epithelium, and ongoing in...

Interferon‑γ selectively promotes survival of alveolar progenitor cells in a human lung organoid model
– @antonelladost.bsky.social et al @thecleverslab.bsky.social describe a reductionist platform for discovering strategies to enhance alveolar regeneration
link.springer.com/article/10.1...

A human organoid model of alveolar regeneration reveals distinct epithelial responses to interferon-gamma Chronic obstructive pulmonary disease is characterized by inflammation and emphysema, leading to progressive alveolar destruction. Currently, no therapies effectively regenerate the alveolar epitheliu...

Manuscript alert! A human organoid model of alveolar regeneration reveals distinct epithelial responses to interferon-gamma. Thank you to all my co-authors and the Clevers lab @hansclevers.bsky.social

I would love to hear your thoughts on our findings!

doi.org/10.1101/2025...