Mitochondrial dysfunction triggers a maladaptive peroxisomal response driving lipid accumulation Mitochondria and peroxisomes communicate to maintain lipid homeostasis, but how the latter adjust to mitochondrial dysfunction remains unclear. Here, …

More organelle conversations!

www.sciencedirect.com/science/arti...

Looking forward to present at the Organelle Pharmacology conference in Oxford this April! This 2-day event highlights the paradigm shift toward treating diseases by precisely targeting the dysfunction of specific organelles. Registrations still available: my.bps.ac.uk/events/detai...

March 5th, not february. We sometimes bring the future to the present, but don't travel to the past.

We talk a lot about mitochondrial stress, but how about how do they keep themselves balanced? Good thing our speaker
@nieminm.bsky.social knows everything about that, and will tell all on the next MITOtalk. Usual time and place. See you there?

Very cool meeting on "Organelle Pharmacology: A new frontier for drug discovery" taking place this April in Oxford, UK.
@britpharmsoc.bsky.social

my.bps.ac.uk/events/detai...

Academic seminar reminder! BSRA members, details in your inbox. Non-member and want to attend? See here - bsra.org.uk/events/2026-...

We'll have
@nunoraimundo.bsky.social from @pennstateuniv.bsky.social
on Organelle communication in ageing and age-related diseases.

📅26th Feb
⏲️4pm (GMT)
📍online

Travelling to the future again. This thursday, we will be nosy and learn about mitochondria and their friendships.

Tomorrow. See you there?

Good Sunday, mitolovers. Here is the weekly curated issue of papers in #cancermetabolism and #mitochondrialbiology, with truly remarkable papers: lnkd.in/e7HDuVuU @biomednews.bsky.social #keepreading

"Attention is the rarest and purest form of generosity."-Simone Weil

Thinking about remodeling? Mitochondria do that too... and our speaker knows all about it.
This thursday, usual time and place.
See you there?

5 years of MITOtalks!

Feels like it was yesterday when @wanrooij20.bsky.social
and @nunoraimundo.bsky.social
opened the first MITOtalk to introduce
@frezzalab.bsky.social.

But it turns out FIVE YEARS have passed. That's 57 MITOtalks, 44 MITOchats, 6000+ followers.

Onwards and upwards!

The MITOscience of tomorrow is back.
Three short mitochats presented by
Débora Santos Rocha @deborasrocha.bsky.social ,
Valentin L’Hôte @valentinlhote.bsky.social and
Marijana Croon @marijanacroon.bsky.social
Visit mitotalks.org for zoom link details.
Will you time travel with us?

In case you overloaded mitochondria and peroxisomes during your holidays, know that they are talking about it... and our speaker Peter Kim overheard the conversation.
This thursday, usual time and place. See you there?

the MITOscience of tomorrow is back.

Last MitoTALK of 2025!

Ewa Warczak
@bomba_ewa

From Synthesis to Stability: Understanding the Lifecycle of Mitochondrial Proteins

Thursday, December 4, usual time.

See you there?
mitotalks.org

thanks Michael!

Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling | EMBO reports imageimageLoss of Batten disease-associated lysosomal protein CLN3 leads to DNA damage and activation of c-Abl-YAP1-dependent pro-apoptotic signaling which underlies increased apoptosis susceptibility...

New roles for lysosomes... and maybe new targets for Batten disease?

Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling | EMBO reports www.embopress.org/doi/full/10....

Membrane Contact Sites: Methodology, Biology & Pathology Intracellular organelles are connected through regions of close apposition known as membrane contact sites (MCS). The growing understanding of MCS’ biology and function has dramatically changed the t…

The 2025 @embo.org Contact Sites meeting was extraordinary. Congratulations to
Michelangelo Campanella and
Mélanie Paillard

meetings.embo.org/event/25-mem...

Marta Giacomello and I are already working to make the 2027 meeting memorable.

Keep in touch (like a contact site). It will be 🔥 🔥 🔥

The future is visiting again! We are seeking applicants for the 7th season of MITOchats. Deadline for submission is October 17th. Visit www.mitotalks.org for details or submit your application at forms.gle/5D6vWE92yYCi...

(2/2) And from January 2026 onwards:

Jan 08 Peter Kim
Feb 05 Robin Klemm
March 05 Natalie Niemi
April 02 Henry Higgs
May 07 Eija Pirinen
June 04 Heidi McBride

usual time and place. See you there?

Now that the summer season is over, it's time for some MITObusiness. (1/2)

Oct 02 Kostas Tokatlidis
Nov 06 Hiromi Sesaki
Dec 04 Ewa Bomba-Warczak

Happy 4th! 🇺🇸

2025 Midwest Metabolism Meeting Join us for 2025 Midwest Metabolism Meeting at Van Andel Institute Stay informed about exciting upcoming events and activities.

Sign up for midwest metabolism & Trimad joint meeting! Abstracts are due 9/2/25. The vast majority of talks will come from the abstracts - great opportunity for trainees! www.vai.org/event/2025-m...

MITOtalks and especially MITOchats have been playing with time travel. This week, instead of bringing the future over, we will get there faster: our speaker will tell us all about a mitochondrial progeria syndrome. Usual time and place.

Two mtDNA papers of ours in one PNAS issue:
#1 on the Y951N patient mutation of PolG, heroically spear-headed by Josefin Forslund
#2 revealing surprising dNTP imbalance & subsequent mtDNA depletion in RRM2B-deficient mice, a great collaboration with the Chabes lab
www.pnas.org/toc/pnas/122...

Retromer promotes the lysosomal turnover of mtDNA Lysosomal uptake of mtDNA controls mitochondrial quality.

Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵

www.science.org/doi/10.1126/...

Congratulations David!

clearly warrants further investigation.

Great chance for Canadian researchers to attend a great scientific meeting in Canada!

MITOtalks this week