All federal grants and loan disbursement paused by White House | CNN Politics The White House budget office has ordered a pause on all federal grants and loans, according to an internal memorandum sent Monday.

As a senior postdoc looking at professor positions I now have no idea how to move forward. The major discovery we made in the Bellen lab that Tau plays a protective role in glia needs further study to understand neurodegenerative diseases. I can't move forward without NIH standing.

And just like that, my new award from the @StateDept to help Pakistan grapple with air pollution and climate change is no more, thanks to this new administration

APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology - Molecular Neurodegeneration Background Apolipoprotein E ε4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD). A recent case report identified a rare variant in APOE, APOE3-R136S (Christchurch...

#APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology

So excited to finally be sharing this work! Congrats to my co-first author Kristine M. Tran and our amazing team @ucirvine.bsky.social 🎉

Causal modeling of gene effects from regulators to programs to traits: integration of genetic associations and Perturb-seq Genetic association studies provide a unique tool for identifying causal links from genes to human traits and diseases. However, it is challenging to determine the biological mechanisms underlying mos...

GWAS provides a unique tool in human biology as it can establish causal links from variants to trait.

But interpretation is difficult as most effects flow through (unobserved) gene regulatory networks. Can we gain insight by linking to modern Perturb-seq data?

www.biorxiv.org/content/10.1...

An integrated anatomical, functional and evolutionary view of the Drosophila olfactory system The Drosophila melanogaster olfactory system is one of the most intensively studied parts of the nervous system in any animal. Composed of ~60 independent olfactory neuron classes, with several associ...

New pre-print: an one-stop shop for everything you wanted to know about the fly olfactory system: www.biorxiv.org/content/10.1...