🗞Here is our editorial on advanced language models like ChaGPT's implications on patients' understanding of complex medical conditions like glomerular diseases. kidney.pub/KN1706-12
#kidneynews @dakidneydoc.bsky.social @asnpublications.bsky.social @kdjhaveri.bsky.social
#chatGPT #glomerulardisease

𝗜𝗦𝗡 𝗩𝗜𝗗𝗘𝗢 𝗔𝗕𝗦𝗧𝗥𝗔𝗖𝗧 𝗦𝗘𝗥𝗜𝗘𝗦: APOL1 genotype and HIV infection: 20 year outcomes for CKD, CVD and hypertension. 2025 from @kireports.bsky.social‬ www.kireports.org/ar...

#VideoAbstract by
‪@drsumanbehera.bsky.social‬ & @dakidneydoc.bsky.social‬

🚭#WHO created #WorldNoTobaccoDay (WNTD) in '87 to draw global attention 2 #tobacco epidemic -preventable death & disease caused by it
🌏2025 WNTD campaign:“Unmasking the Appeal: Exposing Industry Tactics on Tobacco & Nicotine Products” #TobaccoExposed
👩‍🏫 🚬 bskytorial by @deniiseam.bsky.social

NIH reorganization

No more NIDDK or NHLBI, combined into one institute

www.hhs.gov/sites/defaul...

h/t @jbrianbyrd.bsky.social

#MedSky

Hypoelectrolytemia. Low K, Mg Ca, Na and P.

Did you have to use more than the conservative measures for management?

A glimpse at the causes of an Acquired Bartter Defect too! #ECNeph

@myadla.bsky.social @dramiliflores.bsky.social @dilushiwijay.bsky.social @kajareeg.bsky.social @theisn.org @nephroseeker.medsky.social

👉 In vitro studies suggest that colonic Maxi – K channels are upregulated

👉 These are the same channels upregulated in CKD, enhancing gut excretion of potassium

👉 In ESRD, the colonic excretion of Potassium is 3-fold that of normal individuals
#ECNeph
@myadla.bsky.social @dramiliflores.bsky.social

Very interesting! I had couple of patients that got diagnosed as Ogilvie syndrome.

Sounds like pseudoobstruction... seen in patients with Ogilvie syndrome. Can also cause severe electrolyte dysfunction. But quite rare.. mostly diagnosed by GI before the nephrologists get to see them

Joining late to this party of electrolyte chaos.
Suman Behera from Toronto.

Novartis receives FDA accelerated approval for Vanrafia® (atrasentan), the first and only selective endothelin A receptor antagonist for proteinuria reduction in primary IgA nephropathy (IgAN) Vanrafia can be seamlessly added to supportive care in IgAN and used as a foundational therapy with no requirement for a REMS (Risk Evaluation Mitigation Strategy) program1 Phase III data showed Vanra...

After sparsentan, another ERA gets accelerated approval on the basis of albuminuria while GFR slope data is being collected

www.novartis.com/us-en/news/m...

@nejm.org paper here www.nejm.org/doi/full/10....

#NephSky

We check renin in all patients refd to the Ottawa hypertension clinic (also 24 hour urine for Na & K)

Renin phenotyping is useful - see data from @anandvaidya17.bsky.social in @ahajournals.bsky.social below

Figure 2

Figure 3

And sema for DM + PAD as well from #ACC25 in @thelancet.bsky.social

www.thelancet.com/journals/lan...

Glipination helps you walk 🚶🏽🚶🏻‍♀️🚶🏻‍♂️further

Happy to be able to share. Looking forward to learning from others as well.

a purple ninja with white bunny ears and a sword says thank you ALT: a purple ninja with white bunny ears and a sword says thank you

Thank you for engaging.

elvis presley is dancing in front of a group of men playing drums and guitars in a black and white photo . ALT: elvis presley is dancing in front of a group of men playing drums and guitars in a black and white photo .

Adios amigos. until later! Thanks..

a man with a beard and glasses is wearing a plaid shirt and smiling . ALT: a man with a beard and glasses is wearing a plaid shirt and smiling .

Did he have any worsening in kidney function after NET diagnosis? There are several other factors contributing to this as we discussed earlier.. keen to know more.

a man in a suit and tie is wearing sunglasses and says that is an excellent question . ALT: a man in a suit and tie is wearing sunglasses and says that is an excellent question .

Yes. scan had evidence of NET with mets to the liver. none to the kidneys though!

#ECNeph #ISNEducation
How hv your experiences & outcomes been in CgA nephropathy (Chromogranin A nephropathy/tubulopathy)? Would be great to hear about your patient outcomes. Add comments
@myadla.bsky.social‬ @drpriyajohn.bsky.social @dilushiwijay.bsky.social @theisn.org @arvindcanchi.bsky.social

#ECNeph
What have your experiences been like?
What was your treatment approach?
#ISNEducation #MedEd #Nephrology
@myadla.bsky.social‬ @drpriyajohn.bsky.social @dilushiwijay.bsky.social @theisn.org @arvindcanchi.bsky.social

#ECNeph #ISNEducation #CgA Limited documentation/publications
💉 For our patient, treating underlying NET improved kidney function
🔁Others have tried PLEX without much success
💊 Usually confused w/chemo or Rx toxicity😵‍💫
#Nephrology
@myadla.bsky.social‬ @dilushiwijay.bsky.social @theisn.org

Have any of you encounter Chromogranin A (CgA) Nephropathy/Tubulopathy? Not sure how to add a poll on BSKY!🤔
#ECNeph #ISNEducation
#MedEd #Nephrology
@myadla.bsky.social @drpriyajohn.bsky.social @drmarthagulati.bsky.social @dilushiwijay.bsky.social l @theisn.org @arvindcanchi.bsky.social

#ECNeph #ISNEducation
🚨 When can CgA give false positive results?
⚔️ Liver/kidney/heart failure, HTN, inflammatory ds like RA and IBD
#MedEd #Nephrology
@myadla.bsky.social‬ @drpriyajohn.bsky.social @dilushiwijay.bsky.social @theisn.org @arvindcanchi.bsky.social

@arvindcanchi.bsky.social thanks to you for creating this space!

#ECNeph #ISNEducation
✏️#CgA = #TumourMarker
📬 CgA positive ➡️ several #Neuroendocrine tumours
#MedEd #Nephrology
@myadla.bsky.social‬ @drpriyajohn.bsky.social @dilushiwijay.bsky.social @theisn.org @arvindcanchi.bsky.social

🗜️What is #ChromograninA ?
☠️HOW DOES IT ACT? ➡️ cytokines, degranulation, apoptosis... Lots of inflammatory processes⚡️
#ECNeph #ISNEducation
#MedEd #Nephrology
@myadla.bsky.social‬ @drpriyajohn.bsky.social @dilushiwijay.bsky.social @theisn.org @arvindcanchi.bsky.social

#ECNeph #ISNEducation
⚡️🔬 What else can cause Eosinophilic Intracytoplsmic Tubular inclusions/granules:
💪Rhabdomyolysis, 🦹malignancies, 😮‍💨chronic inflammation
👾Paneth cell like granules - ccRCC
🌸 HES
@myadla.bsky.social‬ @drpriyajohn.bsky.social @theisn.org @arvindcanchi.bsky.social

#ECNeph #ISNEducation
🔬 Eosinophilic Intracytoplasmic tubular inclusions/granules are also seen in: Light chain proximal tubulopathy, MM, Drug induced Fanconi synd.
#MedEd #Nephrology
@myadla.bsky.social‬ @drpriyajohn.bsky.social @dilushiwijay.bsky.social @theisn.org @arvindcanchi.bsky.social

#ECNeph #CgATubulopathy #CgANephropathy ➡️ Acute Tubular Injury.
🗜️#chromograninA expands/swells and collects within #ProximalTubules
🏗️ #CgA forms intraluminal #tubular #casts
@myadla.bsky.social‬ @drpriyajohn.bsky.social @dilushiwijay.bsky.social @theisn.org @arvindcanchi.bsky.social

Defining new reference intervals for serum free light chains in individuals with chronic kidney disease: Results of the iStopMM study - PubMed Serum free light chain (FLC) concentration is greatly affected by kidney function. Using a large prospective population-based cohort, we aimed to establish a reference interval for FLCs in persons wit...

pubmed.ncbi.nlm.nih.gov/36100605/

The FLC ratio is normal for that level of kidney function.. also has a h/o MGUS. #ECNeph