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Posts by Vikram Alva

Congratulations to Max Planck Research Group Leader Can Aztekin and his team on their new paper in @science.org. They have discovered how oxygen-sensing explains why amphibians regenerate limbs and mammals do not.
Read the full press release here: tinyurl.com/bsuwmek6

1 week ago 23 7 1 0

Our work on chromatin evolution in brown algae is finally out!

This is also my first "co-first author" paper!! I’m excited to share what we found 👇

3 weeks ago 55 20 3 1
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Open Positions -

Open postdoc position in my lab on HGT and interbacterial competition. We seek candidates with a PhD in microbiology (or related fields)+ strong 1st-author publications.
Curious, highly motivated, and dedicated team players ready to contribute fully are encouraged to apply. Details: tiny.cc/cz01101

3 weeks ago 49 60 0 2
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Chromatin organization in Asgard archaea: histones, SMC complexes, and the archaeal roots of eukaryotic chromatin The genomes of organisms across the tree of life are structurally and functionally organized into chromatin. In eukaryotes, within an organelle called…

New review in @cp-trendsgenetics.bsky.social on the fascinating world of chromatin organization in Asgard archaea. Very nice joint effort with @jvhooff.bsky.social www.sciencedirect.com/science/arti...

3 weeks ago 21 9 0 0
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How much protein diversity can Life on Earth actually generate?

With DIAMOND DeepClust, we show how billions of proteins across the tree of life can be clustered at low-identity for downstream analytics tasks.

📚Paper: www.nature.com/articles/s41...
💻Code: github.com/bbuchfink/di...

4 weeks ago 64 29 1 0

Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating).

A brief 🧵 (carried over from the old place)

1 month ago 380 152 16 15

Another paper on a topic we never worked on before: a new ribosomal hibernation!

Under the leadership of the super-postdoc Diorge, Davis Lab (ribo-cryoEM master), and @vikramalva.bsky.social (protein-evo whisperer), we identified AHA (not the song, but archaeal hibernation AMPKγ factor).

(1/2)

1 month ago 19 5 1 0
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Have you ever wondered 🤔... Does phenotypic variance respond to environmental perturbation? Does it have a genetic basis? Are mean and variance regulating loci exposed to different selection pressures? These and more questions are explored in our new preprint 🔥

www.biorxiv.org/content/10.6...

1 month ago 88 49 2 4

Very cool work led by @diorgeps.bsky.social from the labs of @archaeon-alex.bsky.social & Joey Davis (MIT)!

They solved the Haloferax volcanii ribosome and characterize AHA, a conserved archaeal hibernation factor.

With several recent related preprints, it’s an exciting moment for the field!

1 month ago 12 4 0 0
Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Medical Research Council Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳

mrc.tal.net/vx/mobile-0/...

2 months ago 83 106 1 3
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Tenure-Track Assistant Professor / Associate Professor in Bioinformatics and/or Computational Biology at Aarhus University, Denmark - Vacancy at Aarhus University Vacancy at Department of Molecular Biology and Genetics - BiRC - Bioinformatics Research Center, Aarhus University

Aarhus University is seeking a Tenure-Track Assistant/Associate Professor in Bioinformatics/Co… nat.au.dk/en/about-the-faculty/vac... #job

2 months ago 19 34 0 1
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📣 New paper alert! This is a story of molecular tricks that let spirochetes (spiral-shaped bacteria) drill through tissue. www.biorxiv.org/content/10.6...

2 months ago 30 9 1 2
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Germline fate determination by a single ARGONAUTE protein in Ectocarpus | PNAS ARGONAUTE (AGO) proteins are a highly conserved family of RNA-binding proteins that play central roles in gene regulation and developmental process...

One protein. One pathway. A whole germline fate.

New paper from my postdoc @mpi-bio-fml.bsky.social out in PNAS:
Germline fate determination by a single ARGONAUTE protein in Ectocarpus www.pnas.org/doi/10.1073/...

2 months ago 51 26 1 1
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Research Group Leader Do you want to lead groundbreaking research in computational biology? Join us at EMBL-EBI! EMBL's European Bioinformatics Institute (EMBL-EBI) is seeking talented and highly-motivated scientists to jo...

We are hiring for group leaders again — EBI is a great place to start your research group!

embl.wd103.myworkdayjobs.com/EMBL/job/Hin...

2 months ago 66 88 0 2
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From fibril to framework: P. abyssi AbpX illuminates a calcium-responsive family of microbial biomatrix proteins that form thermostable hydrogels Evolutionary pressure on microbial communities propagating under extreme environmental conditions often results in unique structural adaptations to promote cell survival. Here, we report an investigat...

New manuscript alert. Turns out that calcium ion coordination may be a more common mechanism than we initially expected to trigger polymerization of extracellular filaments. @mikesleutel.bsky.social @vikramalva.bsky.social

www.biorxiv.org/content/10.6...

3 months ago 7 5 1 1

Excited to be at #SMBE2026 in Copenhagen! Don’t miss Symposium #17: “Unicellular organisms in major evolutionary transitions.” Registration is now open!

#protistsonsky

4 months ago 16 6 0 0

📝 Abstract deadline: Tuesday, Feb 3, 2026.
Let’s fill #SMBE2026 with #protistsonSky love!

3 months ago 4 1 0 0

The real drama of life happened "backstage" in the unicellular world. 🎭🧬 #protistsonSky
Our postdoc Vika Shabardina is co-organizing this symposium with Annia (@ankarn.bsky.social). Two brilliant minds leading the evocell way!
Plus, a talk by @vikramalva.bsky.social. 👇

3 months ago 17 5 1 0

Led by Yimin Hu, with key contributions from
@samuelschwab.bsky.social, @kyq21.bsky.social 21.bsky.social and Yunsen Zhang, and in collaboration with Marcus Hartmann, @damelab.bsky.social and Birte Hernández-Álvarez.

@mpi-bio-fml.bsky.social

4 months ago 3 0 0 0
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Happy to share that our work on HLp, a bacterial histone from Leptospira perolatii, is now published in Nature Communications 🎉

In this study, we show that HLp forms stable tetramers that wrap ~60 bp of DNA, revealing a distinct histone–DNA organization in bacteria.

www.nature.com/articles/s41...

4 months ago 54 16 2 1
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SMBE2026 Symposium 17 | Unicellular organisms in major evolutionary transitions

Organisers
- Victoria Shabardina — Institute of Evolutionary Biology (UPF-CSIC), Barcelona, Spain (Female)
- Anna Karnkowska — Institute of Evolutionary Biology, Faculty of Biology, University of Warsaw, Warsaw, Poland (Female)

Invited Speaker
- Vikram Alva — Max Planck Institute of Biology, Tuebingen, Germany (Male)

SMBE2026 Symposium 17 | Unicellular organisms in major evolutionary transitions Organisers - Victoria Shabardina — Institute of Evolutionary Biology (UPF-CSIC), Barcelona, Spain (Female) - Anna Karnkowska — Institute of Evolutionary Biology, Faculty of Biology, University of Warsaw, Warsaw, Poland (Female) Invited Speaker - Vikram Alva — Max Planck Institute of Biology, Tuebingen, Germany (Male)

Organisers
- Victoria Shabardina | @ibe-barcelona.bsky.social
- @ankarn.bsky.social | University of Warsaw

Invited Speaker
- @vikramalva.bsky.social | @mpi-bio-fml.bsky.social

4 months ago 8 4 0 2
SMBE2026 Symposium 17 | Unicellular organisms in major evolutionary transitions

SMBE2026 Symposium 17 | Unicellular organisms in major evolutionary transitions

SMBE2026 Symposium 17 | Unicellular organisms in major evolutionary transitions

📨 Abstract submission
smbe2026.org/abstracts

📋 Programme details
smbe2026.org/programme

#SMBE2026

4 months ago 6 3 1 0
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GenBio DTP Optional supporting text

I’m excited to announce that I will be starting my research group on computational enzyme design at the Generative Biology Institute, Oxford, UK (@eitoxford.bsky.social)! PhD applications are open, deadline is Jan 8th (www.chem.ox.ac.uk/genbio-dtp). Email kiarash.jamali@eit.org with any questions!

4 months ago 61 14 9 5
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Ending my PhD with a bang:
Face-to-face histones are important organizers of archaeal chromatin alongside classical histones.

www.biorxiv.org/content/10.6...

4 months ago 20 4 1 1

Thank you, Daniela, @danielabarilla.bsky.social, for a wonderful commentary! 🤗🤗 More spotlight on the Asgards and their chromatin! ❤️ #archaea #chromatin

5 months ago 21 7 0 0
Introduction to microbial surface layers (S-layers)
Introduction to microbial surface layers (S-layers) YouTube video by MRC Laboratory of Molecular Biology

Also see the associated primer video on S-layers made by the @mrclmb.bsky.social Visual Aids department Konstantinos Alexandrou and Shraddha Nayak!

www.youtube.com/watch?v=fgSf...

5 months ago 9 1 0 1

Pleased to share our review on S-layers with @bupbuse.bsky.social, Andriko von Kügelgen, and @tbharat-lab.bsky.social, where we explore recent advances and argue that deeper insight into S-layers is key to deciphering microbial interactions and community organization. @mpi-bio-fml.bsky.social

5 months ago 15 9 0 0
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We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.

5 months ago 162 48 8 4