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Posts by Nikolas Stefanidis

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Holy. Shit. This is Reid Wiseman's video he took with his iPhone while at the moon 🌙

2 days ago 15334 2936 396 272
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Witness breathtaking drone footage capturing the fiery heart of a volcanic eruption. A new era of vulcanology is here, revealing nature's power like never before.

4 days ago 2258 388 92 40

🎉🎉🎉🎉🎉🎉🎉

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How do you build the posterior end of a body? 🧫🔬🧬 I am excited to share that my PhD work on the generation of hindlimb and genital progenitors from human pluripotent stem cells is now available on BioRxiv!
🔗 www.biorxiv.org/content/10.6...

4 days ago 8 4 2 2
Blocking out earth shuttering unpublished data considering my fully penetrant bluesky presence

Blocking out earth shuttering unpublished data considering my fully penetrant bluesky presence

School poster prize :D

School poster prize :D

Mama I won a poster prize 🏆🎉

5 days ago 4 0 0 0
The solar eclipse captured from a camera mounted on one of the Orion spacecraft’s solar array wings during the Artemis II crew’s flyby of the Moon’s far side. The science community is investigating whether the glow around the Moon is from zodiacal light -- interstellar dust that’s reflecting sunlight -- the solar corona, or a combination of the two. Unlike minutes-long eclipses as viewed from Earth, the Artemis II crew saw the Sun hide behind the Moon for nearly an hour. In this image, Venus can be spotted on the left, and Saturn on the right of the Moon. Credit: NASA

The solar eclipse captured from a camera mounted on one of the Orion spacecraft’s solar array wings during the Artemis II crew’s flyby of the Moon’s far side. The science community is investigating whether the glow around the Moon is from zodiacal light -- interstellar dust that’s reflecting sunlight -- the solar corona, or a combination of the two. Unlike minutes-long eclipses as viewed from Earth, the Artemis II crew saw the Sun hide behind the Moon for nearly an hour. In this image, Venus can be spotted on the left, and Saturn on the right of the Moon. Credit: NASA

Orion and solar eclipse: new, fascinating image posted on NASA Johnson's flickr account, captured by a GoPro camera mounted on one of the Orion spacecraft’s solar array wings. Venus can be spotted on the left, and Saturn on the right of the Moon.

flic.kr/p/2s7wkRo #Artemis 🧪🔭

1 week ago 152 46 2 3
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Happy #fluorescencefriday (and start of vacation!) to all those who are celebrating
Lifeact-labeled epidermal stem cells closing a wound after in vivo adult zebrafish skin injury

1 week ago 124 30 5 0
NASA’s Orion spacecraft is seen as the agency’s Landing and Recovery team, along with U.S. Navy personnel work to recover the spacecraft into the well deck of USS John P. Murtha in the Pacific Ocean off the coast of California, Saturday, April 11, 2026. NASA’s Artemis II mission, which took NASA astronauts Reid Wiseman, commander; Victor Glover, pilot; Christina Koch, mission specialist; and CSA (Canadian Space Agency) astronaut Jeremy Hansen, mission specialist on a nearly 10-day journey around the Moon and back to Earth, splashed down at 5:07 p.m. PDT (8:07 p.m. EDT). Photo Credit: (NASA/Joel Kowsky)

NASA’s Orion spacecraft is seen as the agency’s Landing and Recovery team, along with U.S. Navy personnel work to recover the spacecraft into the well deck of USS John P. Murtha in the Pacific Ocean off the coast of California, Saturday, April 11, 2026. NASA’s Artemis II mission, which took NASA astronauts Reid Wiseman, commander; Victor Glover, pilot; Christina Koch, mission specialist; and CSA (Canadian Space Agency) astronaut Jeremy Hansen, mission specialist on a nearly 10-day journey around the Moon and back to Earth, splashed down at 5:07 p.m. PDT (8:07 p.m. EDT). Photo Credit: (NASA/Joel Kowsky)

NASA’s Orion spacecraft is seen as the agency’s Landing and Recovery team, along with U.S. Navy personnel work to recover the spacecraft into the well deck of USS John P. Murtha in the Pacific Ocean off the coast of California, Saturday, April 11, 2026. NASA’s Artemis II mission, which took NASA astronauts Reid Wiseman, commander; Victor Glover, pilot; Christina Koch, mission specialist; and CSA (Canadian Space Agency) astronaut Jeremy Hansen, mission specialist on a nearly 10-day journey around the Moon and back to Earth, splashed down at 5:07 p.m. PDT (8:07 p.m. EDT). Photo Credit: (NASA/Joel Kowsky)

NASA’s Orion spacecraft is seen as the agency’s Landing and Recovery team, along with U.S. Navy personnel work to recover the spacecraft into the well deck of USS John P. Murtha in the Pacific Ocean off the coast of California, Saturday, April 11, 2026. NASA’s Artemis II mission, which took NASA astronauts Reid Wiseman, commander; Victor Glover, pilot; Christina Koch, mission specialist; and CSA (Canadian Space Agency) astronaut Jeremy Hansen, mission specialist on a nearly 10-day journey around the Moon and back to Earth, splashed down at 5:07 p.m. PDT (8:07 p.m. EDT). Photo Credit: (NASA/Joel Kowsky)

NASA’s Orion spacecraft is seen as the agency’s Landing and Recovery team, along with U.S. Navy personnel work to recover the spacecraft into the well deck of USS John P. Murtha in the Pacific Ocean off the coast of California, Saturday, April 11, 2026. NASA’s Artemis II mission, which took NASA astronauts Reid Wiseman, commander; Victor Glover, pilot; Christina Koch, mission specialist; and CSA (Canadian Space Agency) astronaut Jeremy Hansen, mission specialist on a nearly 10-day journey around the Moon and back to Earth, splashed down at 5:07 p.m. PDT (8:07 p.m. EDT). Photo Credit: (NASA/Joel Kowsky)

NASA’s Orion spacecraft is seen as the agency’s Landing and Recovery team, along with U.S. Navy personnel work to recover the spacecraft into the well deck of USS John P. Murtha in the Pacific Ocean off the coast of California, Saturday, April 11, 2026. NASA’s Artemis II mission, which took NASA astronauts Reid Wiseman, commander; Victor Glover, pilot; Christina Koch, mission specialist; and CSA (Canadian Space Agency) astronaut Jeremy Hansen, mission specialist on a nearly 10-day journey around the Moon and back to Earth, splashed down at 5:07 p.m. PDT (8:07 p.m. EDT). Photo Credit: (NASA/Joel Kowsky)

NASA’s Orion spacecraft is seen as the agency’s Landing and Recovery team, along with U.S. Navy personnel work to recover the spacecraft into the well deck of USS John P. Murtha in the Pacific Ocean off the coast of California, Saturday, April 11, 2026. NASA’s Artemis II mission, which took NASA astronauts Reid Wiseman, commander; Victor Glover, pilot; Christina Koch, mission specialist; and CSA (Canadian Space Agency) astronaut Jeremy Hansen, mission specialist on a nearly 10-day journey around the Moon and back to Earth, splashed down at 5:07 p.m. PDT (8:07 p.m. EDT). Photo Credit: (NASA/Joel Kowsky)

NASA’s Orion spacecraft is seen as the agency’s Landing and Recovery team, along with U.S. Navy personnel work to recover the spacecraft into the well deck of USS John P. Murtha in the Pacific Ocean off the coast of California, Saturday, April 11, 2026. NASA’s Artemis II mission, which took NASA astronauts Reid Wiseman, commander; Victor Glover, pilot; Christina Koch, mission specialist; and CSA (Canadian Space Agency) astronaut Jeremy Hansen, mission specialist on a nearly 10-day journey around the Moon and back to Earth, splashed down at 5:07 p.m. PDT (8:07 p.m. EDT). Photo Credit: (NASA/Joel Kowsky)

Hero spacecraft inside the well deck of the USS John P. Murtha

www.flickr.com/photos/nasah...

#Artemis 🧪🔭

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The world's first view of Earth taken by a spacecraft from the vicinity of the Moon. The photo was transmitted to Earth by the United States Lunar Orbiter I and received at the NASA tracking station at Robledo De Chavela near Madrid, Spain. This crescent of the Earth was photographed August 23, 1966 at 16:35 GMT when the spacecraft was on its 16th orbit and just about to pass behind the Moon. Credit: NASA.

The world's first view of Earth taken by a spacecraft from the vicinity of the Moon. The photo was transmitted to Earth by the United States Lunar Orbiter I and received at the NASA tracking station at Robledo De Chavela near Madrid, Spain. This crescent of the Earth was photographed August 23, 1966 at 16:35 GMT when the spacecraft was on its 16th orbit and just about to pass behind the Moon. Credit: NASA.

Earthset captured through the Orion spacecraft window at 6:41 p.m. EDT, April 6, 2026, during the Artemis II crew’s flyby of the Moon. A muted blue Earth with bright white clouds sets behind the cratered lunar surface. The dark portion of Earth is experiencing nighttime. On Earth’s day side, swirling clouds are visible over the Australia and Oceania region. In the foreground, Ohm crater has terraced edges and a flat floor interrupted by central peaks—formed when the surface rebounded upward during the impact that created the crater. Image Credit: NASA.

Earthset captured through the Orion spacecraft window at 6:41 p.m. EDT, April 6, 2026, during the Artemis II crew’s flyby of the Moon. A muted blue Earth with bright white clouds sets behind the cratered lunar surface. The dark portion of Earth is experiencing nighttime. On Earth’s day side, swirling clouds are visible over the Australia and Oceania region. In the foreground, Ohm crater has terraced edges and a flat floor interrupted by central peaks—formed when the surface rebounded upward during the impact that created the crater. Image Credit: NASA.

How it started, how it's going

Left: Lunar Orbiter I, 1966
Right: Artemis II, 2026

flic.kr/p/8Grtp2
flic.kr/p/2s68RXM

#Artemis 🧪🔭

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NASA’s Orion spacecraft captures the Moon and the Earth in one frame during the Artemis II crew’s deep space journey at 6:42 p.m. ET on the sixth day of the mission. The right side of NASA’s Orion spacecraft is seen lit up by the Sun. A waxing crescent Moon is visible behind it. And then, a crescent Earth, tiny compared to the Moon, is about to set below the Moon’s horizon on the right. Credit: NASA

NASA’s Orion spacecraft captures the Moon and the Earth in one frame during the Artemis II crew’s deep space journey at 6:42 p.m. ET on the sixth day of the mission. The right side of NASA’s Orion spacecraft is seen lit up by the Sun. A waxing crescent Moon is visible behind it. And then, a crescent Earth, tiny compared to the Moon, is about to set below the Moon’s horizon on the right. Credit: NASA

Earthset captured through the Orion spacecraft window at 6:41 p.m. EDT, April 6, 2026, during the Artemis II crew’s flyby of the Moon. A muted blue Earth with bright white clouds sets behind the cratered lunar surface. The dark portion of Earth is experiencing nighttime. On Earth’s day side, swirling clouds are visible over the Australia and Oceania region. In the foreground, Ohm crater has terraced edges and a flat floor interrupted by central peaks—formed when the surface rebounded upward during the impact that created the crater.

Image Credit: NASA

Earthset captured through the Orion spacecraft window at 6:41 p.m. EDT, April 6, 2026, during the Artemis II crew’s flyby of the Moon. A muted blue Earth with bright white clouds sets behind the cratered lunar surface. The dark portion of Earth is experiencing nighttime. On Earth’s day side, swirling clouds are visible over the Australia and Oceania region. In the foreground, Ohm crater has terraced edges and a flat floor interrupted by central peaks—formed when the surface rebounded upward during the impact that created the crater. Image Credit: NASA

The Moon, seen here backlit by the Sun during a solar eclipse on April 6, 2026, is photographed by one of the cameras on the Orion spacecraft’s solar array wings. Orion is visible in the foreground on the left. Earth is reflecting sunlight at the left edge of the Moon, which is slightly brighter than the rest of the disk. The bright spot visible just below the Moon’s bottom right edge is Saturn. Beyond that, the bright spot at the right edge of the image is Mars. Credit: NASA

The Moon, seen here backlit by the Sun during a solar eclipse on April 6, 2026, is photographed by one of the cameras on the Orion spacecraft’s solar array wings. Orion is visible in the foreground on the left. Earth is reflecting sunlight at the left edge of the Moon, which is slightly brighter than the rest of the disk. The bright spot visible just below the Moon’s bottom right edge is Saturn. Beyond that, the bright spot at the right edge of the image is Mars. Credit: NASA

As the Artemis II crew flew over the terminator, the astronauts described this boundary between day and night as "anything but a straight line." Crater rims along the terminator stand out as "islands" in the night. Giant chains of craters emanating from the 3.7-billion-year-old Orientale basin can be seen scouring the surface, stretching almost to the terminator. This tells a geologic story: these crater chains produced by the Orientale impact event mar the surface of the relatively flat Hertzsprung Basin (center of this image), which means that Hertzsprung Basin must be even older than Orientale!

Image Credit: NASA

As the Artemis II crew flew over the terminator, the astronauts described this boundary between day and night as "anything but a straight line." Crater rims along the terminator stand out as "islands" in the night. Giant chains of craters emanating from the 3.7-billion-year-old Orientale basin can be seen scouring the surface, stretching almost to the terminator. This tells a geologic story: these crater chains produced by the Orientale impact event mar the surface of the relatively flat Hertzsprung Basin (center of this image), which means that Hertzsprung Basin must be even older than Orientale! Image Credit: NASA

Artemis II Lunar Flyby gallery

www.nasa.gov/gallery/luna...

#Artemis 🧪🔭

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A crescent Earth far away in the darkness with the frame of a window of the Orion Integrity spacecraft to the left. This image was taken by an Artemis II crew member on the fifth day of the mission, using a Nikon D5 camera.

A crescent Earth far away in the darkness with the frame of a window of the Orion Integrity spacecraft to the left. This image was taken by an Artemis II crew member on the fifth day of the mission, using a Nikon D5 camera.

Peering out one of the four windows near the display console of the Orion spacecraft, the Earth is illuminated by the blackness of space and grows smaller as the crew journeys closer to the Moon. Credit: NASA.

flic.kr/p/2s5Vzbd #Artemis 🧪🔭

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2026 Waddington Medal Winner - James Briscoe - BSDB - British Society for Developmental Biology We are very pleased to announce that this year’s Waddington medal winner is James Briscoe. His fundamental discoveries have helped shape our understanding of of how morphogens work, and he has played ...

Huge congratulations to James Briscoe @jamesbriscoe.bsky.social for receiving the 2026 BSDB Waddington Medal, recognising an extraordinary career of discovery, mentorship, and leadership in developmental biology.

bsdb.org/2026/03/24/2...

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Our #CellLineOfTheWeek is beta-actin - illuminating actin filaments! 🧫

Our entire catalog of stem cell lines & plasmids are available to researchers for just the cost of shipping to reduce the barriers to discovery

📦 Distributed by @Coriell_Science and @Addgene

1 month ago 8 3 0 0
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Transitions in development – an interview with Aydan Bulut-Karslioglu Aydan Bulut-Karslioglu is a Group Leader at the Max Planck Institute for Molecular Genetics, Germany, where her research focuses on the epigenetic and metabolic mechanisms regulating embryonic develop...

Many animals adjust or pause development in response to environmental conditions to maximise survival. To understand this potential, called diapause, @bulutkarslioglu.bsky.social induces a diapause-like state in mice & embryonic stem cells. #gfe2026

@dev-journal.bsky.social interview with Aydan⤵️

1 month ago 11 4 1 0
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‘Muscle Brain’ literally obscures sight.

Not protective. Just limiting. Not shielding vulnerability. Just preventing clarity.

‘Muscle’… not as armor.
But as blindfold.

What happens when stubborn clinging to illusions of brute force there’s nothing but override vision

Britt-Ingrid Persson 🇸🇪

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HES1 oscillations are required for cell cycle reentry in oestrogen receptor–positive breast cancer cells | PNAS Long-term recurrence in breast cancer is driven by reactivation of dormant disseminated tumor cells (DTCs) and remains a major clinical challenge, ...

Dynamics, dynamics, dynamics! We asked how ER+ breast cancer cells transition from dormancy to reactivation. Inspired by developmental biology, we show that HES1 protein oscillations change during this shift — and that disrupting these dynamics prevents reactivation. www.pnas.org/doi/10.1073/...

1 month ago 3 1 1 1
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The greatest risk of AI in higher education isn't cheating—it's the erosion of learning itself Public debate about artificial intelligence in higher education has largely orbited a familiar worry: cheating. Will students use chatbots to write essays? Can instructors tell? Should universities ba...

“Cognitive psychology has shown that students grow intellectually through doing the work of drafting, revising, failing, trying again, grappling with confusion, and revising weak arguments. This is the work of learning how to learn”
phys.org/news/2026-02...

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Cover: Immunofluorescence staining of phosphorylated FGFR1 (magenta), TBXT (yellow) and β-catenin (cyan) in 2D human gastruloids. The spatial pattern of phosphorylated FGFR1 matches ERK activity observed during primitive streak-like differentiation. See Research Article by Jo, Liu et al. (dev205459).

Cover: Immunofluorescence staining of phosphorylated FGFR1 (magenta), TBXT (yellow) and β-catenin (cyan) in 2D human gastruloids. The spatial pattern of phosphorylated FGFR1 matches ERK activity observed during primitive streak-like differentiation. See Research Article by Jo, Liu et al. (dev205459).

Issue 3 is complete!

On the cover: Immunofluorescence staining of phosphorylated FGFR1 (magenta), TBXT (yellow) and β-catenin (cyan) in 2D human gastruloids.

See the Research Article by Idse Heemskerk and colleagues (@heemskerklab.bsky.social) here: doi.org/10.1242/dev....

2 months ago 12 3 1 0
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Developmental origins of paediatric cancer symposium A one-day event showcasing the latest cutting-edge research on the modelling, biology and treatment of paediatric cancers in the context of their developmental origins.

2 weeks to go until the registration/abstract submission deadline for our @cclguk.bsky.social @dmmjournal.bsky.social symposium on the developmental origins of paediatric cancers at the @crick.ac.uk this June. Great speaker line up and slots for short talks: www.cclg.org.uk/information-...

2 months ago 5 3 0 1
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Not something you see in textbooks very often: tripolar mitosis.

2 months ago 1572 274 49 22
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An intracellular meteor shower. EB3 comets tracking growing microtubule plus-ends in a cultured cell.

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Friends! I am so happy to share our new preprint!

Hydrogen peroxide has been the most common reactive chemical threat to life forms since the Great Oxygenation Event 2.5 billion years ago.

How do animals like C. elegans sense it fast and escape?

www.biorxiv.org/content/10.6...

Thread 1/

2 months ago 81 31 7 3
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The lab turned 10 this month, what better way to celebrate than with an amazing cake from @faycooper.bsky.social! I feel lucky to have worked alongside so many talented students, postdocs, and colleagues here in Sheffield over the years.

2 months ago 24 1 3 0
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The world feels rough right now

So please enjoy this shrimp, filmed off Cozumel, Mexico. It may be a larval reef shrimp, but we don’t know what species or how long it lives or what it eats. The world is still full of wonder and beauty and mystery.

🎥 @pedrovalenciam scuba diver on Insta

3 months ago 2088 728 44 56

Another fascinating - and totally serendipitous - example of how human biological sex isn't always binary, despite executive orders that it is. In this case an XX/XY mosaic individual was a fertile female. Other XX/XY mosaics can be phenotypically male.

3 months ago 8 6 3 0
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⏰ Deadline Approaching! ⏰
📅 15 January 2026

Under two weeks to apply for our fully funded PhD project “Engineering an in vitro human embryo implantation platform to study pathologies arising in early pregnancy” at @sheffielduni.bsky.social. #development #endometrium #materialsscience

3 months ago 1 1 0 0
Figure 4: Fusion mutants fail to acquire the L1 epidermal transcriptome. (A) Normal (WT) developmental trajectories of upregulated (red) or downregulated (blue) genes in eff-1 mutants. Shaded region, 95% confidence interval. Dashed line, approximate hatching time of 800 min. (B) Genes were binned using a linear regression of modENCODE data to determine transcripts that went up (green), down (purple) or stayed consistent (gray) across WT development. Average log2-transformed fold change RNA-seq data from eff-1(P37Stop) for each category of genes are shown. Error bars show s.e.m.; Mann–Whitney U-test, ****P<0.00001. (C) Heatmap of z-score–normalized DEG expression for genes identified as ELT-3-regulated from the TF2DNA dataset (Pujato et al., 2014). (D) Schematic of WT and eff-1 mutant gene expression profiles across development.

Figure 4: Fusion mutants fail to acquire the L1 epidermal transcriptome. (A) Normal (WT) developmental trajectories of upregulated (red) or downregulated (blue) genes in eff-1 mutants. Shaded region, 95% confidence interval. Dashed line, approximate hatching time of 800 min. (B) Genes were binned using a linear regression of modENCODE data to determine transcripts that went up (green), down (purple) or stayed consistent (gray) across WT development. Average log2-transformed fold change RNA-seq data from eff-1(P37Stop) for each category of genes are shown. Error bars show s.e.m.; Mann–Whitney U-test, ****P<0.00001. (C) Heatmap of z-score–normalized DEG expression for genes identified as ELT-3-regulated from the TF2DNA dataset (Pujato et al., 2014). (D) Schematic of WT and eff-1 mutant gene expression profiles across development.

Fuse it or lose it: cell fusion drives developmental progression

This Research Highlight showcases work by Owen Funk, Daniel Levy and David Fay:

journals.biologists.com/dev/article/...

3 months ago 7 1 1 0
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Wow

4 months ago 1 0 0 0
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This movie shows lysosomes (orange) and keratin (gray) in a cultured cell over 10 minutes.

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What is the future of intelligence? The answer could lie in the story of its evolution The advent of artificial intelligence might be just the latest stage in a guiding biological process that has produced ever more complex, mutually dependent organisms over the history of life.

Super interesting read about the connections of human and AI evolution 🧬

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What is the future of intelligence? The answer could lie in the story of its evolution www.nature.com/articles/d41...

4 months ago 0 0 0 0