Human genetic variation associates with infection by derived Ugandan M. tuberculosis lineage This study examined host genetic determinants of infection with the L4-Uganda tuberculosis lineage using a genome-wide association study. Supportive analys

Our latest study supporting role of host pathogen interaction in susceptibility to tuberculosis, not just disease severity

Human genetic variation associates with infection by derived Ugandan M. tuberculosis lineage academic.oup.com/jid/article/...

Disrupted lipid homeostasis as a pathogenic mechanism in ABCA7‐associated Alzheimer's disease risk INTRODUCTION ABCA7 (ATP binding cassette subfamily A member 7) encodes a lipid transporter associated with increasing risk for Alzheimer's disease (AD). A 44-base pair deletion in ABCA7 (rs142076058...

Disrupted lipid homeostasis as a pathogenic mechanism in ABCA7‐associated Alzheimer's disease risk - Nam - 2026 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

I am not an average but so much about me is decided by averages.

Often the most obvious ideas in retrospect is the most important.

Dissecting Alzheimer's disease heritability across populations INTRODUCTION Late-onset Alzheimer's disease (LOAD) is highly heritable; however, its estimated incidence across populations remains unclear. METHODS We computed family-based heritability leveragin...

Variation across populations in heritability of Alzheimer's Disease

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

I like chaos for discovery but rigor for validation

Me, too

When I was a student we called our PIs supervisors but they were often more like mentors. Now we call PIs mentors but they are more like supervisors. It's all in the marketing isn't it?

I've lost many university emails - never made a dent

Professor breaks down how a PhD differs from a master's degree in layman's terms A college professor explained how a master’s degree differs from a PhD, and people found her explanation helpful and accessible.

I always try to tell new PhD students many of these things but still they think about classes and grades. And students with a masers can be even more intransigent as have couple more years of same mindset. Of course it is one person's point of view

www.upworthy.com/professor-ex...

The Misuses of the University - Public Books Have the funds that might have trained the next generation of scholars at the nation’s first research university have been blown on ostentatious new buildings?

A depressing picture of the academy in modernity. If ever there was a time for faculty to assert shared governance it is now. If not too late

www.publicbooks.org/the-misuses-...

Deviations from additivity in APOE4-mediated late-onset Alzheimer’s disease risk across races and ethnicities - Human Genetics Human Genetics - APOE’s ε4 haplotype (APOE4) is late onset Alzheimer’s disease’s (LOAD) strongest genetic risk factor. Therefore, accurately modeling APOE4’s effect is...

Additive genetic models are not always the best and differences seem to exist between populations

stlink.springer.com/article/10.1007/s00439-0...

There is a difference between sophistry and science. I wish leaders of our govt agencies overseeing research would take it seriously

Where do we go from here?

So who defines unsafe?

Could only get through half of this - so many self-inflicted wounds that we will pay for - for many years to come and tracing it back to current policies will be glossed over.

Opinion | A.I. Companies Are Eating Higher Education

www.nytimes.com/2026/02/12/o...

Yep, loved it

Text in paper: "Both HEU and HUU cohorts were recruited from the same hospital during the same enrollment period, with matching criteria detailed in Table S1"
Reviewer: "It is unclear how the HUU was selected – is this the same hospital/region"
Becoming the norm - maybe unreviewed papers are better?

Yep. Fun, fun

In modern science education we too often we learn how to do things not how to question what we do. As scientists we too often are judged by how much we do, not what we do. This is a perverse system of metrics that slows development of knowledge

"It’s one of the real black marks on the history of higher education that an entire industry that’s supposedly populated by the best minds in the country—theoretical physicists, writers, critics—is bamboozled by a third-rate news magazine"
Leon Botstein on college rankings, The New Yorker 2014

Has anyone else had a paper on medrxiv been sent out for review after a predatory journal reached out? We did not agree to submit it as it is under revision elsewhere, but we were sent an unsolicited review from the aforementioned journal. Very unethical!!

Opposing effects of SARS-CoV-2/COVID-19 infection and recombinant zoster vaccination on the risk of late-onset Alzheimer disease Abstract Importance More than half a decade since the emergence of SAR-CoV-2, its broader sequelae are still poorly understood. Initial data indicate viral infections such as SARS-CoV-2 and herpes zos...

www.medrxiv.org/content/10.6...

Is it time to re-read "On Bullsh*t" by Harry Frankfurt. The world he pictures has only gotten bleaker

Of course - just pushing the extreme

Is AI the only thing we all should ve working on if we want to preserve humanity

If we are concerned about future of humanity maybe AI research and how it plays out is all we should be working on, if we can

AI models collapse when trained on recursively generated data - Nature  Analysis shows that indiscriminately training generative artificial intelligence on real and generated content, usually done by scraping data from the Internet, can lead to a collapse in th...

Ooops
www.nature.com/articles/s41...

The best you've posted to date!