Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders Borges, González-Blanco, Arigela, et al. report new missense mutations in the PRC1 genes RNF2 and RING1 in individuals with neurodevelopmental disorders. Functional dissection of a deleterious variant...

Very excited to share our new Molecular Cell paper on missense mutations in Polycomb genes and how they can disrupt chromatin regulation to drive neurodevelopmental disorders. A huge thank you to everyone involved, and to our amazing collaborators!
www.cell.com/molecular-ce...

Thanks Daphne!!!!

Thank you KJ! See you very soon!

Thanks Rob!

Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders Borges, González-Blanco, Arigela, et al. report new missense mutations in the PRC1 genes RNF2 and RING1 in individuals with neurodevelopmental disorders. Functional dissection of a deleterious variant...

Very excited to share our new Molecular Cell paper on missense mutations in Polycomb genes and how they can disrupt chromatin regulation to drive neurodevelopmental disorders. A huge thank you to everyone involved, and to our amazing collaborators!
www.cell.com/molecular-ce...

@lluismorey.bsky.social we are looking forward to your presentation at our #FusionEpigenetics meeting in Portugal this October!
Please share this with your followers to let them know you will speaking, and to register & submit today to join us
🔗 bit.ly/4rC6B45

Exciting news! The lab is moving to Colorado at @cuanschutz.bsky.social 🎉
We’ll be recruiting at all levels—stay tuned!

DOT1L provides transcriptional memory through PRC1.1 antagonism - Nature Cell Biology Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibit...

H3K79me2/3 is sufficient to antagonise PRC1 www.nature.com/articles/s41...

Come join us for a great week of science in Dublin this summer! @brianstrahl.bsky.social @vanrechemlab.bsky.social @bonalditiziana.bsky.social @garcialabms.bsky.social @metorrespadilla.bsky.social

Our #FusionEpigenetics speaker line-up is 🔥
Join us in Portugal in October 2026 to hear directly from the scientists shaping the field.
See who’s speaking and save your spot here!
➡️ bit.ly/4sq1khf

Our recent paper with @batllelab.bsky.social is now available in Cancer Discovery formatted PDF here aacrjournals.org/cancerdiscov...

Enjoy Xmas reading 😅🎄🍾

This story is absolutely wild. Did you know that avocados change sex over the course of a day? And that it's controlled by a single ancient balanced polymorphism? This is flat our crazy

H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations Histone modifications play crucial roles in genome function. However, how chromatin integrates physiological and metabolic responses at the molecular …

Excited to share new manuscript on histone acylations, exploring how H4K16 acylations regulate inter and intranucleosomal interactions and how they confer resilience to metabolic challenges in vivo. Thanks to all authors +1 author @sandrani.bsky.social Enjoy 👇👇
www.sciencedirect.com/science/arti...

Systematic maps reveal how human chromosomes are organized Our genomes are highly structured, which facilitates gene regulation. An ambitious project has catalogued the organization of DNA in the nuclei of human cells.

It was a pleasure to write this News & Views article for the 4D Nucleome flagship article: www.nature.com/articles/d41...

With great editorial support from @hollyasmith.bsky.social!

Read the 4D Nucleome paper here: www.nature.com/articles/s41...

An integrated view of the structure and function of the human 4D nucleome - Nature The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...

A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists!

www.nature.com/articles/s41...

A few days left to apply for exciting PhD and Postdoc opportunities in wonderful Copenhagen and join our efforts in understanding Epigenetic Cell Memory.

Reevaluation of whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila | PNAS Recent work suggests that asymmetric segregation of preexisting and newly synthesized canonical histone 3.1 (H3.1), but not variant histone 3.3A (H...

Reevaluation of whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila | PNAS www.pnas.org/doi/10.1073/...

Dynamic evolution of EZHIP, an inhibitor of the Polycomb Repressive Complex 2 in mammals The Polycomb Repressive Complex 2 (PRC2) is an ancient, conserved chromatin-interacting complex that controls gene expression, facilitating differentiation and cellular identity during development. It...

@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/

Congratulations! Outstanding as always!

SET1/MLL complexes control transcription independently of H3K4me3 Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...

An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!

www.biorxiv.org/content/10.6...

Excited to see the latest from the Klose lab out this morning! Our brilliant PhD student Alan, now Dr Au, has dissected how SET1/MLL complexes shape H3K4me3 and shows they regulate transcription independently of their cat activity. He teamed up with Aleks to explore how. A few surprises!

Can't believe it's that time of year - registration already open for next year's Transcription & Chromatin meeting. Almost half the talks are selected from the abstracts, so register soon before it fills up. This is a very lively meeting, with plenty of time to discuss over dinner & at the bar

Yesterday’s lab lunch felt really special. We took a moment to celebrate new papers, promotions, fresh faces in the lab—and, most of all, friendship. Grateful for this team. We’re stronger than ever.

We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas.
www.biorxiv.org/content/10.1...

Bernie Sanders' office has put out a report this morning on Trump's NIH cuts: "Trump officials effectively cut $2.7 billion in [NIH] funding in the first three months of 2025 – including a 31 percent cut to cancer research through March, compared to the same timeframe last year."

Congratulations Elena!

Northwestern University to self-fund research despite Trump administration freeze While university officials said they’ve still not received official word of such action, they acknowledged receiving about 100 stop-work orders from the federal government on roughly 100 fede…

Northwestern just announced that the university will meet the funding needs of any research that is being impacted by stop orders. LET'S GOOOOOOOOOOOOO! #edusky #academicsky

wgntv.com/evanston/nor...

Seven New Cancer Grand Challenges Announced

www.cancergrandchallenges.org/new-challenges

With awards of up to £20m ($25m). Expressions of Interest are now open.

@cancergrand.bsky.social #CancerGrandChallenges

Very happy to see this outstanding work finally out!

Thank you to all the people who helped with making this work possible, inc. MSKCC Center for Epigenetic Research PJ Hamatd & Richard Koche @lluismorey.bsky.social . You all put a piece in this puzzle.

Thank you to our editor &reviewers for being scientific allies,making our work better 🙏🏻